Application and Molecular Mechanisms of Extracellular Vesicles Derived from Mesenchymal Stem Cells in Osteoporosis
Osteoporosis (OP) is a chronic bone disease characterized by decreased bone mass, destroyed bone microstructure, and increased bone fragility. Accumulative evidence shows that extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) (MSC-EVs), especially exosomes (Exos), exhibit great...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/44/12/433 |
| _version_ | 1827641267590266880 |
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| author | Yajing Yang Lei Yuan Hong Cao Jianmin Guo Xuchang Zhou Zhipeng Zeng |
| author_facet | Yajing Yang Lei Yuan Hong Cao Jianmin Guo Xuchang Zhou Zhipeng Zeng |
| author_sort | Yajing Yang |
| collection | DOAJ |
| description | Osteoporosis (OP) is a chronic bone disease characterized by decreased bone mass, destroyed bone microstructure, and increased bone fragility. Accumulative evidence shows that extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) (MSC-EVs), especially exosomes (Exos), exhibit great potential in the treatment of OP. However, the research on MSC-EVs in the treatment of OP is still in the initial stage. The potential mechanism has not been fully clarified. Therefore, by reviewing the relevant literature of MSC-EVs and OP in recent years, we summarized the latest application of bone targeted MSC-EVs in the treatment of OP and further elaborated the potential mechanism of MSC-EVs in regulating bone formation, bone resorption, bone angiogenesis, and immune regulation through internal bioactive molecules to alleviate OP, providing a theoretical basis for the related research of MSC-EVs in the treatment of OP. |
| first_indexed | 2024-03-09T17:11:21Z |
| format | Article |
| id | doaj.art-56ee3d2e7d224c2196039cd9e79c1407 |
| institution | Directory Open Access Journal |
| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-09T17:11:21Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj.art-56ee3d2e7d224c2196039cd9e79c14072023-11-24T14:03:58ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452022-12-0144126346636710.3390/cimb44120433Application and Molecular Mechanisms of Extracellular Vesicles Derived from Mesenchymal Stem Cells in OsteoporosisYajing Yang0Lei Yuan1Hong Cao2Jianmin Guo3Xuchang Zhou4Zhipeng Zeng5School of Sport Medicine and Rehabilitation, Beijing Sport University, Beijing 100084, ChinaSchool of Sport Medicine and Rehabilitation, Beijing Sport University, Beijing 100084, ChinaSchool of Kinesiology, Shanghai University of Sport, Shanghai 200438, ChinaSchool of Kinesiology, Shanghai University of Sport, Shanghai 200438, ChinaSchool of Sport Medicine and Rehabilitation, Beijing Sport University, Beijing 100084, ChinaSchool of Sport Medicine and Rehabilitation, Beijing Sport University, Beijing 100084, ChinaOsteoporosis (OP) is a chronic bone disease characterized by decreased bone mass, destroyed bone microstructure, and increased bone fragility. Accumulative evidence shows that extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) (MSC-EVs), especially exosomes (Exos), exhibit great potential in the treatment of OP. However, the research on MSC-EVs in the treatment of OP is still in the initial stage. The potential mechanism has not been fully clarified. Therefore, by reviewing the relevant literature of MSC-EVs and OP in recent years, we summarized the latest application of bone targeted MSC-EVs in the treatment of OP and further elaborated the potential mechanism of MSC-EVs in regulating bone formation, bone resorption, bone angiogenesis, and immune regulation through internal bioactive molecules to alleviate OP, providing a theoretical basis for the related research of MSC-EVs in the treatment of OP.https://www.mdpi.com/1467-3045/44/12/433osteoporosisextracellular vesiclesexosomesmiRNAsmesenchymal stem cells |
| spellingShingle | Yajing Yang Lei Yuan Hong Cao Jianmin Guo Xuchang Zhou Zhipeng Zeng Application and Molecular Mechanisms of Extracellular Vesicles Derived from Mesenchymal Stem Cells in Osteoporosis Current Issues in Molecular Biology osteoporosis extracellular vesicles exosomes miRNAs mesenchymal stem cells |
| title | Application and Molecular Mechanisms of Extracellular Vesicles Derived from Mesenchymal Stem Cells in Osteoporosis |
| title_full | Application and Molecular Mechanisms of Extracellular Vesicles Derived from Mesenchymal Stem Cells in Osteoporosis |
| title_fullStr | Application and Molecular Mechanisms of Extracellular Vesicles Derived from Mesenchymal Stem Cells in Osteoporosis |
| title_full_unstemmed | Application and Molecular Mechanisms of Extracellular Vesicles Derived from Mesenchymal Stem Cells in Osteoporosis |
| title_short | Application and Molecular Mechanisms of Extracellular Vesicles Derived from Mesenchymal Stem Cells in Osteoporosis |
| title_sort | application and molecular mechanisms of extracellular vesicles derived from mesenchymal stem cells in osteoporosis |
| topic | osteoporosis extracellular vesicles exosomes miRNAs mesenchymal stem cells |
| url | https://www.mdpi.com/1467-3045/44/12/433 |
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