The functional characterization of phosphorylation of tristetraprolin at C-terminal NOT1-binding domain

The functional characterization of phosphorylation of tristetraprolin at C-terminal NOT1-binding domain

Abstract Background Tristetraprolin (TTP) family proteins contain conserved tandem CCCH zinc-finger binding to AU-rich elements and C-terminal NOT1-binding domain. TTP is phosphorylated extensively in cells, and its mRNA destabilization activity is regulated by protein phosphorylation. Methods We ge...

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Bibliographic Details
Main Authors: Hsin-Hui Hsieh, Yen-An Chen, Yao-Jen Chang, Hsin-Hui Wang, Ya-Han Yu, Sheng-Wei Lin, Yin-Jung Huang, Steven Lin, Ching-Jin Chang
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Journal of Inflammation
Subjects:
Tristetraprolin
Phosphorylation
CNOT1, deadenylase
Online Access:https://doi.org/10.1186/s12950-021-00288-2

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