The predicting roles of carcinoembryonic antigen and its underlying mechanism in the progression of coronavirus disease 2019
Abstract Background The coronavirus disease 2019 (COVID-19) has induced a worldwide epidemiological event with a high infectivity and mortality. However, the predicting biomarkers and their potential mechanism in the progression of COVID-19 are not well known. Objective The aim of this study is to i...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-07-01
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| Series: | Critical Care |
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| Online Access: | https://doi.org/10.1186/s13054-021-03661-y |
| _version_ | 1818618503514554368 |
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| author | Runzhi Huang Tong Meng Qiongfang Zha Kebin Cheng Xin Zhou Junhua Zheng Dingyu Zhang Ruilin Liu |
| author_facet | Runzhi Huang Tong Meng Qiongfang Zha Kebin Cheng Xin Zhou Junhua Zheng Dingyu Zhang Ruilin Liu |
| author_sort | Runzhi Huang |
| collection | DOAJ |
| description | Abstract Background The coronavirus disease 2019 (COVID-19) has induced a worldwide epidemiological event with a high infectivity and mortality. However, the predicting biomarkers and their potential mechanism in the progression of COVID-19 are not well known. Objective The aim of this study is to identify the candidate predictors of COVID-19 and investigate their underlying mechanism. Methods The retrospective study was conducted to identify the potential laboratory indicators with prognostic values of COVID-19 disease. Then, the prognostic nomogram was constructed to predict the overall survival of COVID-19 patients. Additionally, the scRNA-seq data of BALF and PBMCs from COVID-19 patients were downloaded to investigate the underlying mechanism of the most important prognostic indicators in lungs and peripherals, respectively. Results In total, 304 hospitalized adult COVID-19 patients in Wuhan Jinyintan Hospital were included in the retrospective study. CEA was the only laboratory indicator with significant difference in the univariate (P < 0.001) and multivariate analysis (P = 0.020). The scRNA-seq data of BALF and PBMCs from COVID-19 patients were downloaded to investigate the underlying mechanism of CEA in lungs and peripherals, respectively. The results revealed the potential roles of CEA were significantly distributed in type II pneumocytes of BALF and developing neutrophils of PBMCs, participating in the progression of COVID-19 by regulating the cell–cell communication. Conclusion This study identifies the prognostic roles of CEA in COVID-19 patients and implies the potential roles of CEACAM8-CEACAM6 in the progression of COVID-19 by regulating the cell–cell communication of developing neutrophils and type II pneumocyte. |
| first_indexed | 2024-12-16T17:22:38Z |
| format | Article |
| id | doaj.art-56ef72e06e3940ea9133cc8fc5dd4699 |
| institution | Directory Open Access Journal |
| issn | 1364-8535 |
| language | English |
| last_indexed | 2024-12-16T17:22:38Z |
| publishDate | 2021-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Critical Care |
| spelling | doaj.art-56ef72e06e3940ea9133cc8fc5dd46992022-12-21T22:23:08ZengBMCCritical Care1364-85352021-07-0125112010.1186/s13054-021-03661-yThe predicting roles of carcinoembryonic antigen and its underlying mechanism in the progression of coronavirus disease 2019Runzhi Huang0Tong Meng1Qiongfang Zha2Kebin Cheng3Xin Zhou4Junhua Zheng5Dingyu Zhang6Ruilin Liu7Department of Respiratory and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji UniversityShanghai General Hospital, 100 Haining RoadDepartment of Respiratory and Critical Care Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, Tongji University School of MedicineDepartment of Respiratory and Critical Care Medicine, Shanghai General HospitalTongji University Cancer Center, Shanghai Tenth People’s Hospital, Tongji University School of MedicineWuhan Jinyintan HospitalDepartment of Respiratory and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji UniversityAbstract Background The coronavirus disease 2019 (COVID-19) has induced a worldwide epidemiological event with a high infectivity and mortality. However, the predicting biomarkers and their potential mechanism in the progression of COVID-19 are not well known. Objective The aim of this study is to identify the candidate predictors of COVID-19 and investigate their underlying mechanism. Methods The retrospective study was conducted to identify the potential laboratory indicators with prognostic values of COVID-19 disease. Then, the prognostic nomogram was constructed to predict the overall survival of COVID-19 patients. Additionally, the scRNA-seq data of BALF and PBMCs from COVID-19 patients were downloaded to investigate the underlying mechanism of the most important prognostic indicators in lungs and peripherals, respectively. Results In total, 304 hospitalized adult COVID-19 patients in Wuhan Jinyintan Hospital were included in the retrospective study. CEA was the only laboratory indicator with significant difference in the univariate (P < 0.001) and multivariate analysis (P = 0.020). The scRNA-seq data of BALF and PBMCs from COVID-19 patients were downloaded to investigate the underlying mechanism of CEA in lungs and peripherals, respectively. The results revealed the potential roles of CEA were significantly distributed in type II pneumocytes of BALF and developing neutrophils of PBMCs, participating in the progression of COVID-19 by regulating the cell–cell communication. Conclusion This study identifies the prognostic roles of CEA in COVID-19 patients and implies the potential roles of CEACAM8-CEACAM6 in the progression of COVID-19 by regulating the cell–cell communication of developing neutrophils and type II pneumocyte.https://doi.org/10.1186/s13054-021-03661-yCoronavirus disease 2019Carcinoembryonic antigenCarcinoembryonic antigen-related cell adhesion moleculesDeveloping neutrophilsType II pneumocyte |
| spellingShingle | Runzhi Huang Tong Meng Qiongfang Zha Kebin Cheng Xin Zhou Junhua Zheng Dingyu Zhang Ruilin Liu The predicting roles of carcinoembryonic antigen and its underlying mechanism in the progression of coronavirus disease 2019 Critical Care Coronavirus disease 2019 Carcinoembryonic antigen Carcinoembryonic antigen-related cell adhesion molecules Developing neutrophils Type II pneumocyte |
| title | The predicting roles of carcinoembryonic antigen and its underlying mechanism in the progression of coronavirus disease 2019 |
| title_full | The predicting roles of carcinoembryonic antigen and its underlying mechanism in the progression of coronavirus disease 2019 |
| title_fullStr | The predicting roles of carcinoembryonic antigen and its underlying mechanism in the progression of coronavirus disease 2019 |
| title_full_unstemmed | The predicting roles of carcinoembryonic antigen and its underlying mechanism in the progression of coronavirus disease 2019 |
| title_short | The predicting roles of carcinoembryonic antigen and its underlying mechanism in the progression of coronavirus disease 2019 |
| title_sort | predicting roles of carcinoembryonic antigen and its underlying mechanism in the progression of coronavirus disease 2019 |
| topic | Coronavirus disease 2019 Carcinoembryonic antigen Carcinoembryonic antigen-related cell adhesion molecules Developing neutrophils Type II pneumocyte |
| url | https://doi.org/10.1186/s13054-021-03661-y |
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