Y RNA: An Overview of Their Role as Potential Biomarkers and Molecular Targets in Human Cancers
Y RNA are a class of small non-coding RNA that are largely conserved. Although their discovery was almost 40 years ago, their function is still under investigation. This is evident in cancer biology, where their role was first studied just a dozen years ago. Since then, only a few contributions were...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-05-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/5/1238 |
| _version_ | 1797567957020180480 |
|---|---|
| author | Caterina Gulìa Fabrizio Signore Marco Gaffi Silvia Gigli Raffaella Votino Roberto Nucciotti Luca Bertacca Simona Zaami Alberto Baffa Edoardo Santini Alessandro Porrello Roberto Piergentili |
| author_facet | Caterina Gulìa Fabrizio Signore Marco Gaffi Silvia Gigli Raffaella Votino Roberto Nucciotti Luca Bertacca Simona Zaami Alberto Baffa Edoardo Santini Alessandro Porrello Roberto Piergentili |
| author_sort | Caterina Gulìa |
| collection | DOAJ |
| description | Y RNA are a class of small non-coding RNA that are largely conserved. Although their discovery was almost 40 years ago, their function is still under investigation. This is evident in cancer biology, where their role was first studied just a dozen years ago. Since then, only a few contributions were published, mostly scattered across different tumor types and, in some cases, also suffering from methodological limitations. Nonetheless, these sparse data may be used to make some estimations and suggest routes to better understand the role of Y RNA in cancer formation and characterization. Here we summarize the current knowledge about Y RNA in multiple types of cancer, also including a paragraph about tumors that might be included in this list in the future, if more evidence becomes available. The picture arising indicates that Y RNA might be useful in tumor characterization, also relying on non-invasive methods, such as the analysis of the content of extracellular vesicles (EV) that are retrieved from blood plasma and other bodily fluids. Due to the established role of Y RNA in DNA replication, it is possible to hypothesize their therapeutic targeting to inhibit cell proliferation in oncological patients. |
| first_indexed | 2024-03-10T19:49:33Z |
| format | Article |
| id | doaj.art-56ef79720acc4b1693cd7f9f6eeb7ebf |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T19:49:33Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-56ef79720acc4b1693cd7f9f6eeb7ebf2023-11-20T00:30:39ZengMDPI AGCancers2072-66942020-05-01125123810.3390/cancers12051238Y RNA: An Overview of Their Role as Potential Biomarkers and Molecular Targets in Human CancersCaterina Gulìa0Fabrizio Signore1Marco Gaffi2Silvia Gigli3Raffaella Votino4Roberto Nucciotti5Luca Bertacca6Simona Zaami7Alberto Baffa8Edoardo Santini9Alessandro Porrello10Roberto Piergentili11Department of Urology, Misericordia Hospital, 58100 Grosseto, ItalyDepartment of Obstetrics and Gynecology, Misericordia Hospital, 58100 Grosseto, ItalyPediatric Surgery and Urology Unit, Azienda Ospedaliera San Camillo-Forlanini, 00152 Rome, ItalyDepartment of Diagnostic Imaging, Sandro Pertini Hospital, 00157 Rome, ItalyDepartment of Obstetrics and Gynecology, Misericordia Hospital, 58100 Grosseto, ItalyDepartment of Urology, Misericordia Hospital, 58100 Grosseto, ItalyPediatric Emergency Unit, Misericordia Hospital, 58100 Grosseto, ItalyUnit of Forensic Toxicology (UoFT), Department of Anatomical, Histological, Forensic and Orthopedic Sciences, Sapienza University of Rome, Viale Regina Elena 336, 00185 Rome, ItalyDepartment of Obstetrics and Gynecology, Misericordia Hospital, 58100 Grosseto, ItalyDepartment of Urology, Misericordia Hospital, 58100 Grosseto, ItalyLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USAItalian National Research Council—Institute of Molecular Biology and Pathology, 00185 Rome, ItalyY RNA are a class of small non-coding RNA that are largely conserved. Although their discovery was almost 40 years ago, their function is still under investigation. This is evident in cancer biology, where their role was first studied just a dozen years ago. Since then, only a few contributions were published, mostly scattered across different tumor types and, in some cases, also suffering from methodological limitations. Nonetheless, these sparse data may be used to make some estimations and suggest routes to better understand the role of Y RNA in cancer formation and characterization. Here we summarize the current knowledge about Y RNA in multiple types of cancer, also including a paragraph about tumors that might be included in this list in the future, if more evidence becomes available. The picture arising indicates that Y RNA might be useful in tumor characterization, also relying on non-invasive methods, such as the analysis of the content of extracellular vesicles (EV) that are retrieved from blood plasma and other bodily fluids. Due to the established role of Y RNA in DNA replication, it is possible to hypothesize their therapeutic targeting to inhibit cell proliferation in oncological patients.https://www.mdpi.com/2072-6694/12/5/1238RNY1RNY3RNY4RNY5RO60DNA replication |
| spellingShingle | Caterina Gulìa Fabrizio Signore Marco Gaffi Silvia Gigli Raffaella Votino Roberto Nucciotti Luca Bertacca Simona Zaami Alberto Baffa Edoardo Santini Alessandro Porrello Roberto Piergentili Y RNA: An Overview of Their Role as Potential Biomarkers and Molecular Targets in Human Cancers Cancers RNY1 RNY3 RNY4 RNY5 RO60 DNA replication |
| title | Y RNA: An Overview of Their Role as Potential Biomarkers and Molecular Targets in Human Cancers |
| title_full | Y RNA: An Overview of Their Role as Potential Biomarkers and Molecular Targets in Human Cancers |
| title_fullStr | Y RNA: An Overview of Their Role as Potential Biomarkers and Molecular Targets in Human Cancers |
| title_full_unstemmed | Y RNA: An Overview of Their Role as Potential Biomarkers and Molecular Targets in Human Cancers |
| title_short | Y RNA: An Overview of Their Role as Potential Biomarkers and Molecular Targets in Human Cancers |
| title_sort | y rna an overview of their role as potential biomarkers and molecular targets in human cancers |
| topic | RNY1 RNY3 RNY4 RNY5 RO60 DNA replication |
| url | https://www.mdpi.com/2072-6694/12/5/1238 |
| work_keys_str_mv | AT caterinagulia yrnaanoverviewoftheirroleaspotentialbiomarkersandmoleculartargetsinhumancancers AT fabriziosignore yrnaanoverviewoftheirroleaspotentialbiomarkersandmoleculartargetsinhumancancers AT marcogaffi yrnaanoverviewoftheirroleaspotentialbiomarkersandmoleculartargetsinhumancancers AT silviagigli yrnaanoverviewoftheirroleaspotentialbiomarkersandmoleculartargetsinhumancancers AT raffaellavotino yrnaanoverviewoftheirroleaspotentialbiomarkersandmoleculartargetsinhumancancers AT robertonucciotti yrnaanoverviewoftheirroleaspotentialbiomarkersandmoleculartargetsinhumancancers AT lucabertacca yrnaanoverviewoftheirroleaspotentialbiomarkersandmoleculartargetsinhumancancers AT simonazaami yrnaanoverviewoftheirroleaspotentialbiomarkersandmoleculartargetsinhumancancers AT albertobaffa yrnaanoverviewoftheirroleaspotentialbiomarkersandmoleculartargetsinhumancancers AT edoardosantini yrnaanoverviewoftheirroleaspotentialbiomarkersandmoleculartargetsinhumancancers AT alessandroporrello yrnaanoverviewoftheirroleaspotentialbiomarkersandmoleculartargetsinhumancancers AT robertopiergentili yrnaanoverviewoftheirroleaspotentialbiomarkersandmoleculartargetsinhumancancers |