Mycobacterium tuberculosis impairs human memory CD4+ T cell recognition of M2 but not M1-like macrophages

Mycobacterium tuberculosis impairs human memory CD4+ T cell recognition of M2 but not M1-like macrophages

Summary: Direct recognition of Mycobacterium tuberculosis (Mtb)-infected cells is required for protection by CD4+ T cells. While impaired T cell recognition of Mtb-infected macrophages was demonstrated in mice, data are lacking for humans. Using T cells and monocyte-derived macrophages (MDMs) from i...

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Bibliographic Details
Main Authors: Daniel P. Gail, Vinicius G. Suzart, Weinan Du, Avinaash Kaur Sandhu, Jessica Jarvela, Mary Nantongo, Ivan Mwebaza, Soumya Panigrahi, Michael L. Freeman, David H. Canaday, W. Henry Boom, Richard F. Silver, Stephen M. Carpenter
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:iScience
Subjects:
Immunology
Immune response
Microbiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223017832

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