Pharmacogenomic Biomarkers of Follicle-Stimulating Hormone Receptor Malfunction in Females with Impaired Ovarian Response—A Genetic Survey
Follicle-stimulating hormone receptor (FSHR) plays an essential role as one of the most important molecules in response to some of infertility related medications. Impaired ovarian reserve and poor response to such treatments are partially dependent on the FSHR molecule itself. However, the function...
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MDPI AG
2021-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/2/170 |
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| author | Alireza Tafazoli Sławomir Wołczyński Natalia Wawrusiewicz-Kurylonek Seyed-Alireza Esmaeili Wojciech Miltyk |
| author_facet | Alireza Tafazoli Sławomir Wołczyński Natalia Wawrusiewicz-Kurylonek Seyed-Alireza Esmaeili Wojciech Miltyk |
| author_sort | Alireza Tafazoli |
| collection | DOAJ |
| description | Follicle-stimulating hormone receptor (FSHR) plays an essential role as one of the most important molecules in response to some of infertility related medications. Impaired ovarian reserve and poor response to such treatments are partially dependent on the FSHR molecule itself. However, the function and drug sensitivity for this receptor may change due to various allele and polymorphisms in the <i>FSHR</i> gene. Studies indicated some of the FSHR-mediated treatments utilized in clinical centers display different outcomes in specific populations, which may arise from FSHR altered genotypes in certain patients. To support the increased demands for reaching the personalized drug and hormone therapy in clinics, focusing on actionable variants through Pharmacogenomic analysis of this receptor may be necessary. The current study tries to display a perspective view on genetic assessments for Pharmacogenomic profiling of the <i>FSHR</i> gene via providing a systematic and critical overview on the genetics of FSHR and its diverse responses to ligands for infertility treatment in females with impaired ovarian responses and show the potential effects of the patient genetic make-up on related binding substances efficacy. All identified functional drug-related alleles were selected through a comprehensive literature search and analyzed. Advanced technologies for the genetic evaluation of them are also discussed properly. |
| first_indexed | 2024-03-10T13:27:00Z |
| format | Article |
| id | doaj.art-56f21bb763bf4c73b4eec368020bd172 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T13:27:00Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-56f21bb763bf4c73b4eec368020bd1722023-11-21T08:48:12ZengMDPI AGJournal of Clinical Medicine2077-03832021-01-0110217010.3390/jcm10020170Pharmacogenomic Biomarkers of Follicle-Stimulating Hormone Receptor Malfunction in Females with Impaired Ovarian Response—A Genetic SurveyAlireza Tafazoli0Sławomir Wołczyński1Natalia Wawrusiewicz-Kurylonek2Seyed-Alireza Esmaeili3Wojciech Miltyk4Department of Analysis and Bioanalysis of Medicines, Faculty of Pharmacy with the Division of Laboratory Medicine, Medical University of Białystok, 15-089 Białystok, PolandDepartment of Reproduction and Gynecological Endocrinology, Medical University of Białystok, 15-222 Białystok, PolandDepartment of Clinical Genetics, Medical University of Białystok, 15-089 Białystok, PolandImmunology Department, Faculty of Medicine, Mashhad University of Medical Sciences, 9177948564 Mashhad, IranDepartment of Analysis and Bioanalysis of Medicines, Faculty of Pharmacy with the Division of Laboratory Medicine, Medical University of Białystok, 15-089 Białystok, PolandFollicle-stimulating hormone receptor (FSHR) plays an essential role as one of the most important molecules in response to some of infertility related medications. Impaired ovarian reserve and poor response to such treatments are partially dependent on the FSHR molecule itself. However, the function and drug sensitivity for this receptor may change due to various allele and polymorphisms in the <i>FSHR</i> gene. Studies indicated some of the FSHR-mediated treatments utilized in clinical centers display different outcomes in specific populations, which may arise from FSHR altered genotypes in certain patients. To support the increased demands for reaching the personalized drug and hormone therapy in clinics, focusing on actionable variants through Pharmacogenomic analysis of this receptor may be necessary. The current study tries to display a perspective view on genetic assessments for Pharmacogenomic profiling of the <i>FSHR</i> gene via providing a systematic and critical overview on the genetics of FSHR and its diverse responses to ligands for infertility treatment in females with impaired ovarian responses and show the potential effects of the patient genetic make-up on related binding substances efficacy. All identified functional drug-related alleles were selected through a comprehensive literature search and analyzed. Advanced technologies for the genetic evaluation of them are also discussed properly.https://www.mdpi.com/2077-0383/10/2/170FSHRpharmacogenomicspersonalized drug therapy |
| spellingShingle | Alireza Tafazoli Sławomir Wołczyński Natalia Wawrusiewicz-Kurylonek Seyed-Alireza Esmaeili Wojciech Miltyk Pharmacogenomic Biomarkers of Follicle-Stimulating Hormone Receptor Malfunction in Females with Impaired Ovarian Response—A Genetic Survey Journal of Clinical Medicine FSHR pharmacogenomics personalized drug therapy |
| title | Pharmacogenomic Biomarkers of Follicle-Stimulating Hormone Receptor Malfunction in Females with Impaired Ovarian Response—A Genetic Survey |
| title_full | Pharmacogenomic Biomarkers of Follicle-Stimulating Hormone Receptor Malfunction in Females with Impaired Ovarian Response—A Genetic Survey |
| title_fullStr | Pharmacogenomic Biomarkers of Follicle-Stimulating Hormone Receptor Malfunction in Females with Impaired Ovarian Response—A Genetic Survey |
| title_full_unstemmed | Pharmacogenomic Biomarkers of Follicle-Stimulating Hormone Receptor Malfunction in Females with Impaired Ovarian Response—A Genetic Survey |
| title_short | Pharmacogenomic Biomarkers of Follicle-Stimulating Hormone Receptor Malfunction in Females with Impaired Ovarian Response—A Genetic Survey |
| title_sort | pharmacogenomic biomarkers of follicle stimulating hormone receptor malfunction in females with impaired ovarian response a genetic survey |
| topic | FSHR pharmacogenomics personalized drug therapy |
| url | https://www.mdpi.com/2077-0383/10/2/170 |
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