Comparing symptom measurement tools in pediatric narcolepsy
Narcolepsy is a rare disabling neurological disease, affecting children and adults. The most recent development of measurement tools for narcolepsy were developed for adults; only a few tools are available for children without comparison on their validity. This research aims at comparing the validit...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Sleep Epidemiology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667343622000130 |
| _version_ | 1811187260082618368 |
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| author | Philippe Lehert Giuseppe Plazzi |
| author_facet | Philippe Lehert Giuseppe Plazzi |
| author_sort | Philippe Lehert |
| collection | DOAJ |
| description | Narcolepsy is a rare disabling neurological disease, affecting children and adults. The most recent development of measurement tools for narcolepsy were developed for adults; only a few tools are available for children without comparison on their validity. This research aims at comparing the validity of existing measurement tools in paediatric narcolepsy. From an ongoing randomized controlled trial, we extracted the data blind to the treatment of the 93 first terminating patients on which we compared the Paediatric Daytime Sleepiness Scale (PDSS), the Ullanlina Narcolepsy scale (UNS), the Child and Adolescent Sleepiness Questionnaire (CASS), the maintenance of wakefulness test (MWT), and the cataplexy episodes count (CEC).The comparison was carried out on reliability, internal consistency, sensitivity to change, minimum important difference, construct validity and concurrent validity.We provide evidence that the Ullanlina UNS score, currently used for screening purposes, constitutes a reliable and sensitive overall symptom measurement tool. Its subscore (UNS-CTP) based on the first four items permits a sensitive measurement of cataplexy, whereas the UNS-EDS subscore was found inferior to the PDSS scale. Compared with the objective measurement of symptoms (MWT, CEC), these scales better correlated with the clinical global impression of change in time, they are characterized by higher sensitivity, and they are much easier to use. |
| first_indexed | 2024-04-11T14:00:22Z |
| format | Article |
| id | doaj.art-56f3b2f7c2774e9692d8d3e50967508a |
| institution | Directory Open Access Journal |
| issn | 2667-3436 |
| language | English |
| last_indexed | 2024-04-11T14:00:22Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Sleep Epidemiology |
| spelling | doaj.art-56f3b2f7c2774e9692d8d3e50967508a2022-12-22T04:20:09ZengElsevierSleep Epidemiology2667-34362022-12-012100032Comparing symptom measurement tools in pediatric narcolepsyPhilippe Lehert0Giuseppe Plazzi1Faculty of Economics, University Louvain, Belgium; Faculty of Medicine, University of Melbourne, Australia; Corresponding author.IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, ItalyNarcolepsy is a rare disabling neurological disease, affecting children and adults. The most recent development of measurement tools for narcolepsy were developed for adults; only a few tools are available for children without comparison on their validity. This research aims at comparing the validity of existing measurement tools in paediatric narcolepsy. From an ongoing randomized controlled trial, we extracted the data blind to the treatment of the 93 first terminating patients on which we compared the Paediatric Daytime Sleepiness Scale (PDSS), the Ullanlina Narcolepsy scale (UNS), the Child and Adolescent Sleepiness Questionnaire (CASS), the maintenance of wakefulness test (MWT), and the cataplexy episodes count (CEC).The comparison was carried out on reliability, internal consistency, sensitivity to change, minimum important difference, construct validity and concurrent validity.We provide evidence that the Ullanlina UNS score, currently used for screening purposes, constitutes a reliable and sensitive overall symptom measurement tool. Its subscore (UNS-CTP) based on the first four items permits a sensitive measurement of cataplexy, whereas the UNS-EDS subscore was found inferior to the PDSS scale. Compared with the objective measurement of symptoms (MWT, CEC), these scales better correlated with the clinical global impression of change in time, they are characterized by higher sensitivity, and they are much easier to use.http://www.sciencedirect.com/science/article/pii/S2667343622000130PediatryNarcolepsyValidationMeasurement |
| spellingShingle | Philippe Lehert Giuseppe Plazzi Comparing symptom measurement tools in pediatric narcolepsy Sleep Epidemiology Pediatry Narcolepsy Validation Measurement |
| title | Comparing symptom measurement tools in pediatric narcolepsy |
| title_full | Comparing symptom measurement tools in pediatric narcolepsy |
| title_fullStr | Comparing symptom measurement tools in pediatric narcolepsy |
| title_full_unstemmed | Comparing symptom measurement tools in pediatric narcolepsy |
| title_short | Comparing symptom measurement tools in pediatric narcolepsy |
| title_sort | comparing symptom measurement tools in pediatric narcolepsy |
| topic | Pediatry Narcolepsy Validation Measurement |
| url | http://www.sciencedirect.com/science/article/pii/S2667343622000130 |
| work_keys_str_mv | AT philippelehert comparingsymptommeasurementtoolsinpediatricnarcolepsy AT giuseppeplazzi comparingsymptommeasurementtoolsinpediatricnarcolepsy |