TLR7 and IL-6 differentially regulate the effects of rotarod exercise on the transcriptomic profile and neurogenesis to influence anxiety and memory
Summary: Voluntary exercise is well known to benefit brain performance. In contrast, forced exercise induces inflammation-related stress responses and may cause psychiatric disorders. Here, we unexpectedly found that rotarod testing, a frequently applied assay for evaluating rodent motor coordinatio...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-04-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004221003527 |
| _version_ | 1818596056879857664 |
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| author | Yun-Fen Hung Yi-Ping Hsueh |
| author_facet | Yun-Fen Hung Yi-Ping Hsueh |
| author_sort | Yun-Fen Hung |
| collection | DOAJ |
| description | Summary: Voluntary exercise is well known to benefit brain performance. In contrast, forced exercise induces inflammation-related stress responses and may cause psychiatric disorders. Here, we unexpectedly found that rotarod testing, a frequently applied assay for evaluating rodent motor coordination, induces anxiety and alters spatial learning/memory performance of mice. Rotarod testing upregulated genes involved in the unfolded protein response and stress responses and downregulated genes associated with neurogenesis and neuronal differentiation. It impacts two downstream pathways. The first is the IL-6-dependent pathway, which mediates rotarod-induced anxiety. The second is the Toll-like receptor 7 (TLR7)-dependent pathway, which is involved in the effect of rotarod exercise on gene expression and its impact on contextual learning and memory of mice. Thus, although rotarod exercise does not induce systemic inflammation, it influences innate immunity-related responses in the brain, controls gene expression and, consequently, regulates anxiety and contextual learning and memory. |
| first_indexed | 2024-12-16T11:25:51Z |
| format | Article |
| id | doaj.art-56f3cc43cb004bbda4bc4c4c2b51ca64 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-16T11:25:51Z |
| publishDate | 2021-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-56f3cc43cb004bbda4bc4c4c2b51ca642022-12-21T22:33:21ZengElsevieriScience2589-00422021-04-01244102384TLR7 and IL-6 differentially regulate the effects of rotarod exercise on the transcriptomic profile and neurogenesis to influence anxiety and memoryYun-Fen Hung0Yi-Ping Hsueh1Institute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan, ROCInstitute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan, ROC; Corresponding authorSummary: Voluntary exercise is well known to benefit brain performance. In contrast, forced exercise induces inflammation-related stress responses and may cause psychiatric disorders. Here, we unexpectedly found that rotarod testing, a frequently applied assay for evaluating rodent motor coordination, induces anxiety and alters spatial learning/memory performance of mice. Rotarod testing upregulated genes involved in the unfolded protein response and stress responses and downregulated genes associated with neurogenesis and neuronal differentiation. It impacts two downstream pathways. The first is the IL-6-dependent pathway, which mediates rotarod-induced anxiety. The second is the Toll-like receptor 7 (TLR7)-dependent pathway, which is involved in the effect of rotarod exercise on gene expression and its impact on contextual learning and memory of mice. Thus, although rotarod exercise does not induce systemic inflammation, it influences innate immunity-related responses in the brain, controls gene expression and, consequently, regulates anxiety and contextual learning and memory.http://www.sciencedirect.com/science/article/pii/S2589004221003527Molecular NeuroscienceImmunologyTranscriptomics |
| spellingShingle | Yun-Fen Hung Yi-Ping Hsueh TLR7 and IL-6 differentially regulate the effects of rotarod exercise on the transcriptomic profile and neurogenesis to influence anxiety and memory iScience Molecular Neuroscience Immunology Transcriptomics |
| title | TLR7 and IL-6 differentially regulate the effects of rotarod exercise on the transcriptomic profile and neurogenesis to influence anxiety and memory |
| title_full | TLR7 and IL-6 differentially regulate the effects of rotarod exercise on the transcriptomic profile and neurogenesis to influence anxiety and memory |
| title_fullStr | TLR7 and IL-6 differentially regulate the effects of rotarod exercise on the transcriptomic profile and neurogenesis to influence anxiety and memory |
| title_full_unstemmed | TLR7 and IL-6 differentially regulate the effects of rotarod exercise on the transcriptomic profile and neurogenesis to influence anxiety and memory |
| title_short | TLR7 and IL-6 differentially regulate the effects of rotarod exercise on the transcriptomic profile and neurogenesis to influence anxiety and memory |
| title_sort | tlr7 and il 6 differentially regulate the effects of rotarod exercise on the transcriptomic profile and neurogenesis to influence anxiety and memory |
| topic | Molecular Neuroscience Immunology Transcriptomics |
| url | http://www.sciencedirect.com/science/article/pii/S2589004221003527 |
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