Lipid Peroxidation Levels in Saliva and Plasma of Patients Suffering from Periodontitis
Lipid peroxidation (LPO) participates in the development of various diseases, including periodontitis, and malondialdehyde (MDA) is its terminal product. Therefore, in the present study, salivary and plasma MDA levels in 30 periodontitis patients were compared to those in 20 healthy controls, as wel...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/13/3617 |
| _version_ | 1797443075285450752 |
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| author | Tanja Veljovic Milanko Djuric Jelena Mirnic Ivana Gusic Aleksandra Maletin Bojana Ramic Isidora Neskovic Karolina Vukoje Snezana Brkic |
| author_facet | Tanja Veljovic Milanko Djuric Jelena Mirnic Ivana Gusic Aleksandra Maletin Bojana Ramic Isidora Neskovic Karolina Vukoje Snezana Brkic |
| author_sort | Tanja Veljovic |
| collection | DOAJ |
| description | Lipid peroxidation (LPO) participates in the development of various diseases, including periodontitis, and malondialdehyde (MDA) is its terminal product. Therefore, in the present study, salivary and plasma MDA levels in 30 periodontitis patients were compared to those in 20 healthy controls, as well as in relation to periodontal therapy in order to assess its effectiveness. Periodontal status was assessed via plaque index, gingival index, papilla bleeding index, probing depth and clinical attachment level, while salivary and plasma MDA levels were determined by the ELISA method. The periodontitis group had a significantly greater salivary (2.99 pmol/µL) and plasma (0.50 pmol/µL) MDA levels relative to the healthy controls (1.33 pmol/µL and 0.40 pmol/µL, respectively). Three months after the periodontal therapy completion, although salivary MDA levels were significantly lower than those measured at the baseline (<i>p</i> < 0.001), the reduction in plasma MDA was not statistically significant (<i>p</i> > 0.05). These findings indicate that, while inflammatory processes in periodontium may increase local and systemic lipid peroxidation, periodontal therapy can result in a significant decrease in salivary, but not plasma, MDA levels. |
| first_indexed | 2024-03-09T12:50:53Z |
| format | Article |
| id | doaj.art-56f44f626d86440bb9c644e0b715811d |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T12:50:53Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-56f44f626d86440bb9c644e0b715811d2023-11-30T22:06:18ZengMDPI AGJournal of Clinical Medicine2077-03832022-06-011113361710.3390/jcm11133617Lipid Peroxidation Levels in Saliva and Plasma of Patients Suffering from PeriodontitisTanja Veljovic0Milanko Djuric1Jelena Mirnic2Ivana Gusic3Aleksandra Maletin4Bojana Ramic5Isidora Neskovic6Karolina Vukoje7Snezana Brkic8Department of Dental Medicine, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, SerbiaDepartment of Dental Medicine, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, SerbiaDepartment of Dental Medicine, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, SerbiaDepartment of Dental Medicine, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, SerbiaDepartment of Dental Medicine, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, SerbiaDepartment of Dental Medicine, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, SerbiaDepartment of Dental Medicine, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, SerbiaDepartment of Dental Medicine, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, SerbiaDepartment of Dental Medicine, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, SerbiaLipid peroxidation (LPO) participates in the development of various diseases, including periodontitis, and malondialdehyde (MDA) is its terminal product. Therefore, in the present study, salivary and plasma MDA levels in 30 periodontitis patients were compared to those in 20 healthy controls, as well as in relation to periodontal therapy in order to assess its effectiveness. Periodontal status was assessed via plaque index, gingival index, papilla bleeding index, probing depth and clinical attachment level, while salivary and plasma MDA levels were determined by the ELISA method. The periodontitis group had a significantly greater salivary (2.99 pmol/µL) and plasma (0.50 pmol/µL) MDA levels relative to the healthy controls (1.33 pmol/µL and 0.40 pmol/µL, respectively). Three months after the periodontal therapy completion, although salivary MDA levels were significantly lower than those measured at the baseline (<i>p</i> < 0.001), the reduction in plasma MDA was not statistically significant (<i>p</i> > 0.05). These findings indicate that, while inflammatory processes in periodontium may increase local and systemic lipid peroxidation, periodontal therapy can result in a significant decrease in salivary, but not plasma, MDA levels.https://www.mdpi.com/2077-0383/11/13/3617malondialdehydeoxidative stressperiodontitisplasma |
| spellingShingle | Tanja Veljovic Milanko Djuric Jelena Mirnic Ivana Gusic Aleksandra Maletin Bojana Ramic Isidora Neskovic Karolina Vukoje Snezana Brkic Lipid Peroxidation Levels in Saliva and Plasma of Patients Suffering from Periodontitis Journal of Clinical Medicine malondialdehyde oxidative stress periodontitis plasma |
| title | Lipid Peroxidation Levels in Saliva and Plasma of Patients Suffering from Periodontitis |
| title_full | Lipid Peroxidation Levels in Saliva and Plasma of Patients Suffering from Periodontitis |
| title_fullStr | Lipid Peroxidation Levels in Saliva and Plasma of Patients Suffering from Periodontitis |
| title_full_unstemmed | Lipid Peroxidation Levels in Saliva and Plasma of Patients Suffering from Periodontitis |
| title_short | Lipid Peroxidation Levels in Saliva and Plasma of Patients Suffering from Periodontitis |
| title_sort | lipid peroxidation levels in saliva and plasma of patients suffering from periodontitis |
| topic | malondialdehyde oxidative stress periodontitis plasma |
| url | https://www.mdpi.com/2077-0383/11/13/3617 |
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