Crosstalk between SUMOylation and ubiquitylation controls DNA end resection by maintaining MRE11 homeostasis on chromatin
DNA end resection initiating DNA repair by homologous recombination needs to be delicately regulated. This study shows the interplay between SUMOylation and ubiquitylation maintains MRE11 homeostasis on chromatin, thus facilitating genome stability.
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32920-x |
| _version_ | 1817986888879833088 |
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| author | Tao Zhang Han Yang Zenan Zhou Yongtai Bai Jiadong Wang Weibin Wang |
| author_facet | Tao Zhang Han Yang Zenan Zhou Yongtai Bai Jiadong Wang Weibin Wang |
| author_sort | Tao Zhang |
| collection | DOAJ |
| description | DNA end resection initiating DNA repair by homologous recombination needs to be delicately regulated. This study shows the interplay between SUMOylation and ubiquitylation maintains MRE11 homeostasis on chromatin, thus facilitating genome stability. |
| first_indexed | 2024-04-14T00:15:01Z |
| format | Article |
| id | doaj.art-56f4cfff446241919ef9ee6a6d64fc1b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-14T00:15:01Z |
| publishDate | 2022-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-56f4cfff446241919ef9ee6a6d64fc1b2022-12-22T02:23:09ZengNature PortfolioNature Communications2041-17232022-09-0113111710.1038/s41467-022-32920-xCrosstalk between SUMOylation and ubiquitylation controls DNA end resection by maintaining MRE11 homeostasis on chromatinTao Zhang0Han Yang1Zenan Zhou2Yongtai Bai3Jiadong Wang4Weibin Wang5Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science CenterDepartment of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science CenterDepartment of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science CenterDepartment of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science CenterDepartment of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science CenterDepartment of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science CenterDNA end resection initiating DNA repair by homologous recombination needs to be delicately regulated. This study shows the interplay between SUMOylation and ubiquitylation maintains MRE11 homeostasis on chromatin, thus facilitating genome stability.https://doi.org/10.1038/s41467-022-32920-x |
| spellingShingle | Tao Zhang Han Yang Zenan Zhou Yongtai Bai Jiadong Wang Weibin Wang Crosstalk between SUMOylation and ubiquitylation controls DNA end resection by maintaining MRE11 homeostasis on chromatin Nature Communications |
| title | Crosstalk between SUMOylation and ubiquitylation controls DNA end resection by maintaining MRE11 homeostasis on chromatin |
| title_full | Crosstalk between SUMOylation and ubiquitylation controls DNA end resection by maintaining MRE11 homeostasis on chromatin |
| title_fullStr | Crosstalk between SUMOylation and ubiquitylation controls DNA end resection by maintaining MRE11 homeostasis on chromatin |
| title_full_unstemmed | Crosstalk between SUMOylation and ubiquitylation controls DNA end resection by maintaining MRE11 homeostasis on chromatin |
| title_short | Crosstalk between SUMOylation and ubiquitylation controls DNA end resection by maintaining MRE11 homeostasis on chromatin |
| title_sort | crosstalk between sumoylation and ubiquitylation controls dna end resection by maintaining mre11 homeostasis on chromatin |
| url | https://doi.org/10.1038/s41467-022-32920-x |
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