Comparison of transepithelial cytology and histopathology in the diagnosis of potentially malignant and malignant lesions of the oral mucosa
Background/Aim: The objective of the study was to compare cytological diagnoses using transepithelial cytology (oral brush biopsy) with histopathological diagnoses obtained by incisional biopsy in patients with benign lesions, oral potentially malignant disorders and oral squamous cell carcinoma. Ma...
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| Format: | Article |
| Language: | English |
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Balkan Stomatological Society
2022-01-01
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| Series: | Balkan Journal of Dental Medicine |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/2335-0245/2022/2335-02452202113T.pdf |
| _version_ | 1828400740051189760 |
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| author | Tomić Uroš Petrović Sanja Soldatović Ivan Mihailović Đorđe Kuzmanović Čedomir Jelovac Drago Tomanović Nada Pucar Ana |
| author_facet | Tomić Uroš Petrović Sanja Soldatović Ivan Mihailović Đorđe Kuzmanović Čedomir Jelovac Drago Tomanović Nada Pucar Ana |
| author_sort | Tomić Uroš |
| collection | DOAJ |
| description | Background/Aim: The objective of the study was to compare cytological diagnoses using transepithelial cytology (oral brush biopsy) with histopathological diagnoses obtained by incisional biopsy in patients with benign lesions, oral potentially malignant disorders and oral squamous cell carcinoma. Material and Methods: The study included 57 patients. Brush biopsy was performed after local anaesthesia administration using the cervical brush. It was immediately followed by an incisional biopsy. Modified Bethesda System was used for cytological analysis and correlated with histopathological diagnoses according to intraepithelial neoplasia. Results: Good agreement was shown between cytological and histopathological diagnosis (kappa = 0.791). The sensitivity of the study was 92.85%, specificity 100%, positive predictive value (PPV) was 100% and negative predictive value (NPV) 93.54%. Conclusions: Oral brush biopsy, which allows the collection of epithelial cells of all layers can provide fast, precise and efficient cytological results which are in good agreement with the 'gold standard' - incisional biopsy followed by histopathology. |
| first_indexed | 2024-12-10T09:36:28Z |
| format | Article |
| id | doaj.art-56f53e72b8ea407d985ea1b3f3ede1f6 |
| institution | Directory Open Access Journal |
| issn | 2335-0245 |
| language | English |
| last_indexed | 2024-12-10T09:36:28Z |
| publishDate | 2022-01-01 |
| publisher | Balkan Stomatological Society |
| record_format | Article |
| series | Balkan Journal of Dental Medicine |
| spelling | doaj.art-56f53e72b8ea407d985ea1b3f3ede1f62022-12-22T01:54:10ZengBalkan Stomatological SocietyBalkan Journal of Dental Medicine2335-02452022-01-0126211311710.5937/bjdm20220531-0012335-02452202113TComparison of transepithelial cytology and histopathology in the diagnosis of potentially malignant and malignant lesions of the oral mucosaTomić Uroš0Petrović Sanja1Soldatović Ivan2https://orcid.org/0000-0003-4893-1683Mihailović Đorđe3Kuzmanović Čedomir4Jelovac Drago5https://orcid.org/0000-0002-4236-4967Tomanović Nada6Pucar Ana7University of Belgrade, School of Dental Medicine, Department of Oral Medicine and Periodontology, Belgrade, SerbiaUniversity of Belgrade, School of Dental Medicine, Department of Oral Medicine and Periodontology, Belgrade, SerbiaUniversity of Belgrade, Faculty of Medicine, Institute for Biostatistics, Medical Informatics and Research in Medicine, Belgrade, SerbiaUniversity of Pristina/Kosovska Mitrovica, Faculty of Medicine, Dentistry Clinic, Kosovska Mitrovica, SerbiaUniversity of Belgrade, School of Dental Medicine, Clinic for Maxillofacial Surgery, Belgrade, SerbiaUniversity of Belgrade, School of Dental Medicine, Clinic for Maxillofacial Surgery, Belgrade, SerbiaUniversity of Belgrade, Faculty of Medicine, Institute of Pathology, Belgrade, SerbiaUniversity of Belgrade, School of Dental Medicine, Department of Oral Medicine and Periodontology, Belgrade, SerbiaBackground/Aim: The objective of the study was to compare cytological diagnoses using transepithelial cytology (oral brush biopsy) with histopathological diagnoses obtained by incisional biopsy in patients with benign lesions, oral potentially malignant disorders and oral squamous cell carcinoma. Material and Methods: The study included 57 patients. Brush biopsy was performed after local anaesthesia administration using the cervical brush. It was immediately followed by an incisional biopsy. Modified Bethesda System was used for cytological analysis and correlated with histopathological diagnoses according to intraepithelial neoplasia. Results: Good agreement was shown between cytological and histopathological diagnosis (kappa = 0.791). The sensitivity of the study was 92.85%, specificity 100%, positive predictive value (PPV) was 100% and negative predictive value (NPV) 93.54%. Conclusions: Oral brush biopsy, which allows the collection of epithelial cells of all layers can provide fast, precise and efficient cytological results which are in good agreement with the 'gold standard' - incisional biopsy followed by histopathology.https://scindeks-clanci.ceon.rs/data/pdf/2335-0245/2022/2335-02452202113T.pdfincisional biopsyoral brush biopsyoral carcinomaoral potentially malignant disordertransepithelial cytology |
| spellingShingle | Tomić Uroš Petrović Sanja Soldatović Ivan Mihailović Đorđe Kuzmanović Čedomir Jelovac Drago Tomanović Nada Pucar Ana Comparison of transepithelial cytology and histopathology in the diagnosis of potentially malignant and malignant lesions of the oral mucosa Balkan Journal of Dental Medicine incisional biopsy oral brush biopsy oral carcinoma oral potentially malignant disorder transepithelial cytology |
| title | Comparison of transepithelial cytology and histopathology in the diagnosis of potentially malignant and malignant lesions of the oral mucosa |
| title_full | Comparison of transepithelial cytology and histopathology in the diagnosis of potentially malignant and malignant lesions of the oral mucosa |
| title_fullStr | Comparison of transepithelial cytology and histopathology in the diagnosis of potentially malignant and malignant lesions of the oral mucosa |
| title_full_unstemmed | Comparison of transepithelial cytology and histopathology in the diagnosis of potentially malignant and malignant lesions of the oral mucosa |
| title_short | Comparison of transepithelial cytology and histopathology in the diagnosis of potentially malignant and malignant lesions of the oral mucosa |
| title_sort | comparison of transepithelial cytology and histopathology in the diagnosis of potentially malignant and malignant lesions of the oral mucosa |
| topic | incisional biopsy oral brush biopsy oral carcinoma oral potentially malignant disorder transepithelial cytology |
| url | https://scindeks-clanci.ceon.rs/data/pdf/2335-0245/2022/2335-02452202113T.pdf |
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