Effects of thickened drinks on the disintegration of various oral tablets
Food thickeners are widely used to aid the oral administration of medications to patients with dysphagia. Powder-type food thickeners are used to modulate the viscosity of therapeutic solutions depending on the swallowing capacity of patients. Food thickeners inhibit or delay the disintegration of s...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-12-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844020326438 |
| _version_ | 1819296482174435328 |
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| author | Taisuke Matsuo Chinatsu Sato Takashi Tomita Yasuyuki Sadzuka |
| author_facet | Taisuke Matsuo Chinatsu Sato Takashi Tomita Yasuyuki Sadzuka |
| author_sort | Taisuke Matsuo |
| collection | DOAJ |
| description | Food thickeners are widely used to aid the oral administration of medications to patients with dysphagia. Powder-type food thickeners are used to modulate the viscosity of therapeutic solutions depending on the swallowing capacity of patients. Food thickeners inhibit or delay the disintegration of some medications, resulting in reduced pharmaceutical effects of the medications and/or their excretion in the stool. A short immersion time (within 1 min) is important to overcome these problems. Although thickened drinks are commercially available, their use as vehicles for medications is not well understood. In this study, we evaluated the effects of thickened drinks on the disintegration time of therapeutic tablets. Furthermore, we compared the thickened drinks with powder-type xanthan gum-based food thickeners. Forty tablets were used, including naked tablets, film-coated tablets, orally disintegrating tablets, enteric-coated tablets, and sugar-coated tablets. For the disintegration test, the tablets were immersed in thickened drinks or food thickeners for 1 min. The changes in the disintegration time of the 40 tablets immersed in the thickened drinks were comparable with those in food thickeners. The disintegration time of several tablets was shorter or unchanged after immersion in the thickened drinks. The disintegration time of rapidly disintegrating tablets tended to increase when immersed in thickened drinks, but it was less than 2 min for the majority of the tablets. These results demonstrate that thickened drinks, similar to food thickeners, could help administer medications to patients. Overall, our study provides valuable information for pharmacists and clinicians to decide the most suitable way to deliver medications to patients with dysphagia. |
| first_indexed | 2024-12-24T04:58:48Z |
| format | Article |
| id | doaj.art-56f59109d58b420da1e7c326e4fd6edc |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-24T04:58:48Z |
| publishDate | 2020-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-56f59109d58b420da1e7c326e4fd6edc2022-12-21T17:14:18ZengElsevierHeliyon2405-84402020-12-01612e05800Effects of thickened drinks on the disintegration of various oral tabletsTaisuke Matsuo0Chinatsu Sato1Takashi Tomita2Yasuyuki Sadzuka3Division of Advanced Pharmaceutics, Department of Clinical Pharmaceutical Sciences, School of Pharmacy, Iwate Medical University; 1-1-1 Idaidori, Yahaba-cho, Shiwa-gun, Iwate 028-3694, Japan; Corresponding author.Division of Advanced Pharmaceutics, Department of Clinical Pharmaceutical Sciences, School of Pharmacy, Iwate Medical University; 1-1-1 Idaidori, Yahaba-cho, Shiwa-gun, Iwate 028-3694, JapanDepartment of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Teikyo Heisei University; 4-21-2, Nakano, Nakano-ku, Tokyo 164-8530, JapanDivision of Advanced Pharmaceutics, Department of Clinical Pharmaceutical Sciences, School of Pharmacy, Iwate Medical University; 1-1-1 Idaidori, Yahaba-cho, Shiwa-gun, Iwate 028-3694, JapanFood thickeners are widely used to aid the oral administration of medications to patients with dysphagia. Powder-type food thickeners are used to modulate the viscosity of therapeutic solutions depending on the swallowing capacity of patients. Food thickeners inhibit or delay the disintegration of some medications, resulting in reduced pharmaceutical effects of the medications and/or their excretion in the stool. A short immersion time (within 1 min) is important to overcome these problems. Although thickened drinks are commercially available, their use as vehicles for medications is not well understood. In this study, we evaluated the effects of thickened drinks on the disintegration time of therapeutic tablets. Furthermore, we compared the thickened drinks with powder-type xanthan gum-based food thickeners. Forty tablets were used, including naked tablets, film-coated tablets, orally disintegrating tablets, enteric-coated tablets, and sugar-coated tablets. For the disintegration test, the tablets were immersed in thickened drinks or food thickeners for 1 min. The changes in the disintegration time of the 40 tablets immersed in the thickened drinks were comparable with those in food thickeners. The disintegration time of several tablets was shorter or unchanged after immersion in the thickened drinks. The disintegration time of rapidly disintegrating tablets tended to increase when immersed in thickened drinks, but it was less than 2 min for the majority of the tablets. These results demonstrate that thickened drinks, similar to food thickeners, could help administer medications to patients. Overall, our study provides valuable information for pharmacists and clinicians to decide the most suitable way to deliver medications to patients with dysphagia.http://www.sciencedirect.com/science/article/pii/S2405844020326438Disintegration timeDysphagiaFood thickenerTabletThickened drinkXanthan gum |
| spellingShingle | Taisuke Matsuo Chinatsu Sato Takashi Tomita Yasuyuki Sadzuka Effects of thickened drinks on the disintegration of various oral tablets Heliyon Disintegration time Dysphagia Food thickener Tablet Thickened drink Xanthan gum |
| title | Effects of thickened drinks on the disintegration of various oral tablets |
| title_full | Effects of thickened drinks on the disintegration of various oral tablets |
| title_fullStr | Effects of thickened drinks on the disintegration of various oral tablets |
| title_full_unstemmed | Effects of thickened drinks on the disintegration of various oral tablets |
| title_short | Effects of thickened drinks on the disintegration of various oral tablets |
| title_sort | effects of thickened drinks on the disintegration of various oral tablets |
| topic | Disintegration time Dysphagia Food thickener Tablet Thickened drink Xanthan gum |
| url | http://www.sciencedirect.com/science/article/pii/S2405844020326438 |
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