Association of non‐invasive electrocardiographic risk factors with left ventricular systolic function in post‐myocardial infarction patients with mildly reduced or preserved ejection fraction: Insights from the PRESERVE‐EF study
Abstract Background Electrocardiographic non‐invasive risk factors (NIRFs) have an important role in the arrhythmic risk stratification of post‐myocardial infarction (post‐MI) patients with preserved or mildly reduced left ventricular ejection fraction (LVEF). However, their specific relation to lef...
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| Format: | Article |
| Language: | English |
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Wiley
2022-09-01
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| Series: | Annals of Noninvasive Electrocardiology |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/anec.12946 |
| _version_ | 1828147688264171520 |
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| author | Konstantinos P. Tsimos Panagiotis Korantzopoulos Petros Arsenos Ioannis Doundoulakis Dimitrios Tsiachris Christos‐Konstantinos Antoniou Konstantinos Krikonis Skevos Sideris Polychronis Dilaveris Konstantinos Triantafyllou Stergios Soulaidopoulos Emmanuel Kanoupakis Nikolaos Fragakis Antonios Sideris Konstantinos Trachanas Efstathios Iliodromitis Dimitrios Tousoulis Konstantinos Tsioufis Theofilos M. Kolettis Konstantinos A. Gatzoulis |
| author_facet | Konstantinos P. Tsimos Panagiotis Korantzopoulos Petros Arsenos Ioannis Doundoulakis Dimitrios Tsiachris Christos‐Konstantinos Antoniou Konstantinos Krikonis Skevos Sideris Polychronis Dilaveris Konstantinos Triantafyllou Stergios Soulaidopoulos Emmanuel Kanoupakis Nikolaos Fragakis Antonios Sideris Konstantinos Trachanas Efstathios Iliodromitis Dimitrios Tousoulis Konstantinos Tsioufis Theofilos M. Kolettis Konstantinos A. Gatzoulis |
| author_sort | Konstantinos P. Tsimos |
| collection | DOAJ |
| description | Abstract Background Electrocardiographic non‐invasive risk factors (NIRFs) have an important role in the arrhythmic risk stratification of post‐myocardial infarction (post‐MI) patients with preserved or mildly reduced left ventricular ejection fraction (LVEF). However, their specific relation to left ventricular systolic function remains unclear. We aimed to evaluate the association between NIRFs and LVEF in the patients included in the PRESERVE‐EF trial. Methods We studied 575 post‐MI ischemia‐free patients with LVEF≥40% (mean age: 57.0 ± 10.4 years, 86.2% men). The following NIRFs were evaluated: premature ventricular complexes, non‐sustained ventricular tachycardia (NSVT), late potentials (LPs), prolonged QTc, increased T‐wave alternans, reduced heart rate variability, and abnormal deceleration capacity with abnormal turbulence. Results There was a statistically significant relationship between LPs (Chi‐squared = 4.975; p < .05), nsVT (Chi‐squared = 5.749, p < .05), PVCs (r= −.136; p < .01), and the LVEF. The multivariate linear regression analysis showed that LPs (p = .001) and NSVT (p < .001) were significant predictors of the LVEF. The results of the multivariate logistic regression analysis indicated that LPs (OR: 1.76; 95% CI: 1.02–3.05; p = .004) and NSVT (OR: 2.44; 95% CI: 1.18–5.04; p = .001) were independent predictors of the mildly reduced LVEF: 40%–49% versus the preserved LVEF: ≥50%. Conclusion Late potentials and NSVT are independently related to reduced LVEF while they are independent predictors of mildly reduced LVEF versus the preserved LVEF. These findings may have important implications for the arrhythmic risk stratification of post‐MI patients with mildly reduced or preserved LVEF. |
| first_indexed | 2024-04-11T21:03:54Z |
| format | Article |
| id | doaj.art-56f63d5919d44f93b1362bc352c3c05b |
| institution | Directory Open Access Journal |
| issn | 1082-720X 1542-474X |
| language | English |
| last_indexed | 2024-04-11T21:03:54Z |
| publishDate | 2022-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Noninvasive Electrocardiology |
| spelling | doaj.art-56f63d5919d44f93b1362bc352c3c05b2022-12-22T04:03:24ZengWileyAnnals of Noninvasive Electrocardiology1082-720X1542-474X2022-09-01275n/an/a10.1111/anec.12946Association of non‐invasive electrocardiographic risk factors with left ventricular systolic function in post‐myocardial infarction patients with mildly reduced or preserved ejection fraction: Insights from the PRESERVE‐EF studyKonstantinos P. Tsimos0Panagiotis Korantzopoulos1Petros Arsenos2Ioannis Doundoulakis3Dimitrios Tsiachris4Christos‐Konstantinos Antoniou5Konstantinos Krikonis6Skevos Sideris7Polychronis Dilaveris8Konstantinos Triantafyllou9Stergios Soulaidopoulos10Emmanuel Kanoupakis11Nikolaos Fragakis12Antonios Sideris13Konstantinos Trachanas14Efstathios Iliodromitis15Dimitrios Tousoulis16Konstantinos Tsioufis17Theofilos M. Kolettis18Konstantinos A. Gatzoulis19First Department of Cardiology University of Ioannina Medical School Ioannina GreeceFirst Department of Cardiology University of Ioannina Medical School Ioannina GreeceFirst Department of Cardiology Hippokrateion Hospital National and Kapodistrian University of Athens Athens GreeceFirst Department of Cardiology Hippokrateion Hospital National and Kapodistrian University of Athens Athens GreeceFirst Department of Cardiology Hippokrateion Hospital National and Kapodistrian University of Athens Athens GreeceFirst Department of Cardiology Hippokrateion Hospital National and Kapodistrian University of Athens Athens GreeceDatAnalysis Ioannina GreeceState Department of Cardiology Hippokrateion General Hospital Athens GreeceFirst Department of Cardiology Hippokrateion Hospital National and Kapodistrian University of Athens Athens GreeceThird Department of Cardiology Aristotle University of Thessaloniki Thessaloniki GreeceFirst Department of Cardiology Hippokrateion Hospital National and Kapodistrian University of Athens Athens GreeceDepartment of Cardiology School of Medicine Heraklion University Hospital University of Crete Heraklion GreeceThird Department of Cardiology Aristotle University of Thessaloniki Thessaloniki GreeceSecond State Department of Cardiology Evangelismos Athens General Hospital Athens GreeceState Department of Cardiology Hippokrateion General Hospital Athens GreeceSecond Cardiology Department Attikon Hospital National and Kapodistrian University of Athens Athens GreeceFirst Department of Cardiology Hippokrateion Hospital National and Kapodistrian University of Athens Athens GreeceFirst Department of Cardiology Hippokrateion Hospital National and Kapodistrian University of Athens Athens GreeceFirst Department of Cardiology University of Ioannina Medical School Ioannina GreeceFirst Department of Cardiology Hippokrateion Hospital National and Kapodistrian University of Athens Athens GreeceAbstract Background Electrocardiographic non‐invasive risk factors (NIRFs) have an important role in the arrhythmic risk stratification of post‐myocardial infarction (post‐MI) patients with preserved or mildly reduced left ventricular ejection fraction (LVEF). However, their specific relation to left ventricular systolic function remains unclear. We aimed to evaluate the association between NIRFs and LVEF in the patients included in the PRESERVE‐EF trial. Methods We studied 575 post‐MI ischemia‐free patients with LVEF≥40% (mean age: 57.0 ± 10.4 years, 86.2% men). The following NIRFs were evaluated: premature ventricular complexes, non‐sustained ventricular tachycardia (NSVT), late potentials (LPs), prolonged QTc, increased T‐wave alternans, reduced heart rate variability, and abnormal deceleration capacity with abnormal turbulence. Results There was a statistically significant relationship between LPs (Chi‐squared = 4.975; p < .05), nsVT (Chi‐squared = 5.749, p < .05), PVCs (r= −.136; p < .01), and the LVEF. The multivariate linear regression analysis showed that LPs (p = .001) and NSVT (p < .001) were significant predictors of the LVEF. The results of the multivariate logistic regression analysis indicated that LPs (OR: 1.76; 95% CI: 1.02–3.05; p = .004) and NSVT (OR: 2.44; 95% CI: 1.18–5.04; p = .001) were independent predictors of the mildly reduced LVEF: 40%–49% versus the preserved LVEF: ≥50%. Conclusion Late potentials and NSVT are independently related to reduced LVEF while they are independent predictors of mildly reduced LVEF versus the preserved LVEF. These findings may have important implications for the arrhythmic risk stratification of post‐MI patients with mildly reduced or preserved LVEF.https://doi.org/10.1111/anec.12946late potentialsleft ventricular ejection fractionnon‐invasive risk factorsnon‐sustained ventricular tachycardiarisk stratification |
| spellingShingle | Konstantinos P. Tsimos Panagiotis Korantzopoulos Petros Arsenos Ioannis Doundoulakis Dimitrios Tsiachris Christos‐Konstantinos Antoniou Konstantinos Krikonis Skevos Sideris Polychronis Dilaveris Konstantinos Triantafyllou Stergios Soulaidopoulos Emmanuel Kanoupakis Nikolaos Fragakis Antonios Sideris Konstantinos Trachanas Efstathios Iliodromitis Dimitrios Tousoulis Konstantinos Tsioufis Theofilos M. Kolettis Konstantinos A. Gatzoulis Association of non‐invasive electrocardiographic risk factors with left ventricular systolic function in post‐myocardial infarction patients with mildly reduced or preserved ejection fraction: Insights from the PRESERVE‐EF study Annals of Noninvasive Electrocardiology late potentials left ventricular ejection fraction non‐invasive risk factors non‐sustained ventricular tachycardia risk stratification |
| title | Association of non‐invasive electrocardiographic risk factors with left ventricular systolic function in post‐myocardial infarction patients with mildly reduced or preserved ejection fraction: Insights from the PRESERVE‐EF study |
| title_full | Association of non‐invasive electrocardiographic risk factors with left ventricular systolic function in post‐myocardial infarction patients with mildly reduced or preserved ejection fraction: Insights from the PRESERVE‐EF study |
| title_fullStr | Association of non‐invasive electrocardiographic risk factors with left ventricular systolic function in post‐myocardial infarction patients with mildly reduced or preserved ejection fraction: Insights from the PRESERVE‐EF study |
| title_full_unstemmed | Association of non‐invasive electrocardiographic risk factors with left ventricular systolic function in post‐myocardial infarction patients with mildly reduced or preserved ejection fraction: Insights from the PRESERVE‐EF study |
| title_short | Association of non‐invasive electrocardiographic risk factors with left ventricular systolic function in post‐myocardial infarction patients with mildly reduced or preserved ejection fraction: Insights from the PRESERVE‐EF study |
| title_sort | association of non invasive electrocardiographic risk factors with left ventricular systolic function in post myocardial infarction patients with mildly reduced or preserved ejection fraction insights from the preserve ef study |
| topic | late potentials left ventricular ejection fraction non‐invasive risk factors non‐sustained ventricular tachycardia risk stratification |
| url | https://doi.org/10.1111/anec.12946 |
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