Preparation and Application of Decellularized ECM-Based Biological Scaffolds for Articular Cartilage Repair: A Review
Cartilage regeneration is dependent on cellular-extracellular matrix (ECM) interactions. Natural ECM plays a role in mechanical and chemical cell signaling and promotes stem cell recruitment, differentiation and tissue regeneration in the absence of biological additives, including growth factors and...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.908082/full |
| _version_ | 1811227782354567168 |
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| author | Qian Zhang Yixin Hu Xuan Long Lingling Hu Yu Wu Ji Wu Xiaobing Shi Runqi Xie Yu Bi Fangyuan Yu Pinxue Li Yu Yang |
| author_facet | Qian Zhang Yixin Hu Xuan Long Lingling Hu Yu Wu Ji Wu Xiaobing Shi Runqi Xie Yu Bi Fangyuan Yu Pinxue Li Yu Yang |
| author_sort | Qian Zhang |
| collection | DOAJ |
| description | Cartilage regeneration is dependent on cellular-extracellular matrix (ECM) interactions. Natural ECM plays a role in mechanical and chemical cell signaling and promotes stem cell recruitment, differentiation and tissue regeneration in the absence of biological additives, including growth factors and peptides. To date, traditional tissue engineering methods by using natural and synthetic materials have not been able to replicate the physiological structure (biochemical composition and biomechanical properties) of natural cartilage. Techniques facilitating the repair and/or regeneration of articular cartilage pose a significant challenge for orthopedic surgeons. Whereas, little progress has been made in this field. In recent years, with advances in medicine, biochemistry and materials science, to meet the regenerative requirements of the heterogeneous and layered structure of native articular cartilage (AC) tissue, a series of tissue engineering scaffolds based on ECM materials have been developed. These scaffolds mimic the versatility of the native ECM in function, composition and dynamic properties and some of which are designed to improve cartilage regeneration. This review systematically investigates the following: the characteristics of cartilage ECM, repair mechanisms, decellularization method, source of ECM, and various ECM-based cartilage repair methods. In addition, the future development of ECM-based biomaterials is hypothesized. |
| first_indexed | 2024-04-12T09:47:31Z |
| format | Article |
| id | doaj.art-56f66d9bc8024969afa82ffbb18b757a |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-12T09:47:31Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-56f66d9bc8024969afa82ffbb18b757a2022-12-22T03:37:54ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-06-011010.3389/fbioe.2022.908082908082Preparation and Application of Decellularized ECM-Based Biological Scaffolds for Articular Cartilage Repair: A ReviewQian Zhang0Yixin Hu1Xuan Long2Lingling Hu3Yu Wu4Ji Wu5Xiaobing Shi6Runqi Xie7Yu Bi8Fangyuan Yu9Pinxue Li10Yu Yang11Department of Orthopedics, The Second People’s Hospital of Guiyang, Guiyang, ChinaDepartment of Orthopedics, The Second People’s Hospital of Guiyang, Guiyang, ChinaDepartment of Obstetrics and Gynecology, Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaDepartment of Orthopedics, The Second People’s Hospital of Guiyang, Guiyang, ChinaDepartment of Orthopedics, The Second People’s Hospital of Guiyang, Guiyang, ChinaDepartment of Orthopedics, The Second People’s Hospital of Guiyang, Guiyang, ChinaDepartment of Orthopedics, The Second People’s Hospital of Guiyang, Guiyang, ChinaDepartment of Orthopedics, The Second People’s Hospital of Guiyang, Guiyang, ChinaDepartment of Orthopedics, The Second People’s Hospital of Guiyang, Guiyang, ChinaSenior Department of Orthopedics, Forth Medical Center of Chinese PLA General Hospital, Beijing, ChinaSchool of Medicine, Nankai University, Tianjin, ChinaDepartment of Orthopedics, The Second People’s Hospital of Guiyang, Guiyang, ChinaCartilage regeneration is dependent on cellular-extracellular matrix (ECM) interactions. Natural ECM plays a role in mechanical and chemical cell signaling and promotes stem cell recruitment, differentiation and tissue regeneration in the absence of biological additives, including growth factors and peptides. To date, traditional tissue engineering methods by using natural and synthetic materials have not been able to replicate the physiological structure (biochemical composition and biomechanical properties) of natural cartilage. Techniques facilitating the repair and/or regeneration of articular cartilage pose a significant challenge for orthopedic surgeons. Whereas, little progress has been made in this field. In recent years, with advances in medicine, biochemistry and materials science, to meet the regenerative requirements of the heterogeneous and layered structure of native articular cartilage (AC) tissue, a series of tissue engineering scaffolds based on ECM materials have been developed. These scaffolds mimic the versatility of the native ECM in function, composition and dynamic properties and some of which are designed to improve cartilage regeneration. This review systematically investigates the following: the characteristics of cartilage ECM, repair mechanisms, decellularization method, source of ECM, and various ECM-based cartilage repair methods. In addition, the future development of ECM-based biomaterials is hypothesized.https://www.frontiersin.org/articles/10.3389/fbioe.2022.908082/fullextracellular matrixmesenchymal stem cellstissue engineeringdecellularizationarticular cartilage regeneration |
| spellingShingle | Qian Zhang Yixin Hu Xuan Long Lingling Hu Yu Wu Ji Wu Xiaobing Shi Runqi Xie Yu Bi Fangyuan Yu Pinxue Li Yu Yang Preparation and Application of Decellularized ECM-Based Biological Scaffolds for Articular Cartilage Repair: A Review Frontiers in Bioengineering and Biotechnology extracellular matrix mesenchymal stem cells tissue engineering decellularization articular cartilage regeneration |
| title | Preparation and Application of Decellularized ECM-Based Biological Scaffolds for Articular Cartilage Repair: A Review |
| title_full | Preparation and Application of Decellularized ECM-Based Biological Scaffolds for Articular Cartilage Repair: A Review |
| title_fullStr | Preparation and Application of Decellularized ECM-Based Biological Scaffolds for Articular Cartilage Repair: A Review |
| title_full_unstemmed | Preparation and Application of Decellularized ECM-Based Biological Scaffolds for Articular Cartilage Repair: A Review |
| title_short | Preparation and Application of Decellularized ECM-Based Biological Scaffolds for Articular Cartilage Repair: A Review |
| title_sort | preparation and application of decellularized ecm based biological scaffolds for articular cartilage repair a review |
| topic | extracellular matrix mesenchymal stem cells tissue engineering decellularization articular cartilage regeneration |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.908082/full |
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