Genotoxic Assessment of Nutraceuticals Obtained from Agricultural Biowaste: Where Do We “<i>AMES</i>”?
Several pharmaceutical companies are nowadays considering the use of agri-food waste as alternative raw material for the extraction of bioactive compounds to include in nutraceuticals and food supplements. This recycling activity is encountering the support of authorities, which are alarmed by air,...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/11/6/1197 |
| _version_ | 1797490464337690624 |
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| author | Giorgia Musto Valentina Laurenzi Giuseppe Annunziata Ettore Novellino Mariano Stornaiuolo |
| author_facet | Giorgia Musto Valentina Laurenzi Giuseppe Annunziata Ettore Novellino Mariano Stornaiuolo |
| author_sort | Giorgia Musto |
| collection | DOAJ |
| description | Several pharmaceutical companies are nowadays considering the use of agri-food waste as alternative raw material for the extraction of bioactive compounds to include in nutraceuticals and food supplements. This recycling activity is encountering the support of authorities, which are alarmed by air, soil and water pollution generated by agricultural waste disposal. Waste reuse has several economic advantages: (i) its low cost; (ii) its abundance; (iii) the high content of bioactive molecule (antioxidants, minerals, fibers, fatty acids); as well as (iv) the financial support received by governments eager to promote eco-compatible and pollution-reducing practices. While nutraceuticals produced from biowaste are becoming popular, products that have been risk-assessed in terms of safety are quite rare. This despite waste biomass, in virtue of its chemical complexity, could, in many cases, mine the overall safety of the final nutraceutical product. In this review, we summarize the scientific results published on genotoxicity risk-assessment of bioactive compounds extracted from agricultural waste. The review depicts a scenario where the risk-assessment of biowaste derived products is still scarcely diffuse, but when available, it confirms the safety of these products, and lets us envisage their future inclusion in the list of botanicals allowed for formulation intended for human consumption. |
| first_indexed | 2024-03-10T00:33:21Z |
| format | Article |
| id | doaj.art-56f80588f1f54bddb4a8e248e86e6dbe |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T00:33:21Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-56f80588f1f54bddb4a8e248e86e6dbe2023-11-23T15:21:16ZengMDPI AGAntioxidants2076-39212022-06-01116119710.3390/antiox11061197Genotoxic Assessment of Nutraceuticals Obtained from Agricultural Biowaste: Where Do We “<i>AMES</i>”?Giorgia Musto0Valentina Laurenzi1Giuseppe Annunziata2Ettore Novellino3Mariano Stornaiuolo4Department of Pharmacy, University of Naples Federico II, Via Montesano 49, 80131 Naples, ItalyDepartment of Pharmacy, University of Naples Federico II, Via Montesano 49, 80131 Naples, ItalyDepartment of Pharmacy, University of Naples Federico II, Via Montesano 49, 80131 Naples, ItalyDepartment of Medicine and Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyDepartment of Pharmacy, University of Naples Federico II, Via Montesano 49, 80131 Naples, ItalySeveral pharmaceutical companies are nowadays considering the use of agri-food waste as alternative raw material for the extraction of bioactive compounds to include in nutraceuticals and food supplements. This recycling activity is encountering the support of authorities, which are alarmed by air, soil and water pollution generated by agricultural waste disposal. Waste reuse has several economic advantages: (i) its low cost; (ii) its abundance; (iii) the high content of bioactive molecule (antioxidants, minerals, fibers, fatty acids); as well as (iv) the financial support received by governments eager to promote eco-compatible and pollution-reducing practices. While nutraceuticals produced from biowaste are becoming popular, products that have been risk-assessed in terms of safety are quite rare. This despite waste biomass, in virtue of its chemical complexity, could, in many cases, mine the overall safety of the final nutraceutical product. In this review, we summarize the scientific results published on genotoxicity risk-assessment of bioactive compounds extracted from agricultural waste. The review depicts a scenario where the risk-assessment of biowaste derived products is still scarcely diffuse, but when available, it confirms the safety of these products, and lets us envisage their future inclusion in the list of botanicals allowed for formulation intended for human consumption.https://www.mdpi.com/2076-3921/11/6/1197recyclingbiowasteagricultural by-productsgenotoxicitynutraceuticalscircular economy |
| spellingShingle | Giorgia Musto Valentina Laurenzi Giuseppe Annunziata Ettore Novellino Mariano Stornaiuolo Genotoxic Assessment of Nutraceuticals Obtained from Agricultural Biowaste: Where Do We “<i>AMES</i>”? Antioxidants recycling biowaste agricultural by-products genotoxicity nutraceuticals circular economy |
| title | Genotoxic Assessment of Nutraceuticals Obtained from Agricultural Biowaste: Where Do We “<i>AMES</i>”? |
| title_full | Genotoxic Assessment of Nutraceuticals Obtained from Agricultural Biowaste: Where Do We “<i>AMES</i>”? |
| title_fullStr | Genotoxic Assessment of Nutraceuticals Obtained from Agricultural Biowaste: Where Do We “<i>AMES</i>”? |
| title_full_unstemmed | Genotoxic Assessment of Nutraceuticals Obtained from Agricultural Biowaste: Where Do We “<i>AMES</i>”? |
| title_short | Genotoxic Assessment of Nutraceuticals Obtained from Agricultural Biowaste: Where Do We “<i>AMES</i>”? |
| title_sort | genotoxic assessment of nutraceuticals obtained from agricultural biowaste where do we i ames i |
| topic | recycling biowaste agricultural by-products genotoxicity nutraceuticals circular economy |
| url | https://www.mdpi.com/2076-3921/11/6/1197 |
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