Patient and healthcare team recommended medication adherence strategies for hydroxychloroquine: results of a qualitative study informing intervention development
Objective Patients identified as black and from disadvantaged backgrounds have a twofold higher hydroxychloroquine (HCQ) non-adherence, which contributes to worse lupus outcomes and disparities. Yet, most adherence interventions lack tailored strategies for racially and socioeconomically diverse pat...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2022-07-01
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| Series: | Lupus Science and Medicine |
| Online Access: | https://lupus.bmj.com/content/9/1/e000720.full |
| _version_ | 1797777958470942720 |
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| author | Ann Rosenthal Shivani Garg Christie Bartels Betty Chewning David Gazeley Shelby Gomez Noah Kaitz Amanda C Weber |
| author_facet | Ann Rosenthal Shivani Garg Christie Bartels Betty Chewning David Gazeley Shelby Gomez Noah Kaitz Amanda C Weber |
| author_sort | Ann Rosenthal |
| collection | DOAJ |
| description | Objective Patients identified as black and from disadvantaged backgrounds have a twofold higher hydroxychloroquine (HCQ) non-adherence, which contributes to worse lupus outcomes and disparities. Yet, most adherence interventions lack tailored strategies for racially and socioeconomically diverse patients who face unique challenges with HCQ. We aimed to examine a broadly representative group of patients with SLE and physician perspectives on HCQ adherence and adherence strategies to redesign an adherence intervention.Methods We conducted four virtual focus groups (90 min each) with 11 racially and socioeconomically diverse patients with SLE recruited from two health systems. Additionally, we hosted two focus group meetings with nine healthcare advisors. In focus groups, patients: (1) shared their perspectives on using HCQ; (2) shared concerns leading to non-adherence; (3) discussed strategies to overcome concerns; (4) prioritised strategies from the most to least valuable to inform an adherence intervention. In two separate focus groups, healthcare advisors gave feedback to optimise an adherence intervention. Using content analysis, we analysed transcripts to redesign our adherence intervention.Results Worry about side effects was the most common barrier phrase mentioned by patients. Key themes among patients’ concerns about HCQ included: information gaps, logistical barriers, misbeliefs and medication burden. Finally, patients suggested adherence strategies and ranked those most valuable including co-pay assistance, personal reminders, etc. Patient and healthcare advisors informed designing a laminate version of an adherence intervention to link each barrier category with four to six patient-recommended adherence strategies.Conclusion We developed a patient stakeholder-informed and healthcare stakeholder-informed tailored intervention that will target non-adherence at the individual patient level. |
| first_indexed | 2024-03-12T23:10:29Z |
| format | Article |
| id | doaj.art-56f8075b669b4985b9062fc85f8d0fa9 |
| institution | Directory Open Access Journal |
| issn | 2053-8790 |
| language | English |
| last_indexed | 2024-03-12T23:10:29Z |
| publishDate | 2022-07-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | Lupus Science and Medicine |
| spelling | doaj.art-56f8075b669b4985b9062fc85f8d0fa92023-07-18T07:00:07ZengBMJ Publishing GroupLupus Science and Medicine2053-87902022-07-019110.1136/lupus-2022-000720Patient and healthcare team recommended medication adherence strategies for hydroxychloroquine: results of a qualitative study informing intervention developmentAnn Rosenthal0Shivani Garg1Christie Bartels2Betty Chewning3David Gazeley4Shelby Gomez5Noah Kaitz6Amanda C Weber7Department of Medicine, Division of Rheumatology, Medical College of Wisconsin, Milwaukee, Wisconsin, USADepartment of Medicine, Division of Rheumatology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USADepartment of Medicine, Division of Rheumatology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USADepartment of Pharmacy, University of Wisconsin-Madison School of Pharmacy, Madison, Wisconsin, USADepartment of Medicine, Rheumatology, Medical College of Wisconsin, Milwaukee, Wisconsin, USADepartment of Pharmacy, University of Wisconsin-Madison School of Pharmacy, Madison, Wisconsin, USADepartment of Pharmacy, University of Wisconsin-Madison School of Pharmacy, Madison, Wisconsin, USADepartment of Medicine, Division of Rheumatology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USAObjective Patients identified as black and from disadvantaged backgrounds have a twofold higher hydroxychloroquine (HCQ) non-adherence, which contributes to worse lupus outcomes and disparities. Yet, most adherence interventions lack tailored strategies for racially and socioeconomically diverse patients who face unique challenges with HCQ. We aimed to examine a broadly representative group of patients with SLE and physician perspectives on HCQ adherence and adherence strategies to redesign an adherence intervention.Methods We conducted four virtual focus groups (90 min each) with 11 racially and socioeconomically diverse patients with SLE recruited from two health systems. Additionally, we hosted two focus group meetings with nine healthcare advisors. In focus groups, patients: (1) shared their perspectives on using HCQ; (2) shared concerns leading to non-adherence; (3) discussed strategies to overcome concerns; (4) prioritised strategies from the most to least valuable to inform an adherence intervention. In two separate focus groups, healthcare advisors gave feedback to optimise an adherence intervention. Using content analysis, we analysed transcripts to redesign our adherence intervention.Results Worry about side effects was the most common barrier phrase mentioned by patients. Key themes among patients’ concerns about HCQ included: information gaps, logistical barriers, misbeliefs and medication burden. Finally, patients suggested adherence strategies and ranked those most valuable including co-pay assistance, personal reminders, etc. Patient and healthcare advisors informed designing a laminate version of an adherence intervention to link each barrier category with four to six patient-recommended adherence strategies.Conclusion We developed a patient stakeholder-informed and healthcare stakeholder-informed tailored intervention that will target non-adherence at the individual patient level.https://lupus.bmj.com/content/9/1/e000720.full |
| spellingShingle | Ann Rosenthal Shivani Garg Christie Bartels Betty Chewning David Gazeley Shelby Gomez Noah Kaitz Amanda C Weber Patient and healthcare team recommended medication adherence strategies for hydroxychloroquine: results of a qualitative study informing intervention development Lupus Science and Medicine |
| title | Patient and healthcare team recommended medication adherence strategies for hydroxychloroquine: results of a qualitative study informing intervention development |
| title_full | Patient and healthcare team recommended medication adherence strategies for hydroxychloroquine: results of a qualitative study informing intervention development |
| title_fullStr | Patient and healthcare team recommended medication adherence strategies for hydroxychloroquine: results of a qualitative study informing intervention development |
| title_full_unstemmed | Patient and healthcare team recommended medication adherence strategies for hydroxychloroquine: results of a qualitative study informing intervention development |
| title_short | Patient and healthcare team recommended medication adherence strategies for hydroxychloroquine: results of a qualitative study informing intervention development |
| title_sort | patient and healthcare team recommended medication adherence strategies for hydroxychloroquine results of a qualitative study informing intervention development |
| url | https://lupus.bmj.com/content/9/1/e000720.full |
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