All-Trans-Retinoic Acid Suppresses Neointimal Hyperplasia and Inhibits Vascular Smooth Muscle Cell Proliferation and Migration via Activation of AMPK Signaling Pathway

All-Trans-Retinoic Acid Suppresses Neointimal Hyperplasia and Inhibits Vascular Smooth Muscle Cell Proliferation and Migration via Activation of AMPK Signaling Pathway

The proliferation and migration of vascular smooth muscle cells (VSMC) is extensively involved in pathogenesis of neointimal hyperplasia. All-trans-retinoic acid (ATRA) is a natural metabolite of vitamin A. Here, we investigated the involvement of AMP-activated protein kinase (AMPK) in the anti-neoi...

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Bibliographic Details
Main Authors: Jingzhi Zhang, Bo Deng, Xiaoli Jiang, Min Cai, Ningning Liu, Shuangwei Zhang, Yongzhen Tan, Guiqiong Huang, Wen Jin, Bin Liu, Shiming Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Pharmacology
Subjects:
all-trans-retinoic acid
neointimal hyperplasia
vascular smooth muscle cell
proliferation
AMP-activated protein kinase
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00485/full

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