Myeloid masquerade: Microglial transcriptional signatures in retinal development and disease
Microglia are dynamic guardians of neural tissue and the resident immune cells of the central nervous system (CNS). The disease-associated microglial signature (DAM), also known as the microglial neurodegenerative phenotype (MGnD), has gained significant attention in recent years as a fundamental mi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2023.1106547/full |
| _version_ | 1828053729108033536 |
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| author | Kristen M. Pitts Kristen M. Pitts Milica A. Margeta Milica A. Margeta |
| author_facet | Kristen M. Pitts Kristen M. Pitts Milica A. Margeta Milica A. Margeta |
| author_sort | Kristen M. Pitts |
| collection | DOAJ |
| description | Microglia are dynamic guardians of neural tissue and the resident immune cells of the central nervous system (CNS). The disease-associated microglial signature (DAM), also known as the microglial neurodegenerative phenotype (MGnD), has gained significant attention in recent years as a fundamental microglial response common to various neurodegenerative disease pathologies. Interestingly, this signature shares many features in common with developmental microglia, suggesting the existence of recycled gene programs which play a role both in early neural circuit formation as well as in response to aging and disease. In addition, recent advances in single cell RNA sequencing have revealed significant heterogeneity within the original DAM signature, with contributions from both yolk sac-derived microglia as well as bone marrow-derived macrophages. In this review, we examine the role of the DAM signature in retinal development and disease, highlighting crosstalk between resident microglia and infiltrating monocytes which may critically contribute to the underlying mechanisms of age-related neurodegeneration. |
| first_indexed | 2024-04-10T20:12:17Z |
| format | Article |
| id | doaj.art-56fb5218939841fb9e0483a9ffeb113d |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-04-10T20:12:17Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-56fb5218939841fb9e0483a9ffeb113d2023-01-26T10:07:38ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022023-01-011710.3389/fncel.2023.11065471106547Myeloid masquerade: Microglial transcriptional signatures in retinal development and diseaseKristen M. Pitts0Kristen M. Pitts1Milica A. Margeta2Milica A. Margeta3Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, United StatesSchepens Eye Research Institute of Mass, Eye and Ear, Boston, MA, United StatesDepartment of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, United StatesSchepens Eye Research Institute of Mass, Eye and Ear, Boston, MA, United StatesMicroglia are dynamic guardians of neural tissue and the resident immune cells of the central nervous system (CNS). The disease-associated microglial signature (DAM), also known as the microglial neurodegenerative phenotype (MGnD), has gained significant attention in recent years as a fundamental microglial response common to various neurodegenerative disease pathologies. Interestingly, this signature shares many features in common with developmental microglia, suggesting the existence of recycled gene programs which play a role both in early neural circuit formation as well as in response to aging and disease. In addition, recent advances in single cell RNA sequencing have revealed significant heterogeneity within the original DAM signature, with contributions from both yolk sac-derived microglia as well as bone marrow-derived macrophages. In this review, we examine the role of the DAM signature in retinal development and disease, highlighting crosstalk between resident microglia and infiltrating monocytes which may critically contribute to the underlying mechanisms of age-related neurodegeneration.https://www.frontiersin.org/articles/10.3389/fncel.2023.1106547/fullmicrogliamonocytesretinaretinal developmentneurodegenerationsingle cell RNA sequencing |
| spellingShingle | Kristen M. Pitts Kristen M. Pitts Milica A. Margeta Milica A. Margeta Myeloid masquerade: Microglial transcriptional signatures in retinal development and disease Frontiers in Cellular Neuroscience microglia monocytes retina retinal development neurodegeneration single cell RNA sequencing |
| title | Myeloid masquerade: Microglial transcriptional signatures in retinal development and disease |
| title_full | Myeloid masquerade: Microglial transcriptional signatures in retinal development and disease |
| title_fullStr | Myeloid masquerade: Microglial transcriptional signatures in retinal development and disease |
| title_full_unstemmed | Myeloid masquerade: Microglial transcriptional signatures in retinal development and disease |
| title_short | Myeloid masquerade: Microglial transcriptional signatures in retinal development and disease |
| title_sort | myeloid masquerade microglial transcriptional signatures in retinal development and disease |
| topic | microglia monocytes retina retinal development neurodegeneration single cell RNA sequencing |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2023.1106547/full |
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