The TNFSF Members APRIL and BAFF and Their Receptors TACI, BCMA, and BAFFR in Oncology, With a Special Focus in Breast Cancer
Tumor necrosis factor (TNF) superfamily consists of 19 ligands and 29 receptors and is related to multiple cellular events from proliferation and differentiation to apoptosis and tumor reduction. In this review, we overview the whole system, and we focus on A proliferation-inducing ligand (APRIL, TN...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-06-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2020.00827/full |
| _version_ | 1823989760767557632 |
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| author | Marilena Kampa George Notas Efstathios N. Stathopoulos Andreas Tsapis Elias Castanas |
| author_facet | Marilena Kampa George Notas Efstathios N. Stathopoulos Andreas Tsapis Elias Castanas |
| author_sort | Marilena Kampa |
| collection | DOAJ |
| description | Tumor necrosis factor (TNF) superfamily consists of 19 ligands and 29 receptors and is related to multiple cellular events from proliferation and differentiation to apoptosis and tumor reduction. In this review, we overview the whole system, and we focus on A proliferation-inducing ligand (APRIL, TNFSF13) and B cell-activating factor (BAFF, TNFSF13B) and their receptors transmembrane activator and Ca2+ modulator (CAML) interactor (TACI, TNFRSF13B), B cell maturation antigen (BCMA, TNFRSF17), and BAFF receptor (BAFFR, TNFRSF13C). We explore their role in cancer and novel biological therapies introduced for multiple myeloma and further focus on breast cancer, in which the modulation of this system seems to be of potential interest, as a novel therapeutic target. Finally, we discuss some precautions which should be taken into consideration, while targeting the APRIL–BAFF system. |
| first_indexed | 2024-12-18T15:31:06Z |
| format | Article |
| id | doaj.art-56fbdacecfeb400d8e54932c72de7ba2 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-18T15:31:06Z |
| publishDate | 2020-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-56fbdacecfeb400d8e54932c72de7ba22022-12-21T21:03:07ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-06-011010.3389/fonc.2020.00827521907The TNFSF Members APRIL and BAFF and Their Receptors TACI, BCMA, and BAFFR in Oncology, With a Special Focus in Breast CancerMarilena Kampa0George Notas1Efstathios N. Stathopoulos2Andreas Tsapis3Elias Castanas4Laboratory of Experimental Endocrinology, School of Medicine, University of Crete, Heraklon, GreeceLaboratory of Experimental Endocrinology, School of Medicine, University of Crete, Heraklon, GreeceLaboratory of Pathology, School of Medicine, University of Crete, Heraklion, GreeceLaboratory of Experimental Endocrinology, School of Medicine, University of Crete, Heraklon, GreeceLaboratory of Experimental Endocrinology, School of Medicine, University of Crete, Heraklon, GreeceTumor necrosis factor (TNF) superfamily consists of 19 ligands and 29 receptors and is related to multiple cellular events from proliferation and differentiation to apoptosis and tumor reduction. In this review, we overview the whole system, and we focus on A proliferation-inducing ligand (APRIL, TNFSF13) and B cell-activating factor (BAFF, TNFSF13B) and their receptors transmembrane activator and Ca2+ modulator (CAML) interactor (TACI, TNFRSF13B), B cell maturation antigen (BCMA, TNFRSF17), and BAFF receptor (BAFFR, TNFRSF13C). We explore their role in cancer and novel biological therapies introduced for multiple myeloma and further focus on breast cancer, in which the modulation of this system seems to be of potential interest, as a novel therapeutic target. Finally, we discuss some precautions which should be taken into consideration, while targeting the APRIL–BAFF system.https://www.frontiersin.org/article/10.3389/fonc.2020.00827/fullAPRIL (TNFSF13)BAFF (TNFSF13B)BCMA (TNFRSF17)TACI (TNFRSF13B)BAFFR (TNFRSF13C)breast cancer |
| spellingShingle | Marilena Kampa George Notas Efstathios N. Stathopoulos Andreas Tsapis Elias Castanas The TNFSF Members APRIL and BAFF and Their Receptors TACI, BCMA, and BAFFR in Oncology, With a Special Focus in Breast Cancer Frontiers in Oncology APRIL (TNFSF13) BAFF (TNFSF13B) BCMA (TNFRSF17) TACI (TNFRSF13B) BAFFR (TNFRSF13C) breast cancer |
| title | The TNFSF Members APRIL and BAFF and Their Receptors TACI, BCMA, and BAFFR in Oncology, With a Special Focus in Breast Cancer |
| title_full | The TNFSF Members APRIL and BAFF and Their Receptors TACI, BCMA, and BAFFR in Oncology, With a Special Focus in Breast Cancer |
| title_fullStr | The TNFSF Members APRIL and BAFF and Their Receptors TACI, BCMA, and BAFFR in Oncology, With a Special Focus in Breast Cancer |
| title_full_unstemmed | The TNFSF Members APRIL and BAFF and Their Receptors TACI, BCMA, and BAFFR in Oncology, With a Special Focus in Breast Cancer |
| title_short | The TNFSF Members APRIL and BAFF and Their Receptors TACI, BCMA, and BAFFR in Oncology, With a Special Focus in Breast Cancer |
| title_sort | tnfsf members april and baff and their receptors taci bcma and baffr in oncology with a special focus in breast cancer |
| topic | APRIL (TNFSF13) BAFF (TNFSF13B) BCMA (TNFRSF17) TACI (TNFRSF13B) BAFFR (TNFRSF13C) breast cancer |
| url | https://www.frontiersin.org/article/10.3389/fonc.2020.00827/full |
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