New Stable Gallium(III) and Indium(III) Complexes with Thiosemicarbazone Ligands: A Biological Evaluation
The aim of this work is to explore a new library of coordination compounds for medicinal applications. Gallium is known for its various applications in this field. Presently, indium is not particularly important in medicine, but it shares a lot of chemical traits with its above-mentioned lighter com...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/29/2/497 |
| _version_ | 1797339538595512320 |
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| author | Lorenzo Verderi Mirco Scaccaglia Martina Rega Cristina Bacci Silvana Pinelli Giorgio Pelosi Franco Bisceglie |
| author_facet | Lorenzo Verderi Mirco Scaccaglia Martina Rega Cristina Bacci Silvana Pinelli Giorgio Pelosi Franco Bisceglie |
| author_sort | Lorenzo Verderi |
| collection | DOAJ |
| description | The aim of this work is to explore a new library of coordination compounds for medicinal applications. Gallium is known for its various applications in this field. Presently, indium is not particularly important in medicine, but it shares a lot of chemical traits with its above-mentioned lighter companion, gallium, and is also used in radio imaging. These metals are combined with thiosemicarbazones, ligating compounds increasingly known for their biological and pharmaceutical applications. In particular, the few ligands chosen to interact with these hard metal ions share the ideal affinity for a high charge density. Therefore, in this work we describe the synthesis and the characterization of the resulting coordination compounds. The yields of the reactions vary from a minimum of 21% to a maximum of 82%, using a fast and easy procedure. Nuclear Magnetic Resonance (NMR) and Infra Red (IR) spectroscopy, mass spectrometry, elemental analysis, and X-ray Diffraction (XRD) confirm the formation of stable compounds in all cases and a ligand-to-metal 2:1 stoichiometry with both cations. In addition, we further investigated their chemical and biological characteristics, via UV-visible titrations, stability tests, and cytotoxicity and antibiotic assays. The results confirm a strong stability in all explored conditions, which suggests that these compounds are more suitable for radio imaging applications rather than for antitumoral or antimicrobic ones. |
| first_indexed | 2024-03-08T09:48:41Z |
| format | Article |
| id | doaj.art-56fbffa68f824a5e91da52e00d3e63f1 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-08T09:48:41Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-56fbffa68f824a5e91da52e00d3e63f12024-01-29T14:09:07ZengMDPI AGMolecules1420-30492024-01-0129249710.3390/molecules29020497New Stable Gallium(III) and Indium(III) Complexes with Thiosemicarbazone Ligands: A Biological EvaluationLorenzo Verderi0Mirco Scaccaglia1Martina Rega2Cristina Bacci3Silvana Pinelli4Giorgio Pelosi5Franco Bisceglie6Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, ItalyDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, ItalyDepartment of Veterinary Science, University of Parma, Strada del Taglio 10, 43126 Parma, ItalyDepartment of Veterinary Science, University of Parma, Strada del Taglio 10, 43126 Parma, ItalyDepartment of Medicine and Surgery, University of Parma, Via Gramsci 14, 43126 Parma, ItalyDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, ItalyDepartment of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, ItalyThe aim of this work is to explore a new library of coordination compounds for medicinal applications. Gallium is known for its various applications in this field. Presently, indium is not particularly important in medicine, but it shares a lot of chemical traits with its above-mentioned lighter companion, gallium, and is also used in radio imaging. These metals are combined with thiosemicarbazones, ligating compounds increasingly known for their biological and pharmaceutical applications. In particular, the few ligands chosen to interact with these hard metal ions share the ideal affinity for a high charge density. Therefore, in this work we describe the synthesis and the characterization of the resulting coordination compounds. The yields of the reactions vary from a minimum of 21% to a maximum of 82%, using a fast and easy procedure. Nuclear Magnetic Resonance (NMR) and Infra Red (IR) spectroscopy, mass spectrometry, elemental analysis, and X-ray Diffraction (XRD) confirm the formation of stable compounds in all cases and a ligand-to-metal 2:1 stoichiometry with both cations. In addition, we further investigated their chemical and biological characteristics, via UV-visible titrations, stability tests, and cytotoxicity and antibiotic assays. The results confirm a strong stability in all explored conditions, which suggests that these compounds are more suitable for radio imaging applications rather than for antitumoral or antimicrobic ones.https://www.mdpi.com/1420-3049/29/2/497thiosemicarbazonegallium(III)indium(III)antitumourantibiotic |
| spellingShingle | Lorenzo Verderi Mirco Scaccaglia Martina Rega Cristina Bacci Silvana Pinelli Giorgio Pelosi Franco Bisceglie New Stable Gallium(III) and Indium(III) Complexes with Thiosemicarbazone Ligands: A Biological Evaluation Molecules thiosemicarbazone gallium(III) indium(III) antitumour antibiotic |
| title | New Stable Gallium(III) and Indium(III) Complexes with Thiosemicarbazone Ligands: A Biological Evaluation |
| title_full | New Stable Gallium(III) and Indium(III) Complexes with Thiosemicarbazone Ligands: A Biological Evaluation |
| title_fullStr | New Stable Gallium(III) and Indium(III) Complexes with Thiosemicarbazone Ligands: A Biological Evaluation |
| title_full_unstemmed | New Stable Gallium(III) and Indium(III) Complexes with Thiosemicarbazone Ligands: A Biological Evaluation |
| title_short | New Stable Gallium(III) and Indium(III) Complexes with Thiosemicarbazone Ligands: A Biological Evaluation |
| title_sort | new stable gallium iii and indium iii complexes with thiosemicarbazone ligands a biological evaluation |
| topic | thiosemicarbazone gallium(III) indium(III) antitumour antibiotic |
| url | https://www.mdpi.com/1420-3049/29/2/497 |
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