Pneumococcal whole-cell and protein-based vaccines: changing the paradigm
Introduction: Epidemiologic evaluations of Streptococcus pneumoniae nasopharyngeal (NP) colonization and pneumococcal disease suggest that newer serotypes in future formulations of pneumococcal conjugate vaccines (PCVs) are needed and there may need to be continued reformulations because there are m...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-12-01
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| Series: | Expert Review of Vaccines |
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| Online Access: | http://dx.doi.org/10.1080/14760584.2017.1393335 |
| _version_ | 1797680414753554432 |
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| author | Michael E. Pichichero |
| author_facet | Michael E. Pichichero |
| author_sort | Michael E. Pichichero |
| collection | DOAJ |
| description | Introduction: Epidemiologic evaluations of Streptococcus pneumoniae nasopharyngeal (NP) colonization and pneumococcal disease suggest that newer serotypes in future formulations of pneumococcal conjugate vaccines (PCVs) are needed and there may need to be continued reformulations because there are many new emerging serotypes expressed by pneumococci. Areas covered: Mechanisms of protection by next-generation whole-cell vaccine (WCV) and/or multi-component pneumococcal purified protein vaccines (PPVs) in development for prevention of pneumococcal infections. Expert commentary: A long-term strategy for prevention of pneumococcal disease will likely include WCV and PPVs. However these vaccines will impact disease pathogenesis in a different manner than PCVs. Prevention of pneumococcal NP colonization should not be expected, nor is it desirable because risks for NP colonization by other replacement organisms into the ecological niche vacated by all pneumococci may have consequences. The expression biology of capsule and surface protein antigens are phase dependent. Therefore, the immune response will be different and the mechanism of protection divergent. WCVs and PPVs may be alternative strategies in low income developing countries to protect against invasive disease and reduce NP carriage load. |
| first_indexed | 2024-03-11T23:29:40Z |
| format | Article |
| id | doaj.art-56fd643e67fa4ed68fef96d67c5475cb |
| institution | Directory Open Access Journal |
| issn | 1476-0584 1744-8395 |
| language | English |
| last_indexed | 2024-03-11T23:29:40Z |
| publishDate | 2017-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Expert Review of Vaccines |
| spelling | doaj.art-56fd643e67fa4ed68fef96d67c5475cb2023-09-20T10:18:02ZengTaylor & Francis GroupExpert Review of Vaccines1476-05841744-83952017-12-0116121181119010.1080/14760584.2017.13933351393335Pneumococcal whole-cell and protein-based vaccines: changing the paradigmMichael E. Pichichero0Rochester General Hospital Research InstituteIntroduction: Epidemiologic evaluations of Streptococcus pneumoniae nasopharyngeal (NP) colonization and pneumococcal disease suggest that newer serotypes in future formulations of pneumococcal conjugate vaccines (PCVs) are needed and there may need to be continued reformulations because there are many new emerging serotypes expressed by pneumococci. Areas covered: Mechanisms of protection by next-generation whole-cell vaccine (WCV) and/or multi-component pneumococcal purified protein vaccines (PPVs) in development for prevention of pneumococcal infections. Expert commentary: A long-term strategy for prevention of pneumococcal disease will likely include WCV and PPVs. However these vaccines will impact disease pathogenesis in a different manner than PCVs. Prevention of pneumococcal NP colonization should not be expected, nor is it desirable because risks for NP colonization by other replacement organisms into the ecological niche vacated by all pneumococci may have consequences. The expression biology of capsule and surface protein antigens are phase dependent. Therefore, the immune response will be different and the mechanism of protection divergent. WCVs and PPVs may be alternative strategies in low income developing countries to protect against invasive disease and reduce NP carriage load.http://dx.doi.org/10.1080/14760584.2017.1393335streptococcus pneumoniaepneumococcal conjugate vaccinespneumococcal whole-cell vaccinepneumococcal protein vaccinesnasopharyngeal colonizationclinical trialpathogenesis |
| spellingShingle | Michael E. Pichichero Pneumococcal whole-cell and protein-based vaccines: changing the paradigm Expert Review of Vaccines streptococcus pneumoniae pneumococcal conjugate vaccines pneumococcal whole-cell vaccine pneumococcal protein vaccines nasopharyngeal colonization clinical trial pathogenesis |
| title | Pneumococcal whole-cell and protein-based vaccines: changing the paradigm |
| title_full | Pneumococcal whole-cell and protein-based vaccines: changing the paradigm |
| title_fullStr | Pneumococcal whole-cell and protein-based vaccines: changing the paradigm |
| title_full_unstemmed | Pneumococcal whole-cell and protein-based vaccines: changing the paradigm |
| title_short | Pneumococcal whole-cell and protein-based vaccines: changing the paradigm |
| title_sort | pneumococcal whole cell and protein based vaccines changing the paradigm |
| topic | streptococcus pneumoniae pneumococcal conjugate vaccines pneumococcal whole-cell vaccine pneumococcal protein vaccines nasopharyngeal colonization clinical trial pathogenesis |
| url | http://dx.doi.org/10.1080/14760584.2017.1393335 |
| work_keys_str_mv | AT michaelepichichero pneumococcalwholecellandproteinbasedvaccineschangingtheparadigm |