Ovarian cancer with intestinal wall invasion and hyperamylasemia: a case report
Numerous studies have suggested a robust association between amylase and ovarian cancer. however, few amylase-producing ovarian cancers have been reported because amylase is a rare product of ovarian cancer. A case of an elderly female patient with an upper abdominal unfitness, intestinal wall along...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1299226/full |
| _version_ | 1797319481689636864 |
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| author | Yu Jie Juan Li Chang-feng Man Yu Fan |
| author_facet | Yu Jie Juan Li Chang-feng Man Yu Fan |
| author_sort | Yu Jie |
| collection | DOAJ |
| description | Numerous studies have suggested a robust association between amylase and ovarian cancer. however, few amylase-producing ovarian cancers have been reported because amylase is a rare product of ovarian cancer. A case of an elderly female patient with an upper abdominal unfitness, intestinal wall along with uterine adnexal invasion, and high serum and urinary amylase is summarized in this article. The patient was initially suspected of having a gastrointestinal tumor. Initial laboratory findings showed markedly significantly raised serum and urinary amylase levels. Imaging showed invasion of the intestinal wall and uterine adnexa, and histology of the specimen taken through the abdominal wall lump and electron colonoscopy showed ovarian cancer. The patient’s blood amylase levels decreased to normal after 4 cycles of neoadjuvant chemotherapy with paclitaxel and carboplatin. Following this, she underwent interval debulking surgery, which included total hysterectomy, bilateral adnexectomy, great omentectomy, appendectomy, resection of pelvic and abdominal lesions, and partial rectal resection. Postoperative pathology and immunohistochemistry staining confirmed a diagnosis of high-grade serous ovarian cancer. This case suggests that in female patients, hyperamylasemia may indicate the presence of ovarian cancer. It is necessary to perform a multisite, multipoint histologic examination to identify the tumor’s origin in patients with multiple sites of invasion. |
| first_indexed | 2024-03-08T04:07:31Z |
| format | Article |
| id | doaj.art-56fdf03ee82e47dc8b33b1eecb33e566 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-08T04:07:31Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-56fdf03ee82e47dc8b33b1eecb33e5662024-02-09T04:33:54ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-02-011410.3389/fonc.2024.12992261299226Ovarian cancer with intestinal wall invasion and hyperamylasemia: a case reportYu JieJuan LiChang-feng ManYu FanNumerous studies have suggested a robust association between amylase and ovarian cancer. however, few amylase-producing ovarian cancers have been reported because amylase is a rare product of ovarian cancer. A case of an elderly female patient with an upper abdominal unfitness, intestinal wall along with uterine adnexal invasion, and high serum and urinary amylase is summarized in this article. The patient was initially suspected of having a gastrointestinal tumor. Initial laboratory findings showed markedly significantly raised serum and urinary amylase levels. Imaging showed invasion of the intestinal wall and uterine adnexa, and histology of the specimen taken through the abdominal wall lump and electron colonoscopy showed ovarian cancer. The patient’s blood amylase levels decreased to normal after 4 cycles of neoadjuvant chemotherapy with paclitaxel and carboplatin. Following this, she underwent interval debulking surgery, which included total hysterectomy, bilateral adnexectomy, great omentectomy, appendectomy, resection of pelvic and abdominal lesions, and partial rectal resection. Postoperative pathology and immunohistochemistry staining confirmed a diagnosis of high-grade serous ovarian cancer. This case suggests that in female patients, hyperamylasemia may indicate the presence of ovarian cancer. It is necessary to perform a multisite, multipoint histologic examination to identify the tumor’s origin in patients with multiple sites of invasion.https://www.frontiersin.org/articles/10.3389/fonc.2024.1299226/fullovarian cancerhyperamylasemianeoplasm metastasisdiagnosiscase reports |
| spellingShingle | Yu Jie Juan Li Chang-feng Man Yu Fan Ovarian cancer with intestinal wall invasion and hyperamylasemia: a case report Frontiers in Oncology ovarian cancer hyperamylasemia neoplasm metastasis diagnosis case reports |
| title | Ovarian cancer with intestinal wall invasion and hyperamylasemia: a case report |
| title_full | Ovarian cancer with intestinal wall invasion and hyperamylasemia: a case report |
| title_fullStr | Ovarian cancer with intestinal wall invasion and hyperamylasemia: a case report |
| title_full_unstemmed | Ovarian cancer with intestinal wall invasion and hyperamylasemia: a case report |
| title_short | Ovarian cancer with intestinal wall invasion and hyperamylasemia: a case report |
| title_sort | ovarian cancer with intestinal wall invasion and hyperamylasemia a case report |
| topic | ovarian cancer hyperamylasemia neoplasm metastasis diagnosis case reports |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1299226/full |
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