Transforming growth factor-beta and the glomerular filtration barrier
The increasing burden of chronic kidney disease worldwide and recent advancements in the understanding of pathologic events leading to kidney injury have opened up new potential avenues for therapies to further diminish progression of kidney disease by targeting the glomerular filtration barrier and...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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The Korean Society of Nephrology
2013-03-01
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| Series: | Kidney Research and Clinical Practice |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211913213000041 |
| _version_ | 1819291182044282880 |
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| author | Ayesha Ghayur Peter J. Margetts |
| author_facet | Ayesha Ghayur Peter J. Margetts |
| author_sort | Ayesha Ghayur |
| collection | DOAJ |
| description | The increasing burden of chronic kidney disease worldwide and recent advancements in the understanding of pathologic events leading to kidney injury have opened up new potential avenues for therapies to further diminish progression of kidney disease by targeting the glomerular filtration barrier and reducing proteinuria. The glomerular filtration barrier is affected by many different metabolic and immune-mediated injuries. Glomerular endothelial cells, the glomerular basement membrane, and podocytes—the three components of the filtration barrier—work together to prevent the loss of protein and at the same time allow passage of water and smaller molecules. Damage to any of the components of the filtration barrier can initiate proteinuria and renal fibrosis. Transforming growth factor-beta (TGF-β) is a pleiotropic cytokine strongly associated with the fibrogenic response. It has a known role in tubulointerstitial fibrosis. In this review we will highlight what is known about TGF-β and how it interacts with the components of glomerular filtration barrier and causes loss of function and proteinuria. |
| first_indexed | 2024-12-24T03:34:34Z |
| format | Article |
| id | doaj.art-56fec9d12d534d62b5eb5d323f512d25 |
| institution | Directory Open Access Journal |
| issn | 2211-9132 |
| language | English |
| last_indexed | 2024-12-24T03:34:34Z |
| publishDate | 2013-03-01 |
| publisher | The Korean Society of Nephrology |
| record_format | Article |
| series | Kidney Research and Clinical Practice |
| spelling | doaj.art-56fec9d12d534d62b5eb5d323f512d252022-12-21T17:17:06ZengThe Korean Society of NephrologyKidney Research and Clinical Practice2211-91322013-03-0132131010.1016/j.krcp.2013.01.003Transforming growth factor-beta and the glomerular filtration barrierAyesha GhayurPeter J. MargettsThe increasing burden of chronic kidney disease worldwide and recent advancements in the understanding of pathologic events leading to kidney injury have opened up new potential avenues for therapies to further diminish progression of kidney disease by targeting the glomerular filtration barrier and reducing proteinuria. The glomerular filtration barrier is affected by many different metabolic and immune-mediated injuries. Glomerular endothelial cells, the glomerular basement membrane, and podocytes—the three components of the filtration barrier—work together to prevent the loss of protein and at the same time allow passage of water and smaller molecules. Damage to any of the components of the filtration barrier can initiate proteinuria and renal fibrosis. Transforming growth factor-beta (TGF-β) is a pleiotropic cytokine strongly associated with the fibrogenic response. It has a known role in tubulointerstitial fibrosis. In this review we will highlight what is known about TGF-β and how it interacts with the components of glomerular filtration barrier and causes loss of function and proteinuria.http://www.sciencedirect.com/science/article/pii/S2211913213000041ProteinuriaPodocyteGlomerular endothelial cellTransforming growth factor betaAngiopoietin |
| spellingShingle | Ayesha Ghayur Peter J. Margetts Transforming growth factor-beta and the glomerular filtration barrier Kidney Research and Clinical Practice Proteinuria Podocyte Glomerular endothelial cell Transforming growth factor beta Angiopoietin |
| title | Transforming growth factor-beta and the glomerular filtration barrier |
| title_full | Transforming growth factor-beta and the glomerular filtration barrier |
| title_fullStr | Transforming growth factor-beta and the glomerular filtration barrier |
| title_full_unstemmed | Transforming growth factor-beta and the glomerular filtration barrier |
| title_short | Transforming growth factor-beta and the glomerular filtration barrier |
| title_sort | transforming growth factor beta and the glomerular filtration barrier |
| topic | Proteinuria Podocyte Glomerular endothelial cell Transforming growth factor beta Angiopoietin |
| url | http://www.sciencedirect.com/science/article/pii/S2211913213000041 |
| work_keys_str_mv | AT ayeshaghayur transforminggrowthfactorbetaandtheglomerularfiltrationbarrier AT peterjmargetts transforminggrowthfactorbetaandtheglomerularfiltrationbarrier |