Engineering the glyoxylate cycle for chemical bioproduction
With growing concerns about environmental issues and sustainable economy, bioproduction of chemicals utilizing microbial cell factories provides an eco-friendly alternative to current petro-based processes. Creating high-performance strains (with high titer, yield, and productivity) through metaboli...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1066651/full |
| _version_ | 1811213346520694784 |
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| author | Peng Yang Wenjing Liu Yanan Chen An-Dong Gong |
| author_facet | Peng Yang Wenjing Liu Yanan Chen An-Dong Gong |
| author_sort | Peng Yang |
| collection | DOAJ |
| description | With growing concerns about environmental issues and sustainable economy, bioproduction of chemicals utilizing microbial cell factories provides an eco-friendly alternative to current petro-based processes. Creating high-performance strains (with high titer, yield, and productivity) through metabolic engineering strategies is critical for cost-competitive production. Commonly, it is inevitable to fine-tuning or rewire the endogenous or heterologous pathways in such processes. As an important pathway involved in the synthesis of many kinds of chemicals, the potential of the glyoxylate cycle in metabolic engineering has been studied extensively these years. Here, we review the metabolic regulation of the glyoxylate cycle and summarize recent achievements in microbial production of chemicals through tuning of the glyoxylate cycle, with a focus on studies implemented in model microorganisms. Also, future prospects for bioproduction of glyoxylate cycle-related chemicals are discussed. |
| first_indexed | 2024-04-12T05:45:18Z |
| format | Article |
| id | doaj.art-5702c8d55c784456ad15d177f3e1f4f8 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-12T05:45:18Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-5702c8d55c784456ad15d177f3e1f4f82022-12-22T03:45:28ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-12-011010.3389/fbioe.2022.10666511066651Engineering the glyoxylate cycle for chemical bioproductionPeng YangWenjing LiuYanan ChenAn-Dong GongWith growing concerns about environmental issues and sustainable economy, bioproduction of chemicals utilizing microbial cell factories provides an eco-friendly alternative to current petro-based processes. Creating high-performance strains (with high titer, yield, and productivity) through metabolic engineering strategies is critical for cost-competitive production. Commonly, it is inevitable to fine-tuning or rewire the endogenous or heterologous pathways in such processes. As an important pathway involved in the synthesis of many kinds of chemicals, the potential of the glyoxylate cycle in metabolic engineering has been studied extensively these years. Here, we review the metabolic regulation of the glyoxylate cycle and summarize recent achievements in microbial production of chemicals through tuning of the glyoxylate cycle, with a focus on studies implemented in model microorganisms. Also, future prospects for bioproduction of glyoxylate cycle-related chemicals are discussed.https://www.frontiersin.org/articles/10.3389/fbioe.2022.1066651/fullglyoxylate cyclemetabolic engineeringbiosynthesisTCA cycleorganic acidsamino acids |
| spellingShingle | Peng Yang Wenjing Liu Yanan Chen An-Dong Gong Engineering the glyoxylate cycle for chemical bioproduction Frontiers in Bioengineering and Biotechnology glyoxylate cycle metabolic engineering biosynthesis TCA cycle organic acids amino acids |
| title | Engineering the glyoxylate cycle for chemical bioproduction |
| title_full | Engineering the glyoxylate cycle for chemical bioproduction |
| title_fullStr | Engineering the glyoxylate cycle for chemical bioproduction |
| title_full_unstemmed | Engineering the glyoxylate cycle for chemical bioproduction |
| title_short | Engineering the glyoxylate cycle for chemical bioproduction |
| title_sort | engineering the glyoxylate cycle for chemical bioproduction |
| topic | glyoxylate cycle metabolic engineering biosynthesis TCA cycle organic acids amino acids |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.1066651/full |
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