Inflammatory markers in world trade center workers with asthma: Associations with post traumatic stress disorder.
<h4>Background</h4>Post-traumatic stress disorders (PTSD) is associated with worse asthma outcomes in individuals exposed to the World Trade Center (WTC) site.<h4>Research question</h4>Do WTC workers with coexisting PTSD and asthma have a specific inflammatory pattern that un...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0297616&type=printable |
| _version_ | 1797279603467747328 |
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| author | Juan P Wisnivesky Nikita Agrawal Jyoti Ankam Adam Gonzalez Alex Federman Steven B Markowitz Janette M Birmingham Paula J Busse |
| author_facet | Juan P Wisnivesky Nikita Agrawal Jyoti Ankam Adam Gonzalez Alex Federman Steven B Markowitz Janette M Birmingham Paula J Busse |
| author_sort | Juan P Wisnivesky |
| collection | DOAJ |
| description | <h4>Background</h4>Post-traumatic stress disorders (PTSD) is associated with worse asthma outcomes in individuals exposed to the World Trade Center (WTC) site.<h4>Research question</h4>Do WTC workers with coexisting PTSD and asthma have a specific inflammatory pattern that underlies the relationship with increased asthma morbidity?<h4>Study design and methods</h4>We collected data on a cohort of WTC workers with asthma recruited from the WTC Health Program. Diagnosis of PTSD was ascertained with a Structured Clinical Interview for DSM-5 (Diagnostic and Statistical Manuel of Mental Disorders) and the severity of PTSD symptoms was assessed with the PTSD Checklist 5. We obtained blood and sputum samples to measure cytokines levels in study participants.<h4>Results</h4>Of the 232 WTC workers with diagnosis of asthma in the study, 75 (32%) had PTSD. PTSD was significantly associated with worse asthma control (p = 0.002) and increased resource utilization (p = 0.0002). There was no significant association (p>0.05) between most blood or sputum cytokines with PTSD diagnosis or PCL-5 scores both in unadjusted and adjusted analyses.<h4>Interpretation</h4>Our results suggest that PTSD is not associated with blood and sputum inflammatory markers in WTC workers with asthma. These findings suggest that other mechanisms likely explain the association between PTSD and asthma control in WTC exposed individuals. |
| first_indexed | 2024-03-07T16:28:31Z |
| format | Article |
| id | doaj.art-5704d6739fab4f13bdbd280939be4a26 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-03-07T16:28:31Z |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-5704d6739fab4f13bdbd280939be4a262024-03-03T12:56:27ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-01192e029761610.1371/journal.pone.0297616Inflammatory markers in world trade center workers with asthma: Associations with post traumatic stress disorder.Juan P WisniveskyNikita AgrawalJyoti AnkamAdam GonzalezAlex FedermanSteven B MarkowitzJanette M BirminghamPaula J Busse<h4>Background</h4>Post-traumatic stress disorders (PTSD) is associated with worse asthma outcomes in individuals exposed to the World Trade Center (WTC) site.<h4>Research question</h4>Do WTC workers with coexisting PTSD and asthma have a specific inflammatory pattern that underlies the relationship with increased asthma morbidity?<h4>Study design and methods</h4>We collected data on a cohort of WTC workers with asthma recruited from the WTC Health Program. Diagnosis of PTSD was ascertained with a Structured Clinical Interview for DSM-5 (Diagnostic and Statistical Manuel of Mental Disorders) and the severity of PTSD symptoms was assessed with the PTSD Checklist 5. We obtained blood and sputum samples to measure cytokines levels in study participants.<h4>Results</h4>Of the 232 WTC workers with diagnosis of asthma in the study, 75 (32%) had PTSD. PTSD was significantly associated with worse asthma control (p = 0.002) and increased resource utilization (p = 0.0002). There was no significant association (p>0.05) between most blood or sputum cytokines with PTSD diagnosis or PCL-5 scores both in unadjusted and adjusted analyses.<h4>Interpretation</h4>Our results suggest that PTSD is not associated with blood and sputum inflammatory markers in WTC workers with asthma. These findings suggest that other mechanisms likely explain the association between PTSD and asthma control in WTC exposed individuals.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0297616&type=printable |
| spellingShingle | Juan P Wisnivesky Nikita Agrawal Jyoti Ankam Adam Gonzalez Alex Federman Steven B Markowitz Janette M Birmingham Paula J Busse Inflammatory markers in world trade center workers with asthma: Associations with post traumatic stress disorder. PLoS ONE |
| title | Inflammatory markers in world trade center workers with asthma: Associations with post traumatic stress disorder. |
| title_full | Inflammatory markers in world trade center workers with asthma: Associations with post traumatic stress disorder. |
| title_fullStr | Inflammatory markers in world trade center workers with asthma: Associations with post traumatic stress disorder. |
| title_full_unstemmed | Inflammatory markers in world trade center workers with asthma: Associations with post traumatic stress disorder. |
| title_short | Inflammatory markers in world trade center workers with asthma: Associations with post traumatic stress disorder. |
| title_sort | inflammatory markers in world trade center workers with asthma associations with post traumatic stress disorder |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0297616&type=printable |
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