Role of Angiotensin-Converting Enzyme (ACE) gene polymorphism and ACE activity in predicting outcome after acute myocardial infarction
Background: The Ace polymorphism had shown association with ACE activity, premature atherosclerosis, myocardial infarction, LV dysfunction, LV remodelling, severity and extent of CAD and mortality after MI. Though ACE I/D polymorphism has been reported to be associated with various cardiovascular di...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-02-01
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| Series: | International Journal of Cardiology: Heart & Vasculature |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352906720303997 |
| _version_ | 1818411608664178688 |
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| author | Nagaraja Moorthy Kalpana Saligrama Ramegowda Simran Jain G. Bharath Archana Sinha Manjunath C. Nanjappa Rita Christopher |
| author_facet | Nagaraja Moorthy Kalpana Saligrama Ramegowda Simran Jain G. Bharath Archana Sinha Manjunath C. Nanjappa Rita Christopher |
| author_sort | Nagaraja Moorthy |
| collection | DOAJ |
| description | Background: The Ace polymorphism had shown association with ACE activity, premature atherosclerosis, myocardial infarction, LV dysfunction, LV remodelling, severity and extent of CAD and mortality after MI. Though ACE I/D polymorphism has been reported to be associated with various cardiovascular diseases it remained a controversial risk factor and studies have presented conflicting results. This study was designed to determine the association between ACE) gene insertion/deletion (I/D) polymorphism, ACE activity and acute STEMI in Indian population and to determine its influence on outcome after acute MI. Materials and methods: We investigated 934 patients diagnosed with acute STEMI who underwent thrombolysis. ACE I/D polymorphism was detected by polymerase chain reaction and ACE activity was measured in 615 patients. Results: The prevalence of DD, ID, and II genotypes in our study group were 41.97%, 34.36%, and 23.66% respectively. The ACE polymorphism was not significantly associated with the type of myocardial infarction, the LV ejection fraction, the number of vessels diseased and patency of the vessel after thrombolysis. The polymorphism had no influence on in hospital mortality (P = 0.453). The ACE activity also showed no influence on in hospital mortality (P = 0.482). The age > 60 years, Male gender, occluded artery and severe LV dysfunction (LVEF < 35%) were predictors of in-hospital mortality on multivariate regression analysis. Conclusion: There was no differences among ACE (I/D) polymorphism observed in STEMI population. Neither ACE I/D polymorphism nor ACE activity predicted in-hospital mortality inpatients admitted with acute STEMI. |
| first_indexed | 2024-12-14T10:34:07Z |
| format | Article |
| id | doaj.art-570551a4f0df4cde8a715fc17ca340e9 |
| institution | Directory Open Access Journal |
| issn | 2352-9067 |
| language | English |
| last_indexed | 2024-12-14T10:34:07Z |
| publishDate | 2021-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj.art-570551a4f0df4cde8a715fc17ca340e92022-12-21T23:06:01ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672021-02-0132100701Role of Angiotensin-Converting Enzyme (ACE) gene polymorphism and ACE activity in predicting outcome after acute myocardial infarctionNagaraja Moorthy0Kalpana Saligrama Ramegowda1Simran Jain2G. Bharath3Archana Sinha4Manjunath C. Nanjappa5Rita Christopher6Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bangalore 560069, India; Corresponding author at: Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bangalore 560069, India.Department of Pathology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bangalore 560069, IndiaDepartment of Pathology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bangalore 560069, IndiaDepartment of Pathology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bangalore 560069, IndiaDepartment of Clinical Nutrition, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, IndiaDepartment of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bangalore 560069, IndiaDepartment of Neurochemistry, National Institute of Mental Health and Neurosciences, Bangalore 560029, IndiaBackground: The Ace polymorphism had shown association with ACE activity, premature atherosclerosis, myocardial infarction, LV dysfunction, LV remodelling, severity and extent of CAD and mortality after MI. Though ACE I/D polymorphism has been reported to be associated with various cardiovascular diseases it remained a controversial risk factor and studies have presented conflicting results. This study was designed to determine the association between ACE) gene insertion/deletion (I/D) polymorphism, ACE activity and acute STEMI in Indian population and to determine its influence on outcome after acute MI. Materials and methods: We investigated 934 patients diagnosed with acute STEMI who underwent thrombolysis. ACE I/D polymorphism was detected by polymerase chain reaction and ACE activity was measured in 615 patients. Results: The prevalence of DD, ID, and II genotypes in our study group were 41.97%, 34.36%, and 23.66% respectively. The ACE polymorphism was not significantly associated with the type of myocardial infarction, the LV ejection fraction, the number of vessels diseased and patency of the vessel after thrombolysis. The polymorphism had no influence on in hospital mortality (P = 0.453). The ACE activity also showed no influence on in hospital mortality (P = 0.482). The age > 60 years, Male gender, occluded artery and severe LV dysfunction (LVEF < 35%) were predictors of in-hospital mortality on multivariate regression analysis. Conclusion: There was no differences among ACE (I/D) polymorphism observed in STEMI population. Neither ACE I/D polymorphism nor ACE activity predicted in-hospital mortality inpatients admitted with acute STEMI.http://www.sciencedirect.com/science/article/pii/S2352906720303997ACE activityACE polymorphismAcute myocardial infarction |
| spellingShingle | Nagaraja Moorthy Kalpana Saligrama Ramegowda Simran Jain G. Bharath Archana Sinha Manjunath C. Nanjappa Rita Christopher Role of Angiotensin-Converting Enzyme (ACE) gene polymorphism and ACE activity in predicting outcome after acute myocardial infarction International Journal of Cardiology: Heart & Vasculature ACE activity ACE polymorphism Acute myocardial infarction |
| title | Role of Angiotensin-Converting Enzyme (ACE) gene polymorphism and ACE activity in predicting outcome after acute myocardial infarction |
| title_full | Role of Angiotensin-Converting Enzyme (ACE) gene polymorphism and ACE activity in predicting outcome after acute myocardial infarction |
| title_fullStr | Role of Angiotensin-Converting Enzyme (ACE) gene polymorphism and ACE activity in predicting outcome after acute myocardial infarction |
| title_full_unstemmed | Role of Angiotensin-Converting Enzyme (ACE) gene polymorphism and ACE activity in predicting outcome after acute myocardial infarction |
| title_short | Role of Angiotensin-Converting Enzyme (ACE) gene polymorphism and ACE activity in predicting outcome after acute myocardial infarction |
| title_sort | role of angiotensin converting enzyme ace gene polymorphism and ace activity in predicting outcome after acute myocardial infarction |
| topic | ACE activity ACE polymorphism Acute myocardial infarction |
| url | http://www.sciencedirect.com/science/article/pii/S2352906720303997 |
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