FEATURES OF REDOX REGULATION IN TUMOR CELLS
Endogenous mechanisms of reactive oxygen (ROS) and nitrogen species production and of antioxidant defense systems in tumor cells are analyzed. Increased ROS production is an important regulator of metabolic changes in these cells: enhanced proliferation, apoptosis inhibition, resistance to hypoxia a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Siberian Branch Publishing House
2019-05-01
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| Series: | Сибирский научный медицинский журнал |
| Subjects: | |
| Online Access: | https://sibmed.elpub.ru/jour/article/view/128 |
| _version_ | 1797269593896517632 |
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| author | N. K. Zenkov P. M. Kozhin A. V. Vcherashnyaya G. G. Martinovich N. V. Kandalintseva E. B. Menshchikova |
| author_facet | N. K. Zenkov P. M. Kozhin A. V. Vcherashnyaya G. G. Martinovich N. V. Kandalintseva E. B. Menshchikova |
| author_sort | N. K. Zenkov |
| collection | DOAJ |
| description | Endogenous mechanisms of reactive oxygen (ROS) and nitrogen species production and of antioxidant defense systems in tumor cells are analyzed. Increased ROS production is an important regulator of metabolic changes in these cells: enhanced proliferation, apoptosis inhibition, resistance to hypoxia and to cytostatics (doxorubicin, carboplatin, cisplatin, etc.). The most active ROS sources in tumor cells are mitochondria, NAD(P)H oxidases and peroxisomes, which synthesize O2 • – and H2O2. In mitochondria, the superoxide anion radical is generated mainly by complexes I and III; membrane NAD(P)H oxidases Nox1, Nox2, Nox3, and Nox5 produce O2 • –, Nox4, and dual oxidases DUOX-1, DUOX-2 – mainly H2O2. Increasing ROS stationary concentration activates endogenous antioxidant defense mechanisms, such as redox-dependent antioxidant respons(iv)e element system Keap1/Nrf2/ARE and autophagy, which allows tumor cells to survive under oxidative stress and may underlie resistance to radio- and chemotherapy. The possibilities of tumor cell redox balance regulation by antioxidants with targeted action and by specific inhibitors of ROS enzymatic production are discussed. |
| first_indexed | 2024-03-08T14:33:53Z |
| format | Article |
| id | doaj.art-57059c42a168468798b406cd20866ae2 |
| institution | Directory Open Access Journal |
| issn | 2410-2512 2410-2520 |
| language | Russian |
| last_indexed | 2024-04-25T01:50:51Z |
| publishDate | 2019-05-01 |
| publisher | Russian Academy of Sciences, Siberian Branch Publishing House |
| record_format | Article |
| series | Сибирский научный медицинский журнал |
| spelling | doaj.art-57059c42a168468798b406cd20866ae22024-03-07T18:49:57ZrusRussian Academy of Sciences, Siberian Branch Publishing HouseСибирский научный медицинский журнал2410-25122410-25202019-05-01392112610.15372/SSMJ20190202121FEATURES OF REDOX REGULATION IN TUMOR CELLSN. K. Zenkov0P. M. Kozhin1A. V. Vcherashnyaya2G. G. Martinovich3N. V. Kandalintseva4E. B. Menshchikova5Research Institute for Experimental and Clinical and Medicine, Federal Research Center for Fundamental and Translational MedicineResearch Institute for Experimental and Clinical and Medicine, Federal Research Center for Fundamental and Translational MedicineBelarusian State UniversityBelarusian State UniversityNovosibirsk State Pedagogical UniversityResearch Institute for Experimental and Clinical and Medicine, Federal Research Center for Fundamental and Translational MedicineEndogenous mechanisms of reactive oxygen (ROS) and nitrogen species production and of antioxidant defense systems in tumor cells are analyzed. Increased ROS production is an important regulator of metabolic changes in these cells: enhanced proliferation, apoptosis inhibition, resistance to hypoxia and to cytostatics (doxorubicin, carboplatin, cisplatin, etc.). The most active ROS sources in tumor cells are mitochondria, NAD(P)H oxidases and peroxisomes, which synthesize O2 • – and H2O2. In mitochondria, the superoxide anion radical is generated mainly by complexes I and III; membrane NAD(P)H oxidases Nox1, Nox2, Nox3, and Nox5 produce O2 • –, Nox4, and dual oxidases DUOX-1, DUOX-2 – mainly H2O2. Increasing ROS stationary concentration activates endogenous antioxidant defense mechanisms, such as redox-dependent antioxidant respons(iv)e element system Keap1/Nrf2/ARE and autophagy, which allows tumor cells to survive under oxidative stress and may underlie resistance to radio- and chemotherapy. The possibilities of tumor cell redox balance regulation by antioxidants with targeted action and by specific inhibitors of ROS enzymatic production are discussed.https://sibmed.elpub.ru/jour/article/view/128reactive oxygen (ros) and nitrogen speciesantioxidantsmitochondrianad(p)h oxidasestumor |
| spellingShingle | N. K. Zenkov P. M. Kozhin A. V. Vcherashnyaya G. G. Martinovich N. V. Kandalintseva E. B. Menshchikova FEATURES OF REDOX REGULATION IN TUMOR CELLS Сибирский научный медицинский журнал reactive oxygen (ros) and nitrogen species antioxidants mitochondria nad(p)h oxidases tumor |
| title | FEATURES OF REDOX REGULATION IN TUMOR CELLS |
| title_full | FEATURES OF REDOX REGULATION IN TUMOR CELLS |
| title_fullStr | FEATURES OF REDOX REGULATION IN TUMOR CELLS |
| title_full_unstemmed | FEATURES OF REDOX REGULATION IN TUMOR CELLS |
| title_short | FEATURES OF REDOX REGULATION IN TUMOR CELLS |
| title_sort | features of redox regulation in tumor cells |
| topic | reactive oxygen (ros) and nitrogen species antioxidants mitochondria nad(p)h oxidases tumor |
| url | https://sibmed.elpub.ru/jour/article/view/128 |
| work_keys_str_mv | AT nkzenkov featuresofredoxregulationintumorcells AT pmkozhin featuresofredoxregulationintumorcells AT avvcherashnyaya featuresofredoxregulationintumorcells AT ggmartinovich featuresofredoxregulationintumorcells AT nvkandalintseva featuresofredoxregulationintumorcells AT ebmenshchikova featuresofredoxregulationintumorcells |