Analyzing and Modeling the Spread of SARS-CoV-2 Omicron Lineages BA.1 and BA.2, France, September 2021–February 2022
We analyzed 324,734 SARS-CoV-2 variant screening tests from France enriched with 16,973 whole-genome sequences sampled during September 1, 2021–February 28, 2022. Results showed the estimated growth advantage of the Omicron variant over the Delta variant to be 105% (95% CI 96%–114%) and that of the...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2022-07-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/28/7/22-0033_article |
| _version_ | 1818253366345596928 |
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| author | Mircea T. Sofonea Bénédicte Roquebert Vincent Foulongne David Morquin Laura Verdurme Sabine Trombert-Paolantoni Mathilde Roussel Jean-Christophe Bonetti Judith Zerah Stéphanie Haim-Boukobza Samuel Alizon |
| author_facet | Mircea T. Sofonea Bénédicte Roquebert Vincent Foulongne David Morquin Laura Verdurme Sabine Trombert-Paolantoni Mathilde Roussel Jean-Christophe Bonetti Judith Zerah Stéphanie Haim-Boukobza Samuel Alizon |
| author_sort | Mircea T. Sofonea |
| collection | DOAJ |
| description |
We analyzed 324,734 SARS-CoV-2 variant screening tests from France enriched with 16,973 whole-genome sequences sampled during September 1, 2021–February 28, 2022. Results showed the estimated growth advantage of the Omicron variant over the Delta variant to be 105% (95% CI 96%–114%) and that of the BA.2 lineage over the BA.1 lineage to be 49% (95% CI 44%–52%). Quantitative PCR cycle threshold values were consistent with an increased ability of Omicron to generate breakthrough infections. Epidemiologic modeling shows that, in spite of its decreased virulence, the Omicron variant can generate important critical COVID-19 activity in hospitals in France. The magnitude of the BA.2 wave in hospitals depends on the level of relaxing of control measures but remains lower than that of BA.1 in median scenarios.
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| first_indexed | 2024-12-12T16:38:56Z |
| format | Article |
| id | doaj.art-57083e0be1db4e1ea5d11f536b1fd2b2 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-12T16:38:56Z |
| publishDate | 2022-07-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-57083e0be1db4e1ea5d11f536b1fd2b22022-12-22T00:18:36ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592022-07-012871355136510.3201/eid2807.220033Analyzing and Modeling the Spread of SARS-CoV-2 Omicron Lineages BA.1 and BA.2, France, September 2021–February 2022Mircea T. SofoneaBénédicte RoquebertVincent FoulongneDavid MorquinLaura VerdurmeSabine Trombert-PaolantoniMathilde RousselJean-Christophe BonettiJudith ZerahStéphanie Haim-BoukobzaSamuel Alizon We analyzed 324,734 SARS-CoV-2 variant screening tests from France enriched with 16,973 whole-genome sequences sampled during September 1, 2021–February 28, 2022. Results showed the estimated growth advantage of the Omicron variant over the Delta variant to be 105% (95% CI 96%–114%) and that of the BA.2 lineage over the BA.1 lineage to be 49% (95% CI 44%–52%). Quantitative PCR cycle threshold values were consistent with an increased ability of Omicron to generate breakthrough infections. Epidemiologic modeling shows that, in spite of its decreased virulence, the Omicron variant can generate important critical COVID-19 activity in hospitals in France. The magnitude of the BA.2 wave in hospitals depends on the level of relaxing of control measures but remains lower than that of BA.1 in median scenarios. https://wwwnc.cdc.gov/eid/article/28/7/22-0033_articleCOVID-19coronavirus diseaseSARS-CoV-2severe acute respiratory syndrome coronavirus 2virusesrespiratory infections |
| spellingShingle | Mircea T. Sofonea Bénédicte Roquebert Vincent Foulongne David Morquin Laura Verdurme Sabine Trombert-Paolantoni Mathilde Roussel Jean-Christophe Bonetti Judith Zerah Stéphanie Haim-Boukobza Samuel Alizon Analyzing and Modeling the Spread of SARS-CoV-2 Omicron Lineages BA.1 and BA.2, France, September 2021–February 2022 Emerging Infectious Diseases COVID-19 coronavirus disease SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 viruses respiratory infections |
| title | Analyzing and Modeling the Spread of SARS-CoV-2 Omicron Lineages BA.1 and BA.2, France, September 2021–February 2022 |
| title_full | Analyzing and Modeling the Spread of SARS-CoV-2 Omicron Lineages BA.1 and BA.2, France, September 2021–February 2022 |
| title_fullStr | Analyzing and Modeling the Spread of SARS-CoV-2 Omicron Lineages BA.1 and BA.2, France, September 2021–February 2022 |
| title_full_unstemmed | Analyzing and Modeling the Spread of SARS-CoV-2 Omicron Lineages BA.1 and BA.2, France, September 2021–February 2022 |
| title_short | Analyzing and Modeling the Spread of SARS-CoV-2 Omicron Lineages BA.1 and BA.2, France, September 2021–February 2022 |
| title_sort | analyzing and modeling the spread of sars cov 2 omicron lineages ba 1 and ba 2 france september 2021 february 2022 |
| topic | COVID-19 coronavirus disease SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 viruses respiratory infections |
| url | https://wwwnc.cdc.gov/eid/article/28/7/22-0033_article |
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