Prolongation of enoxaparin therapy to one month promotes recanalization of occlusively thrombosed deep veins
Aim. To compare effects of prolongation of the treatment with therapeutic doses of enoxaparin to 1 month on recanalization of occlusively thrombosed deep veins (OTDV) of the limbs with results of standard therapy with unfractionated heparin (UFH). Both treatments were followed by warfarin administra...
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
"Consilium Medicum" Publishing house
2011-08-01
|
| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/30885 |
| _version_ | 1818308353863974912 |
|---|---|
| author | Natal'ya Mikhaylovna Vorob'eva Elizaveta Pavlovna Panchenko Ol'ga Vladimirovna Ermolina Tat'yana Valentinovna Balakhonova Anatoliy Borisovich Dobrovol'skiy Elena Vladimirovna Titaeva Zukhra Bilyalovna Khasanova Anton Yuvenal'evich Postnov Aleksandr Ivanovich Kirienko N M Vorobyeva E P Panchenko O V Ermolina T V Balakhonova A B Dobrovolsky E V Titaeva Z B Khasanova A Yu Postnov A I Kirienko |
| author_facet | Natal'ya Mikhaylovna Vorob'eva Elizaveta Pavlovna Panchenko Ol'ga Vladimirovna Ermolina Tat'yana Valentinovna Balakhonova Anatoliy Borisovich Dobrovol'skiy Elena Vladimirovna Titaeva Zukhra Bilyalovna Khasanova Anton Yuvenal'evich Postnov Aleksandr Ivanovich Kirienko N M Vorobyeva E P Panchenko O V Ermolina T V Balakhonova A B Dobrovolsky E V Titaeva Z B Khasanova A Yu Postnov A I Kirienko |
| author_sort | Natal'ya Mikhaylovna Vorob'eva |
| collection | DOAJ |
| description | Aim. To compare effects of prolongation of the treatment with therapeutic doses of enoxaparin to 1 month on recanalization of occlusively thrombosed deep veins (OTDV) of the limbs with results of standard therapy with unfractionated heparin (UFH). Both treatments were followed by warfarin administration.
Material and methods. Thirty patients were selected from 111 patients with a history of deep vein thrombosis (DVT) and/or pulmonary artery embolism according to the following criteria: the presence of occlusive thrombosis of one deep vein minimum; the absence of DVT for 12 months of follow-up. Patients of group 1 (n = 15) received standard therapy (UFH for at least 5 days) with switch to warfarin. Patients of group 2 (n = 15) received therapeutic doses of enoxaparin (1 mg/kg each 12 hours) for 30 days minimum with switch to warfarin. Follow-up was 12 months. Ultrasonic duplex angioscanning of the limbs was made at baseline, 1, 3, 6 and 12 months after treatment start.
Results. After follow-up month 1, 3 and 6 number of patients with occlusive DVT was significantly less in group 2. All the patients given enoxaparin achieved recanalization of OTDV within 3 months of treatment. OTDV recanalization was not achieved in 20% patients of group 1 even 12 months after treatment start.
Conclusion. Prolongation of enoxaparin treatment to 1 month followed by warfarin treatment is superior to standard UFH treatment followed by warfarin in providing recanalization of OTDV within 3 months of treatment. Moreover, this treatment predicts persistence of recanalization within 12 months of anticoagulant therapy. |
| first_indexed | 2024-12-13T07:12:56Z |
| format | Article |
| id | doaj.art-570a90d41078436788aaaf25a2695082 |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-13T07:12:56Z |
| publishDate | 2011-08-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-570a90d41078436788aaaf25a26950822022-12-21T23:55:37Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422011-08-01838333727901Prolongation of enoxaparin therapy to one month promotes recanalization of occlusively thrombosed deep veinsNatal'ya Mikhaylovna Vorob'evaElizaveta Pavlovna PanchenkoOl'ga Vladimirovna ErmolinaTat'yana Valentinovna BalakhonovaAnatoliy Borisovich Dobrovol'skiyElena Vladimirovna TitaevaZukhra Bilyalovna KhasanovaAnton Yuvenal'evich PostnovAleksandr Ivanovich KirienkoN M Vorobyeva0E P Panchenko1O V Ermolina2T V Balakhonova3A B Dobrovolsky4E V Titaeva5Z B Khasanova6A Yu Postnov7A I Kirienko8Russian Cardiological Research Center, MoscowRussian Cardiological Research Center, MoscowRussian Cardiological Research Center, MoscowRussian Cardiological Research Center, MoscowRussian Cardiological Research Center, MoscowRussian Cardiological Research Center, MoscowRussian Cardiological Research Center, MoscowRussian Cardiological Research Center, MoscowN.I. Pirogov Russian State Medical University, MoscowAim. To compare effects of prolongation of the treatment with therapeutic doses of enoxaparin to 1 month on recanalization of occlusively thrombosed deep veins (OTDV) of the limbs with results of standard therapy with unfractionated heparin (UFH). Both treatments were followed by warfarin administration. Material and methods. Thirty patients were selected from 111 patients with a history of deep vein thrombosis (DVT) and/or pulmonary artery embolism according to the following criteria: the presence of occlusive thrombosis of one deep vein minimum; the absence of DVT for 12 months of follow-up. Patients of group 1 (n = 15) received standard therapy (UFH for at least 5 days) with switch to warfarin. Patients of group 2 (n = 15) received therapeutic doses of enoxaparin (1 mg/kg each 12 hours) for 30 days minimum with switch to warfarin. Follow-up was 12 months. Ultrasonic duplex angioscanning of the limbs was made at baseline, 1, 3, 6 and 12 months after treatment start. Results. After follow-up month 1, 3 and 6 number of patients with occlusive DVT was significantly less in group 2. All the patients given enoxaparin achieved recanalization of OTDV within 3 months of treatment. OTDV recanalization was not achieved in 20% patients of group 1 even 12 months after treatment start. Conclusion. Prolongation of enoxaparin treatment to 1 month followed by warfarin treatment is superior to standard UFH treatment followed by warfarin in providing recanalization of OTDV within 3 months of treatment. Moreover, this treatment predicts persistence of recanalization within 12 months of anticoagulant therapy.https://ter-arkhiv.ru/0040-3660/article/view/30885enoxaparinunfractionated heparinwarfarinocclusive thrombosisrecanalization |
| spellingShingle | Natal'ya Mikhaylovna Vorob'eva Elizaveta Pavlovna Panchenko Ol'ga Vladimirovna Ermolina Tat'yana Valentinovna Balakhonova Anatoliy Borisovich Dobrovol'skiy Elena Vladimirovna Titaeva Zukhra Bilyalovna Khasanova Anton Yuvenal'evich Postnov Aleksandr Ivanovich Kirienko N M Vorobyeva E P Panchenko O V Ermolina T V Balakhonova A B Dobrovolsky E V Titaeva Z B Khasanova A Yu Postnov A I Kirienko Prolongation of enoxaparin therapy to one month promotes recanalization of occlusively thrombosed deep veins Терапевтический архив enoxaparin unfractionated heparin warfarin occlusive thrombosis recanalization |
| title | Prolongation of enoxaparin therapy to one month promotes recanalization of occlusively thrombosed deep veins |
| title_full | Prolongation of enoxaparin therapy to one month promotes recanalization of occlusively thrombosed deep veins |
| title_fullStr | Prolongation of enoxaparin therapy to one month promotes recanalization of occlusively thrombosed deep veins |
| title_full_unstemmed | Prolongation of enoxaparin therapy to one month promotes recanalization of occlusively thrombosed deep veins |
| title_short | Prolongation of enoxaparin therapy to one month promotes recanalization of occlusively thrombosed deep veins |
| title_sort | prolongation of enoxaparin therapy to one month promotes recanalization of occlusively thrombosed deep veins |
| topic | enoxaparin unfractionated heparin warfarin occlusive thrombosis recanalization |
| url | https://ter-arkhiv.ru/0040-3660/article/view/30885 |
| work_keys_str_mv | AT natalyamikhaylovnavorobeva prolongationofenoxaparintherapytoonemonthpromotesrecanalizationofocclusivelythromboseddeepveins AT elizavetapavlovnapanchenko prolongationofenoxaparintherapytoonemonthpromotesrecanalizationofocclusivelythromboseddeepveins AT olgavladimirovnaermolina prolongationofenoxaparintherapytoonemonthpromotesrecanalizationofocclusivelythromboseddeepveins AT tatyanavalentinovnabalakhonova prolongationofenoxaparintherapytoonemonthpromotesrecanalizationofocclusivelythromboseddeepveins AT anatoliyborisovichdobrovolskiy prolongationofenoxaparintherapytoonemonthpromotesrecanalizationofocclusivelythromboseddeepveins AT elenavladimirovnatitaeva prolongationofenoxaparintherapytoonemonthpromotesrecanalizationofocclusivelythromboseddeepveins AT zukhrabilyalovnakhasanova prolongationofenoxaparintherapytoonemonthpromotesrecanalizationofocclusivelythromboseddeepveins AT antonyuvenalevichpostnov prolongationofenoxaparintherapytoonemonthpromotesrecanalizationofocclusivelythromboseddeepveins AT aleksandrivanovichkirienko prolongationofenoxaparintherapytoonemonthpromotesrecanalizationofocclusivelythromboseddeepveins AT nmvorobyeva prolongationofenoxaparintherapytoonemonthpromotesrecanalizationofocclusivelythromboseddeepveins AT eppanchenko prolongationofenoxaparintherapytoonemonthpromotesrecanalizationofocclusivelythromboseddeepveins AT overmolina prolongationofenoxaparintherapytoonemonthpromotesrecanalizationofocclusivelythromboseddeepveins AT tvbalakhonova prolongationofenoxaparintherapytoonemonthpromotesrecanalizationofocclusivelythromboseddeepveins AT abdobrovolsky prolongationofenoxaparintherapytoonemonthpromotesrecanalizationofocclusivelythromboseddeepveins AT evtitaeva prolongationofenoxaparintherapytoonemonthpromotesrecanalizationofocclusivelythromboseddeepveins AT zbkhasanova prolongationofenoxaparintherapytoonemonthpromotesrecanalizationofocclusivelythromboseddeepveins AT ayupostnov prolongationofenoxaparintherapytoonemonthpromotesrecanalizationofocclusivelythromboseddeepveins AT aikirienko prolongationofenoxaparintherapytoonemonthpromotesrecanalizationofocclusivelythromboseddeepveins |