Gefitinib-loaded DSPE-PEG2000 nanomicelles with CD133 aptamers target lung cancer stem cells

Gefitinib-loaded DSPE-PEG2000 nanomicelles with CD133 aptamers target lung cancer stem cells

Abstract Background Lung cancer stem cells (CSCs) are considered to be the seed of lung cancer, and CD133 is a marker of lung CSCs. Here, we developed gefitinib-loaded poly(ethylene glycol) 2000-distearoylphosphatidylethanolamine nanomicelles with CD133 aptamers (M-Gef-CD133) to eliminate CD133+ lun...

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Bibliographic Details
Main Authors: Xiaolong Huang, Jingsong Huang, Dewen Leng, Shuo Yang, Qi Yao, Jin Sun, Jun Hu
Format: Article
Language:English
Published: BMC 2017-08-01
Series:World Journal of Surgical Oncology
Subjects:
Nanomicelles
Lung cancer
Gefitinib
Cancer stem cells
CD133
Online Access:http://link.springer.com/article/10.1186/s12957-017-1230-4

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