New var reconstruction algorithm exposes high var sequence diversity in a single geographic location in Mali
Abstract Background Encoded by the var gene family, highly variable Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1) proteins mediate tissue-specific cytoadherence of infected erythrocytes, resulting in immune evasion and severe malaria disease. Sequencing and assembling the 40–60 var g...
Main Authors: | Antoine Dara, Elliott F. Drábek, Mark A. Travassos, Kara A. Moser, Arthur L. Delcher, Qi Su, Timothy Hostelley, Drissa Coulibaly, Modibo Daou, Ahmadou Dembele, Issa Diarra, Abdoulaye K. Kone, Bourema Kouriba, Matthew B. Laurens, Amadou Niangaly, Karim Traore, Youssouf Tolo, Claire M. Fraser, Mahamadou A. Thera, Abdoulaye A. Djimde, Ogobara K. Doumbo, Christopher V. Plowe, Joana C. Silva |
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Format: | Article |
Language: | English |
Published: |
BMC
2017-03-01
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Series: | Genome Medicine |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13073-017-0422-4 |
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