Research progress of LINE-1 in the diagnosis, prognosis, and treatment of gynecologic tumors
The retrotransposon known as long interspersed nuclear element-1 (LINE-1), which is currently the sole autonomously mobile transposon in the human genome, can result in insertional mutations, chromosomal rearrangements, and genomic instability. In recent years, numerous studies have shown that LINE-...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1201568/full |
| _version_ | 1797776261313986560 |
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| author | Jiaojiao Fu Jiaojiao Fu Tiansheng Qin Tiansheng Qin Tiansheng Qin Tiansheng Qin Chaoming Li Jiaojiao Zhu Jiaojiao Zhu Yaoyao Ding Yaoyao Ding Meiying Zhou Qing Yang Qing Yang Xiaofeng Liu Xiaofeng Liu Juanhong Zhou Juanhong Zhou Fan Chen Fan Chen |
| author_facet | Jiaojiao Fu Jiaojiao Fu Tiansheng Qin Tiansheng Qin Tiansheng Qin Tiansheng Qin Chaoming Li Jiaojiao Zhu Jiaojiao Zhu Yaoyao Ding Yaoyao Ding Meiying Zhou Qing Yang Qing Yang Xiaofeng Liu Xiaofeng Liu Juanhong Zhou Juanhong Zhou Fan Chen Fan Chen |
| author_sort | Jiaojiao Fu |
| collection | DOAJ |
| description | The retrotransposon known as long interspersed nuclear element-1 (LINE-1), which is currently the sole autonomously mobile transposon in the human genome, can result in insertional mutations, chromosomal rearrangements, and genomic instability. In recent years, numerous studies have shown that LINE-1 is involved in the development of various diseases and also plays an important role in the immune regulation of the organism. The expression of LINE-1 in gynecologic tumors suggests that it is expected to be an independent indicator for early diagnosis and prognosis, and also, as a therapeutic target, LINE-1 is closely associated with gynecologic tumor prognosis. This article discusses the function of LINE-1 in the diagnosis, treatment, and prognosis of ovarian, cervical, and endometrial malignancies, as well as other gynecologic malignancies. It offers fresh perspectives on the early detection of tumors and the creation of novel anti-tumor medications. |
| first_indexed | 2024-03-12T22:47:05Z |
| format | Article |
| id | doaj.art-570b429ed0894bdf81292de9969ef423 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-12T22:47:05Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-570b429ed0894bdf81292de9969ef4232023-07-21T03:47:22ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-07-011310.3389/fonc.2023.12015681201568Research progress of LINE-1 in the diagnosis, prognosis, and treatment of gynecologic tumorsJiaojiao Fu0Jiaojiao Fu1Tiansheng Qin2Tiansheng Qin3Tiansheng Qin4Tiansheng Qin5Chaoming Li6Jiaojiao Zhu7Jiaojiao Zhu8Yaoyao Ding9Yaoyao Ding10Meiying Zhou11Qing Yang12Qing Yang13Xiaofeng Liu14Xiaofeng Liu15Juanhong Zhou16Juanhong Zhou17Fan Chen18Fan Chen19The First Clinical Medical College of Gansu University of Chinese Medicine, Gansu Provincial Hospital, Lanzhou, ChinaDepartment of Obstetrics and Gynecology, Gansu Provincial Hospital, Lanzhou, Gansu, ChinaThe First Clinical Medical College of Gansu University of Chinese Medicine, Gansu Provincial Hospital, Lanzhou, ChinaDepartment of Obstetrics and Gynecology, Gansu Provincial Hospital, Lanzhou, Gansu, ChinaThe First Clinical Medical School, Lanzhou University, Lanzhou, Gansu, ChinaNational Health Commission (NHC) Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor, Gansu Provincial Hospital, Lanzhou, Gansu, ChinaThe First People’s Hospital of Longnan, Longnan City Hospital, Longnan, Gansu, ChinaThe First Clinical Medical College of Gansu University of Chinese Medicine, Gansu Provincial Hospital, Lanzhou, ChinaDepartment of Obstetrics and Gynecology, Gansu Provincial Hospital, Lanzhou, Gansu, ChinaThe First Clinical Medical College of Gansu University of Chinese Medicine, Gansu Provincial Hospital, Lanzhou, ChinaDepartment of Obstetrics and Gynecology, Gansu Provincial Hospital, Lanzhou, Gansu, ChinaDepartment of Obstetrics and Gynecology, Gansu Provincial Hospital, Lanzhou, Gansu, ChinaThe First Clinical Medical College of Gansu University of Chinese Medicine, Gansu Provincial Hospital, Lanzhou, ChinaDepartment of Obstetrics and Gynecology, Gansu Provincial Hospital, Lanzhou, Gansu, ChinaThe First Clinical Medical College of Gansu University of Chinese Medicine, Gansu Provincial Hospital, Lanzhou, ChinaDepartment of Obstetrics and Gynecology, Gansu Provincial Hospital, Lanzhou, Gansu, ChinaThe First Clinical Medical College of Gansu University of Chinese Medicine, Gansu Provincial Hospital, Lanzhou, ChinaDepartment of Obstetrics and Gynecology, Gansu Provincial Hospital, Lanzhou, Gansu, ChinaThe First Clinical Medical College of Gansu University of Chinese Medicine, Gansu Provincial Hospital, Lanzhou, ChinaDepartment of Obstetrics and Gynecology, Gansu Provincial Hospital, Lanzhou, Gansu, ChinaThe retrotransposon known as long interspersed nuclear element-1 (LINE-1), which is currently the sole autonomously mobile transposon in the human genome, can result in insertional mutations, chromosomal rearrangements, and genomic instability. In recent years, numerous studies have shown that LINE-1 is involved in the development of various diseases and also plays an important role in the immune regulation of the organism. The expression of LINE-1 in gynecologic tumors suggests that it is expected to be an independent indicator for early diagnosis and prognosis, and also, as a therapeutic target, LINE-1 is closely associated with gynecologic tumor prognosis. This article discusses the function of LINE-1 in the diagnosis, treatment, and prognosis of ovarian, cervical, and endometrial malignancies, as well as other gynecologic malignancies. It offers fresh perspectives on the early detection of tumors and the creation of novel anti-tumor medications.https://www.frontiersin.org/articles/10.3389/fonc.2023.1201568/fullgynecologic cancersretrotransposonsdiagnostictherapyprognosis |
| spellingShingle | Jiaojiao Fu Jiaojiao Fu Tiansheng Qin Tiansheng Qin Tiansheng Qin Tiansheng Qin Chaoming Li Jiaojiao Zhu Jiaojiao Zhu Yaoyao Ding Yaoyao Ding Meiying Zhou Qing Yang Qing Yang Xiaofeng Liu Xiaofeng Liu Juanhong Zhou Juanhong Zhou Fan Chen Fan Chen Research progress of LINE-1 in the diagnosis, prognosis, and treatment of gynecologic tumors Frontiers in Oncology gynecologic cancers retrotransposons diagnostic therapy prognosis |
| title | Research progress of LINE-1 in the diagnosis, prognosis, and treatment of gynecologic tumors |
| title_full | Research progress of LINE-1 in the diagnosis, prognosis, and treatment of gynecologic tumors |
| title_fullStr | Research progress of LINE-1 in the diagnosis, prognosis, and treatment of gynecologic tumors |
| title_full_unstemmed | Research progress of LINE-1 in the diagnosis, prognosis, and treatment of gynecologic tumors |
| title_short | Research progress of LINE-1 in the diagnosis, prognosis, and treatment of gynecologic tumors |
| title_sort | research progress of line 1 in the diagnosis prognosis and treatment of gynecologic tumors |
| topic | gynecologic cancers retrotransposons diagnostic therapy prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1201568/full |
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