Primary Squamous Cell Carcinoma of Colon and Rectum: A Systematic Review of the Literature
Background - Objective: Primary colorectal squamous cell carcinoma is an extremely rare neoplasm with an incidence of 0.1 to 0.25 per 1,000 diagnosed colorectal carcinomas.The objective of this study was to evaluate its biological behavior and highlight the role of a surgical approach for its manage...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-01-01
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| Series: | Journal of Investigative Surgery |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/08941939.2020.1824044 |
| _version_ | 1797684537057083392 |
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| author | Dimitrios Schizas Ioannis Katsaros Aikaterini Mastoraki Nina-Rafailia Karela Despoina Zampetaki Ioannis I. Lazaridis Dimitrios Tsapralis George E. Theodoropoulos |
| author_facet | Dimitrios Schizas Ioannis Katsaros Aikaterini Mastoraki Nina-Rafailia Karela Despoina Zampetaki Ioannis I. Lazaridis Dimitrios Tsapralis George E. Theodoropoulos |
| author_sort | Dimitrios Schizas |
| collection | DOAJ |
| description | Background - Objective: Primary colorectal squamous cell carcinoma is an extremely rare neoplasm with an incidence of 0.1 to 0.25 per 1,000 diagnosed colorectal carcinomas.The objective of this study was to evaluate its biological behavior and highlight the role of a surgical approach for its management. Methods PubMed and Cohrane databases were independently searched (last search: April 10th, 2020) for articles concerning colorectal squamous cell carcinoma in adult population. Results: Seventy-one studies met predefined inclusion criteria and involved 99 patients (54.5% females) with an age of 56.98 ± 12.19 years (mean ± SD). The most frequent site of occurrence was the rectum (63.5%). Open surgery was conducted at 95% of patients, while 21.4% and 30.3% received neoadjuvant and adjuvant therapy respectively.Postoperative complications were developed in 31.3% of patients, while 6.1% died withing the first month following operation. Five-years survival rate was 49.5% (95% CI: 33.7%-63.4%). Female sex (HR: 0.24; 95% CI: 0.11–0.54; p-value: 0.001) and presence of postoperative complications (HR: 4.10; 95%CI: 1.47–1.46; p-value: 0.007) significantly affected the survival. Conclusions Colorectal Squamous Cell Carcinoma is a rare tumor with an aggressive behavior. Surgery is the standard of treatment for the colontumors, while the role of chemoradiotherapy is promising especially for rectal tumors. Further clinical trials are necessary to determine the preferred treatment approach. |
| first_indexed | 2024-03-12T00:31:09Z |
| format | Article |
| id | doaj.art-570d7a7c567e47aba0395c213384a0a1 |
| institution | Directory Open Access Journal |
| issn | 0894-1939 1521-0553 |
| language | English |
| last_indexed | 2024-03-12T00:31:09Z |
| publishDate | 2022-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Investigative Surgery |
| spelling | doaj.art-570d7a7c567e47aba0395c213384a0a12023-09-15T10:21:26ZengTaylor & Francis GroupJournal of Investigative Surgery0894-19391521-05532022-01-0135115115610.1080/08941939.2020.18240441824044Primary Squamous Cell Carcinoma of Colon and Rectum: A Systematic Review of the LiteratureDimitrios Schizas0Ioannis Katsaros1Aikaterini Mastoraki2Nina-Rafailia Karela3Despoina Zampetaki4Ioannis I. Lazaridis5Dimitrios Tsapralis6George E. Theodoropoulos7First Department of Surgery, National and Kapodistrian University of Athens, Laikon General HospitalFirst Department of Surgery, National and Kapodistrian University of Athens, Laikon General HospitalFirst Department of Surgery, National and Kapodistrian University of Athens, Laikon General HospitalFirst Department of Surgery, National and Kapodistrian University of Athens, Laikon General HospitalFirst Department of Surgery, National and Kapodistrian University of Athens, Laikon General HospitalDepartment of Abdominal Surgery, Clarunis, University Center for Gastrointestinal and Liver DiseasesSurgical Department, General Hospital of IerapetraFirst Department of Propaedeutic Surgery, National and Kapodistrian University of Athens, Hippocration HospitalBackground - Objective: Primary colorectal squamous cell carcinoma is an extremely rare neoplasm with an incidence of 0.1 to 0.25 per 1,000 diagnosed colorectal carcinomas.The objective of this study was to evaluate its biological behavior and highlight the role of a surgical approach for its management. Methods PubMed and Cohrane databases were independently searched (last search: April 10th, 2020) for articles concerning colorectal squamous cell carcinoma in adult population. Results: Seventy-one studies met predefined inclusion criteria and involved 99 patients (54.5% females) with an age of 56.98 ± 12.19 years (mean ± SD). The most frequent site of occurrence was the rectum (63.5%). Open surgery was conducted at 95% of patients, while 21.4% and 30.3% received neoadjuvant and adjuvant therapy respectively.Postoperative complications were developed in 31.3% of patients, while 6.1% died withing the first month following operation. Five-years survival rate was 49.5% (95% CI: 33.7%-63.4%). Female sex (HR: 0.24; 95% CI: 0.11–0.54; p-value: 0.001) and presence of postoperative complications (HR: 4.10; 95%CI: 1.47–1.46; p-value: 0.007) significantly affected the survival. Conclusions Colorectal Squamous Cell Carcinoma is a rare tumor with an aggressive behavior. Surgery is the standard of treatment for the colontumors, while the role of chemoradiotherapy is promising especially for rectal tumors. Further clinical trials are necessary to determine the preferred treatment approach.http://dx.doi.org/10.1080/08941939.2020.1824044squamous cell carcinomalarge intestinecolonrectumrare neoplasms |
| spellingShingle | Dimitrios Schizas Ioannis Katsaros Aikaterini Mastoraki Nina-Rafailia Karela Despoina Zampetaki Ioannis I. Lazaridis Dimitrios Tsapralis George E. Theodoropoulos Primary Squamous Cell Carcinoma of Colon and Rectum: A Systematic Review of the Literature Journal of Investigative Surgery squamous cell carcinoma large intestine colon rectum rare neoplasms |
| title | Primary Squamous Cell Carcinoma of Colon and Rectum: A Systematic Review of the Literature |
| title_full | Primary Squamous Cell Carcinoma of Colon and Rectum: A Systematic Review of the Literature |
| title_fullStr | Primary Squamous Cell Carcinoma of Colon and Rectum: A Systematic Review of the Literature |
| title_full_unstemmed | Primary Squamous Cell Carcinoma of Colon and Rectum: A Systematic Review of the Literature |
| title_short | Primary Squamous Cell Carcinoma of Colon and Rectum: A Systematic Review of the Literature |
| title_sort | primary squamous cell carcinoma of colon and rectum a systematic review of the literature |
| topic | squamous cell carcinoma large intestine colon rectum rare neoplasms |
| url | http://dx.doi.org/10.1080/08941939.2020.1824044 |
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