Alzheimer’s Precision Neurology: Epigenetics of Cytochrome P450 Genes in Circulating Cell-Free DNA for Disease Prediction and Mechanism

Alzheimer’s Precision Neurology: Epigenetics of Cytochrome P450 Genes in Circulating Cell-Free DNA for Disease Prediction and Mechanism

Precision neurology combines high-throughput technologies and statistical modeling to identify novel disease pathways and predictive biomarkers in Alzheimer’s disease (AD). Brain cytochrome P450 (CYP) genes are major regulators of cholesterol, sex hormone, and xenobiotic metabolism, and they could p...

Full description

Bibliographic Details
Main Authors:	Ray O. Bahado-Singh, Sangeetha Vishweswaraiah, Onur Turkoglu, Stewart F. Graham, Uppala Radhakrishna
Format:	Article
Language:	English
Published:	MDPI AG 2023-02-01
Series:	International Journal of Molecular Sciences
Subjects:	cytochrome P450 CYP DNA methylation cell-free DNA Alzheimer’s disease
Online Access:	https://www.mdpi.com/1422-0067/24/3/2876

Similar Items

Cytochrome P450 genes expression in human prostate cancer
by: Oksana Maksymchuk, et al.
Published: (2024-03-01)

Placental cytochrome P450 methylomes in infants exposed to prenatal opioids: exploring the effects of neonatal opioid withdrawal syndrome on health horizons
by: Uppala Radhakrishna, et al.
Published: (2024-01-01)

Gene polymorphism of cytochrome P450 significantly affects lung cancer susceptibility
by: Meng Li, et al.
Published: (2019-08-01)

Pleiotropic Functions of Cytochrome P450 Monooxygenase-Derived Eicosanoids in Cancer
by: Ying Luo, et al.
Published: (2020-10-01)

Discovery of a cytochrome P450 enzyme catalyzing the formation of spirooxindole alkaloid scaffold
by: Tuan-Anh M. Nguyen, et al.
Published: (2023-02-01)

The cytochrome P450 isoenzyme and some new opportunities for the prediction of negative drug interaction in vivo
by: Sychev DA, et al.
Published: (2018-05-01)

Molecular Dynamics Simulations of a Cytochrome P450 from <i>Tepidiphilus thermophilus</i> (P450-TT) Reveal How Its Substrate-Binding Channel Opens
by: Abayomi S. Faponle, et al.
Published: (2021-06-01)

The use of active site mutants of cytochrome P450(cam) in chemical synthesis
by: Bell, S, et al.
Published: (1999)

Engineering cytochrome P450s for bioremediation /
by: 242771 Kellner, David G., et al.

Albendazole metabolism in patients with neurocysticercosis: antipyrine as a multifunctional marker drug of cytochrome P450
by: M.P. Marques, et al.
Published: (2002-02-01)

Engineering of daidzein 3’-hydroxylase P450 enzyme into catalytically self-sufficient cytochrome P450
by: Choi Kwon-Young, et al.
Published: (2012-06-01)

Precision oncology: Artificial intelligence, circulating cell‐free DNA, and the minimally invasive detection of pancreatic cancer—A pilot study
by: Ray O. Bahado‐Singh, et al.
Published: (2023-10-01)

Curcumin Prevents Aflatoxin B1 Hepatoxicity by Inhibition of Cytochrome P450 Isozymes in Chick Liver
by: Ni-Ya Zhang, et al.
Published: (2016-11-01)

Cytochrome P450 monooxygenase-mediated tailoring of triterpenoids and steroids in plants
by: Karan Malhotra, et al.
Published: (2022-09-01)

The FMN “140s Loop” of Cytochrome P450 Reductase Controls Electron Transfer to Cytochrome P450
by: Freeborn Rwere, et al.
Published: (2021-09-01)

Inhibitory effects of herbal medicines with claimed anticancer indications on cytochrome P450—An evaluation of drug-herb interactions risk
by: Misheck Mudyiwa, et al.
Published: (2023-09-01)

Stable Chinese Hamster Ovary Suspension Cell Lines Harboring Recombinant Human Cytochrome P450 Oxidoreductase and Human Cytochrome P450 Monooxygenases as Platform for In Vitro Biotransformation Studies
by: Christian Schulz, et al.
Published: (2023-08-01)

Hydroxylation of Antitubercular Drug Candidate, SQ109, by Mycobacterial Cytochrome P450
by: Sergey Bukhdruker, et al.
Published: (2020-10-01)

Optimization of the process parameters for reduction of gossypol levels in cottonseed meal by functional recombinant NADPH-cytochrome P450 reductase and cytochrome P450 CYP9A12 of Helicoverpa armigera
by: Cheng Chen, et al.
Published: (2019-07-01)

Interaction Modes of Microsomal Cytochrome P450s with Its Reductase and the Role of Substrate Binding
by: Francisco Esteves, et al.
Published: (2020-09-01)

Cytochrome P450 enzymes mediated by DNA methylation is involved in deoxynivalenol-induced hepatoxicity in piglets
by: Aimei Liu, et al.
Published: (2022-06-01)

Comparative Analysis of NADPH-Cytochrome P450 Reductases From Legumes for Heterologous Production of Triterpenoids in Transgenic Saccharomyces cerevisiae
by: Pramesti Istiandari, et al.
Published: (2021-12-01)

Modulatory effects of Benjakul extract on rat hepatic cytochrome P450 enzymes
by: Suchittra Samuhasaneeto, et al.
Published: (2021-11-01)

CYPminer: an automated cytochrome P450 identification, classification, and data analysis tool for genome data sets across kingdoms
by: Ohgew Kweon, et al.
Published: (2020-04-01)

Characteristics and roles of cytochrome b5 in cytochrome P450-mediated oxidative reactions in Locusta migratoria
by: Jiao LIU, et al.
Published: (2020-06-01)

Inhibition of Human Cytochrome P450 Enzymes by Bacopa monnieri Standardized Extract and Constituents
by: Seetha Ramasamy, et al.
Published: (2014-02-01)

Effects of Triflusal and Clopidogrel on the Secondary Prevention of Stroke Based on Cytochrome P450 2C19 Genotyping
by: Sang Won Han, et al.
Published: (2017-09-01)

INTRODUCTION OF AN N-GLYCOSYLATION SITE INTO UDP-GLUCURONOSYLTRANSFERASE 2B3 ALTERS ITS SENSITIVITY TO CYTOCHROME P450 3A1-DEPENDENT MODULATION
by: Tatsuro Nakamura, et al.
Published: (2016-11-01)

The Cytochrome P450-Mediated Metabolism Alternation of Four Effective Lignans From Schisandra chinensis in Carbon Tetrachloride-Intoxicated Rats and Patients With Advanced Hepatocellular Carcinoma
by: Rongrong Wu, et al.
Published: (2018-03-01)

Inhibitory effect of 20(S)-protopanaxadiol on cytochrome P450: Potential of its pharmacokinetic interactions in vivo
by: Su Gwon Lee, et al.
Published: (2022-09-01)

Isolation and characterization of the full-length cDNA encoding a member of a novel cytochrome p450 family (CYP320A1) from the tropical freshwater snail, Biomphalaria glabrata, intermediate host for Schistosoma mansoni
by: Anne E Lockyer, et al.
Published: (2005-05-01)

Bioactivation and Regioselectivity of Pig Cytochrome P450 3A29 towards Aflatoxin B1
by: Jun Wu, et al.
Published: (2016-09-01)

Cytochrome P450c17alpha (CYP17) gene polymorphism is not associated with leiomyoma susceptibility
by: Hsieh Yao-Yuan, et al.
Published: (2002-01-01)

Precision Oncology: Artificial Intelligence and DNA Methylation Analysis of Circulating Cell-Free DNA for Lung Cancer Detection
by: Ray Bahado-Singh, et al.
Published: (2022-05-01)

The Role of Cytochrome P450 Enzymes in COVID-19 Pathogenesis and Therapy
by: Guyi Wang, et al.
Published: (2022-02-01)

Intratumoural Cytochrome P450 Expression in Breast Cancer: Impact on Standard of Care Treatment and New Efforts to Develop Tumour-Selective Therapies
by: Smarakan Sneha, et al.
Published: (2021-03-01)

Phenoconversion of Cytochrome P450 Metabolism: A Systematic Review
by: Sylvia D. Klomp, et al.
Published: (2020-09-01)

Gut transcriptome analysis of P450 genes and cytochrome P450 reductase in three moth species feeding on gymnosperms or angiosperms
by: Xiaoman Zhang, et al.
Published: (2022-11-01)

Detoxification Cytochrome P450s (CYPs) in Families 1–3 Produce Functional Oxylipins from Polyunsaturated Fatty Acids
by: Jazmine A. Eccles, et al.
Published: (2022-12-01)

Interaction of rocuronium with human liver cytochromes P450
by: Eva Anzenbacherova, et al.
Published: (2015-02-01)