Diagnosis, treatment, and misdiagnosis analysis of 28 cases of central nervous system echinococcosis
Abstract Background To explore central nervous system (CNS) involvement in this disease, from the perspectives of diagnosis, treatment, and misdiagnosis Methods Twenty-eight patients with CNS echinococcosis were included in this retrospective study, including 18 males (64.3%) and 10 (35.7%) females....
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| Format: | Article |
| Language: | English |
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BMC
2021-05-01
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| Series: | Chinese Neurosurgical Journal |
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| Online Access: | https://doi.org/10.1186/s41016-021-00248-y |
| _version_ | 1818939932681437184 |
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| author | Guojia Du Yandong Li Pan Wu Xin Wang Riqing Su Yandong Fan Dangmurenjiafu Geng |
| author_facet | Guojia Du Yandong Li Pan Wu Xin Wang Riqing Su Yandong Fan Dangmurenjiafu Geng |
| author_sort | Guojia Du |
| collection | DOAJ |
| description | Abstract Background To explore central nervous system (CNS) involvement in this disease, from the perspectives of diagnosis, treatment, and misdiagnosis Methods Twenty-eight patients with CNS echinococcosis were included in this retrospective study, including 18 males (64.3%) and 10 (35.7%) females. The average age of all the patients were 23.5 years (ranged 4–60 years). Twenty-three (23) patients (82.1%) received the first surgical resection in our hospital. Five (5) patients (17.9%) gave up surgical treatment for multiple-organ hydatidosis and previous surgery history at other hospitals, and albendazole was applied for a long-term (3–6 months) adjunct therapy for the 5 patients. The average follow-up time was 8 years. Results For the 28 patients, 23 cases received surgical treatments, and the diagnosis was confirmed by pathological examinations. The diagnosis of 4 cases of brain echinococcosis and 2 cases of spinal cord echinococcosis could not be confirmed, resulting in a misdiagnosis rate of 21.4% (6/28). For the pathological examination, a total of 17 cases were infected with Echinococcus granulosus (including 2 cases of spinal cord echinococcosis), and 6 cases were infected with Echinococcus alveolaris. Conclusion The diagnosis should be specifically considered in endemic regions. The clinical features of CNS hydatidosis were intracranial space-occupying lesions. For the treatment, the surgical removal of cysts should be necessary. In addition, the adjuvant therapy with drug and intraoperative prophylaxis is also suggested. The misdiagnosis may have resulted from atypical clinical features and radiographic manifestations, as well as the accuracy of hydatid immunologic test. |
| first_indexed | 2024-12-20T06:31:36Z |
| format | Article |
| id | doaj.art-570f731cbc7c48a3b6eb21e0116227f8 |
| institution | Directory Open Access Journal |
| issn | 2057-4967 |
| language | English |
| last_indexed | 2024-12-20T06:31:36Z |
| publishDate | 2021-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Chinese Neurosurgical Journal |
| spelling | doaj.art-570f731cbc7c48a3b6eb21e0116227f82022-12-21T19:50:07ZengBMCChinese Neurosurgical Journal2057-49672021-05-01711610.1186/s41016-021-00248-yDiagnosis, treatment, and misdiagnosis analysis of 28 cases of central nervous system echinococcosisGuojia Du0Yandong Li1Pan Wu2Xin Wang3Riqing Su4Yandong Fan5Dangmurenjiafu Geng6Department of Neurosurgery, The First Teaching Hospital of Xinjiang Medical UniversityDepartment of Neurosurgery, The First Teaching Hospital of Xinjiang Medical UniversityDepartment of Neurosurgery, The First Teaching Hospital of Xinjiang Medical UniversityDepartment of Neurosurgery, The First Teaching Hospital of Xinjiang Medical UniversityDepartment of Neurosurgery, The First Teaching Hospital of Xinjiang Medical UniversityDepartment of Neurosurgery, The First Teaching Hospital of Xinjiang Medical UniversityDepartment of Neurosurgery, The First Teaching Hospital of Xinjiang Medical UniversityAbstract Background To explore central nervous system (CNS) involvement in this disease, from the perspectives of diagnosis, treatment, and misdiagnosis Methods Twenty-eight patients with CNS echinococcosis were included in this retrospective study, including 18 males (64.3%) and 10 (35.7%) females. The average age of all the patients were 23.5 years (ranged 4–60 years). Twenty-three (23) patients (82.1%) received the first surgical resection in our hospital. Five (5) patients (17.9%) gave up surgical treatment for multiple-organ hydatidosis and previous surgery history at other hospitals, and albendazole was applied for a long-term (3–6 months) adjunct therapy for the 5 patients. The average follow-up time was 8 years. Results For the 28 patients, 23 cases received surgical treatments, and the diagnosis was confirmed by pathological examinations. The diagnosis of 4 cases of brain echinococcosis and 2 cases of spinal cord echinococcosis could not be confirmed, resulting in a misdiagnosis rate of 21.4% (6/28). For the pathological examination, a total of 17 cases were infected with Echinococcus granulosus (including 2 cases of spinal cord echinococcosis), and 6 cases were infected with Echinococcus alveolaris. Conclusion The diagnosis should be specifically considered in endemic regions. The clinical features of CNS hydatidosis were intracranial space-occupying lesions. For the treatment, the surgical removal of cysts should be necessary. In addition, the adjuvant therapy with drug and intraoperative prophylaxis is also suggested. The misdiagnosis may have resulted from atypical clinical features and radiographic manifestations, as well as the accuracy of hydatid immunologic test.https://doi.org/10.1186/s41016-021-00248-yEchinococcosisCentral nervous systemDiagnosisTreatment |
| spellingShingle | Guojia Du Yandong Li Pan Wu Xin Wang Riqing Su Yandong Fan Dangmurenjiafu Geng Diagnosis, treatment, and misdiagnosis analysis of 28 cases of central nervous system echinococcosis Chinese Neurosurgical Journal Echinococcosis Central nervous system Diagnosis Treatment |
| title | Diagnosis, treatment, and misdiagnosis analysis of 28 cases of central nervous system echinococcosis |
| title_full | Diagnosis, treatment, and misdiagnosis analysis of 28 cases of central nervous system echinococcosis |
| title_fullStr | Diagnosis, treatment, and misdiagnosis analysis of 28 cases of central nervous system echinococcosis |
| title_full_unstemmed | Diagnosis, treatment, and misdiagnosis analysis of 28 cases of central nervous system echinococcosis |
| title_short | Diagnosis, treatment, and misdiagnosis analysis of 28 cases of central nervous system echinococcosis |
| title_sort | diagnosis treatment and misdiagnosis analysis of 28 cases of central nervous system echinococcosis |
| topic | Echinococcosis Central nervous system Diagnosis Treatment |
| url | https://doi.org/10.1186/s41016-021-00248-y |
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