Hemoadsorption Using CytoSorb<sup>®</sup> in Patients with Infective Endocarditis: A German-Based Budget Impact Analysis
A considerable number of infective endocarditis (IE) patients require cardiac surgery with an increased risk for postoperative sepsis. Intraoperative hemoadsorption may diminish the risk of postoperative hyperinflammation with potential economic implications for intensive care unit (ICU) occupation....
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Journal of Cardiovascular Development and Disease |
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| Online Access: | https://www.mdpi.com/2308-3425/10/9/366 |
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| author | Cristina Rao Franziska Preissing Matthias Thielmann Daniel Wendt Zaki Haidari Jurij Matija Kalisnik Lothar Daake Karl Traeger |
| author_facet | Cristina Rao Franziska Preissing Matthias Thielmann Daniel Wendt Zaki Haidari Jurij Matija Kalisnik Lothar Daake Karl Traeger |
| author_sort | Cristina Rao |
| collection | DOAJ |
| description | A considerable number of infective endocarditis (IE) patients require cardiac surgery with an increased risk for postoperative sepsis. Intraoperative hemoadsorption may diminish the risk of postoperative hyperinflammation with potential economic implications for intensive care unit (ICU) occupation. The present study aimed to theoretically investigate the budget impact of a reduced length of ICU stay in IE patients treated with intraoperative hemoadsorption in the German healthcare system. Data on ICU occupation were extrapolated from a retrospective study on IE patients treated with hemoadsorption. An Excel-based budget impact model was developed to simulate the patient course over the ICU stay. A base-case scenario without therapy reimbursement and a scenario with full therapy reimbursement were explored. The annual eligible German IE patient population was derived from official German Diagnostic-Related Group (DRG) volume data. One-way deterministic sensitivity analysis and multivariate analysis were performed to evaluate the uncertainty over the model results. The use of intraoperative hemoadsorption resulted in EUR 2298 being saved per patient in the base-case scenario without therapy reimbursement. The savings increased to EUR 3804 per patient in the case of full device-specific reimbursement. Deterministic and probabilistic sensitivity analyses confirmed the robustness of savings, with a probability of savings of 87% and 99% in the base-case and full reimbursement scenario, respectively. Intraoperative hemoadsorption in IE patients might have relevant economic benefits related to reduced ICU stays, resulting in improved resource use. Further evaluations in larger prospective cohorts are warranted. |
| first_indexed | 2024-03-10T22:38:07Z |
| format | Article |
| id | doaj.art-570f86f007e04a5faa4efcc56ab61f28 |
| institution | Directory Open Access Journal |
| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-03-10T22:38:07Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-570f86f007e04a5faa4efcc56ab61f282023-11-19T11:16:25ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252023-08-0110936610.3390/jcdd10090366Hemoadsorption Using CytoSorb<sup>®</sup> in Patients with Infective Endocarditis: A German-Based Budget Impact AnalysisCristina Rao0Franziska Preissing1Matthias Thielmann2Daniel Wendt3Zaki Haidari4Jurij Matija Kalisnik5Lothar Daake6Karl Traeger7CytoSorbents Europe, 12587 Berlin, GermanyCytoSorbents Europe, 12587 Berlin, GermanyDepartment of Thoracic and Cardiovascular Surgery, West-German Heart & Vascular Center, 45122 Essen, GermanyCytoSorbents Europe, 12587 Berlin, GermanyDepartment of Thoracic and Cardiovascular Surgery, West-German Heart & Vascular Center, 45122 Essen, GermanyDepartment of Cardiac Surgery, Klinikum Nürnberg, Paracelsus Medical University, 90419 Nuremberg, GermanyMedical Controlling Department, University of Essen, 45157 Essen, GermanyDepartment of Cardiac Anesthesiology, University Hospital Ulm, 89081 Ulm, GermanyA considerable number of infective endocarditis (IE) patients require cardiac surgery with an increased risk for postoperative sepsis. Intraoperative hemoadsorption may diminish the risk of postoperative hyperinflammation with potential economic implications for intensive care unit (ICU) occupation. The present study aimed to theoretically investigate the budget impact of a reduced length of ICU stay in IE patients treated with intraoperative hemoadsorption in the German healthcare system. Data on ICU occupation were extrapolated from a retrospective study on IE patients treated with hemoadsorption. An Excel-based budget impact model was developed to simulate the patient course over the ICU stay. A base-case scenario without therapy reimbursement and a scenario with full therapy reimbursement were explored. The annual eligible German IE patient population was derived from official German Diagnostic-Related Group (DRG) volume data. One-way deterministic sensitivity analysis and multivariate analysis were performed to evaluate the uncertainty over the model results. The use of intraoperative hemoadsorption resulted in EUR 2298 being saved per patient in the base-case scenario without therapy reimbursement. The savings increased to EUR 3804 per patient in the case of full device-specific reimbursement. Deterministic and probabilistic sensitivity analyses confirmed the robustness of savings, with a probability of savings of 87% and 99% in the base-case and full reimbursement scenario, respectively. Intraoperative hemoadsorption in IE patients might have relevant economic benefits related to reduced ICU stays, resulting in improved resource use. Further evaluations in larger prospective cohorts are warranted.https://www.mdpi.com/2308-3425/10/9/366acute infective endocarditisextracorporeal techniqueshemoadsorptioncytosorbcardiopulmonary bypass surgeryeconomic evaluation |
| spellingShingle | Cristina Rao Franziska Preissing Matthias Thielmann Daniel Wendt Zaki Haidari Jurij Matija Kalisnik Lothar Daake Karl Traeger Hemoadsorption Using CytoSorb<sup>®</sup> in Patients with Infective Endocarditis: A German-Based Budget Impact Analysis Journal of Cardiovascular Development and Disease acute infective endocarditis extracorporeal techniques hemoadsorption cytosorb cardiopulmonary bypass surgery economic evaluation |
| title | Hemoadsorption Using CytoSorb<sup>®</sup> in Patients with Infective Endocarditis: A German-Based Budget Impact Analysis |
| title_full | Hemoadsorption Using CytoSorb<sup>®</sup> in Patients with Infective Endocarditis: A German-Based Budget Impact Analysis |
| title_fullStr | Hemoadsorption Using CytoSorb<sup>®</sup> in Patients with Infective Endocarditis: A German-Based Budget Impact Analysis |
| title_full_unstemmed | Hemoadsorption Using CytoSorb<sup>®</sup> in Patients with Infective Endocarditis: A German-Based Budget Impact Analysis |
| title_short | Hemoadsorption Using CytoSorb<sup>®</sup> in Patients with Infective Endocarditis: A German-Based Budget Impact Analysis |
| title_sort | hemoadsorption using cytosorb sup r sup in patients with infective endocarditis a german based budget impact analysis |
| topic | acute infective endocarditis extracorporeal techniques hemoadsorption cytosorb cardiopulmonary bypass surgery economic evaluation |
| url | https://www.mdpi.com/2308-3425/10/9/366 |
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