Genomic and Glycolytic Entropy Are Reliable Radiogenomic Heterogeneity Biomarkers for Non-Small Cell Lung Cancer
Radiogenomic heterogeneity features in <sup>18</sup>F-fluorodeoxyglucose positron emission tomography (<sup>18</sup>F-FDG PET) have become popular in non-small cell lung cancer (NSCLC) research. However, the reliabilities of genomic heterogeneity features and of PET-based gly...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/4/3988 |
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| author | Yu-Hung Chen Kun-Han Lue Chih-Bin Lin Kuang-Chi Chen Sheng-Chieh Chan Sung-Chao Chu Bee-Song Chang Yen-Chang Chen |
| author_facet | Yu-Hung Chen Kun-Han Lue Chih-Bin Lin Kuang-Chi Chen Sheng-Chieh Chan Sung-Chao Chu Bee-Song Chang Yen-Chang Chen |
| author_sort | Yu-Hung Chen |
| collection | DOAJ |
| description | Radiogenomic heterogeneity features in <sup>18</sup>F-fluorodeoxyglucose positron emission tomography (<sup>18</sup>F-FDG PET) have become popular in non-small cell lung cancer (NSCLC) research. However, the reliabilities of genomic heterogeneity features and of PET-based glycolytic features in different image matrix sizes have yet to be thoroughly tested. We conducted a prospective study with 46 NSCLC patients to assess the intra-class correlation coefficient (ICC) of different genomic heterogeneity features. We also tested the ICC of PET-based heterogeneity features from different image matrix sizes. The association of radiogenomic features with clinical data was also examined. The entropy-based genomic heterogeneity feature (ICC = 0.736) is more reliable than the median-based feature (ICC = −0.416). The PET-based glycolytic entropy was insensitive to image matrix size change (ICC = 0.958) and remained reliable in tumors with a metabolic volume of <10 mL (ICC = 0.894). The glycolytic entropy is also significantly associated with advanced cancer stages (<i>p</i> = 0.011). We conclude that the entropy-based radiogenomic features are reliable and may serve as ideal biomarkers for research and further clinical use for NSCLC. |
| first_indexed | 2024-03-11T08:41:48Z |
| format | Article |
| id | doaj.art-570fb75fd57f4a26883f8a044f978fd3 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T08:41:48Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-570fb75fd57f4a26883f8a044f978fd32023-11-16T21:07:55ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-02-01244398810.3390/ijms24043988Genomic and Glycolytic Entropy Are Reliable Radiogenomic Heterogeneity Biomarkers for Non-Small Cell Lung CancerYu-Hung Chen0Kun-Han Lue1Chih-Bin Lin2Kuang-Chi Chen3Sheng-Chieh Chan4Sung-Chao Chu5Bee-Song Chang6Yen-Chang Chen7Department of Nuclear Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97002, TaiwanDepartment of Medical Imaging and Radiological Sciences, Tzu Chi University of Science and Technology, Hualien 97005, TaiwanDepartment of Internal Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97002, TaiwanDepartment of Medical Informatics, Tzu Chi University, Hualien 97004, TaiwanDepartment of Nuclear Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97002, TaiwanSchool of Medicine, College of Medicine, Tzu Chi University, Hualien 97004, TaiwanDepartment of Cardiothoracic Surgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97002, TaiwanSchool of Medicine, College of Medicine, Tzu Chi University, Hualien 97004, TaiwanRadiogenomic heterogeneity features in <sup>18</sup>F-fluorodeoxyglucose positron emission tomography (<sup>18</sup>F-FDG PET) have become popular in non-small cell lung cancer (NSCLC) research. However, the reliabilities of genomic heterogeneity features and of PET-based glycolytic features in different image matrix sizes have yet to be thoroughly tested. We conducted a prospective study with 46 NSCLC patients to assess the intra-class correlation coefficient (ICC) of different genomic heterogeneity features. We also tested the ICC of PET-based heterogeneity features from different image matrix sizes. The association of radiogenomic features with clinical data was also examined. The entropy-based genomic heterogeneity feature (ICC = 0.736) is more reliable than the median-based feature (ICC = −0.416). The PET-based glycolytic entropy was insensitive to image matrix size change (ICC = 0.958) and remained reliable in tumors with a metabolic volume of <10 mL (ICC = 0.894). The glycolytic entropy is also significantly associated with advanced cancer stages (<i>p</i> = 0.011). We conclude that the entropy-based radiogenomic features are reliable and may serve as ideal biomarkers for research and further clinical use for NSCLC.https://www.mdpi.com/1422-0067/24/4/3988tumor heterogeneitywhole exome sequencing<sup>18</sup>F-FDG PETmolecular imaginglung cancer |
| spellingShingle | Yu-Hung Chen Kun-Han Lue Chih-Bin Lin Kuang-Chi Chen Sheng-Chieh Chan Sung-Chao Chu Bee-Song Chang Yen-Chang Chen Genomic and Glycolytic Entropy Are Reliable Radiogenomic Heterogeneity Biomarkers for Non-Small Cell Lung Cancer International Journal of Molecular Sciences tumor heterogeneity whole exome sequencing <sup>18</sup>F-FDG PET molecular imaging lung cancer |
| title | Genomic and Glycolytic Entropy Are Reliable Radiogenomic Heterogeneity Biomarkers for Non-Small Cell Lung Cancer |
| title_full | Genomic and Glycolytic Entropy Are Reliable Radiogenomic Heterogeneity Biomarkers for Non-Small Cell Lung Cancer |
| title_fullStr | Genomic and Glycolytic Entropy Are Reliable Radiogenomic Heterogeneity Biomarkers for Non-Small Cell Lung Cancer |
| title_full_unstemmed | Genomic and Glycolytic Entropy Are Reliable Radiogenomic Heterogeneity Biomarkers for Non-Small Cell Lung Cancer |
| title_short | Genomic and Glycolytic Entropy Are Reliable Radiogenomic Heterogeneity Biomarkers for Non-Small Cell Lung Cancer |
| title_sort | genomic and glycolytic entropy are reliable radiogenomic heterogeneity biomarkers for non small cell lung cancer |
| topic | tumor heterogeneity whole exome sequencing <sup>18</sup>F-FDG PET molecular imaging lung cancer |
| url | https://www.mdpi.com/1422-0067/24/4/3988 |
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