A narrative review of the therapeutic and remedial prospects of cannabidiol with emphasis on neurological and neuropsychiatric disorders
Abstract Background The treatment of diverse diseases using plant-derived products is actively encouraged. In the past few years, cannabidiol (CBD) has emerged as a potent cannabis-derived drug capable of managing various debilitating neurological infections, diseases, and their associated complicat...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-03-01
|
| Series: | Journal of Cannabis Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s42238-024-00222-2 |
| _version_ | 1797247062830481408 |
|---|---|
| author | Oluwadara Pelumi Omotayo Yolandy Lemmer Shayne Mason |
| author_facet | Oluwadara Pelumi Omotayo Yolandy Lemmer Shayne Mason |
| author_sort | Oluwadara Pelumi Omotayo |
| collection | DOAJ |
| description | Abstract Background The treatment of diverse diseases using plant-derived products is actively encouraged. In the past few years, cannabidiol (CBD) has emerged as a potent cannabis-derived drug capable of managing various debilitating neurological infections, diseases, and their associated complications. CBD has demonstrated anti-inflammatory and curative effects in neuropathological conditions, and it exhibits therapeutic, apoptotic, anxiolytic, and neuroprotective properties. However, more information on the reactions and ability of CBD to alleviate brain-related disorders and the neuroinflammation that accompanies them is needed. Main body This narrative review deliberates on the therapeutic and remedial prospects of CBD with an emphasis on neurological and neuropsychiatric disorders. An extensive literature search followed several scoping searches on available online databases such as PubMed, Web of Science, and Scopus with the main keywords: CBD, pro-inflammatory cytokines, and cannabinoids. After a purposive screening of the retrieved papers, 170 (41%) of the articles (published in English) aligned with the objective of this study and retained for inclusion. Conclusion CBD is an antagonist against pro-inflammatory cytokines and the cytokine storm associated with neurological infections/disorders. CBD regulates adenosine/oxidative stress and aids the downregulation of TNF-α, restoration of BDNF mRNA expression, and recovery of serotonin levels. Thus, CBD is involved in immune suppression and anti-inflammation. Understanding the metabolites associated with response to CBD is imperative to understand the phenotype. We propose that metabolomics will be the next scientific frontier that will reveal novel information on CBD’s therapeutic tendencies in neurological/neuropsychiatric disorders. |
| first_indexed | 2024-04-24T19:52:44Z |
| format | Article |
| id | doaj.art-57108aba3adf433a861833a696279f66 |
| institution | Directory Open Access Journal |
| issn | 2522-5782 |
| language | English |
| last_indexed | 2024-04-24T19:52:44Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Cannabis Research |
| spelling | doaj.art-57108aba3adf433a861833a696279f662024-03-24T12:32:31ZengBMCJournal of Cannabis Research2522-57822024-03-016112610.1186/s42238-024-00222-2A narrative review of the therapeutic and remedial prospects of cannabidiol with emphasis on neurological and neuropsychiatric disordersOluwadara Pelumi Omotayo0Yolandy Lemmer1Shayne Mason2Human Metabolomics, Faculty of Natural and Agricultural Sciences, North-West UniversityCouncil for Scientific and Industrial Research (CSIR), Next Generation HealthHuman Metabolomics, Faculty of Natural and Agricultural Sciences, North-West UniversityAbstract Background The treatment of diverse diseases using plant-derived products is actively encouraged. In the past few years, cannabidiol (CBD) has emerged as a potent cannabis-derived drug capable of managing various debilitating neurological infections, diseases, and their associated complications. CBD has demonstrated anti-inflammatory and curative effects in neuropathological conditions, and it exhibits therapeutic, apoptotic, anxiolytic, and neuroprotective properties. However, more information on the reactions and ability of CBD to alleviate brain-related disorders and the neuroinflammation that accompanies them is needed. Main body This narrative review deliberates on the therapeutic and remedial prospects of CBD with an emphasis on neurological and neuropsychiatric disorders. An extensive literature search followed several scoping searches on available online databases such as PubMed, Web of Science, and Scopus with the main keywords: CBD, pro-inflammatory cytokines, and cannabinoids. After a purposive screening of the retrieved papers, 170 (41%) of the articles (published in English) aligned with the objective of this study and retained for inclusion. Conclusion CBD is an antagonist against pro-inflammatory cytokines and the cytokine storm associated with neurological infections/disorders. CBD regulates adenosine/oxidative stress and aids the downregulation of TNF-α, restoration of BDNF mRNA expression, and recovery of serotonin levels. Thus, CBD is involved in immune suppression and anti-inflammation. Understanding the metabolites associated with response to CBD is imperative to understand the phenotype. We propose that metabolomics will be the next scientific frontier that will reveal novel information on CBD’s therapeutic tendencies in neurological/neuropsychiatric disorders.https://doi.org/10.1186/s42238-024-00222-2Anti-inflammatory cytokinesCannabidiol (CBD)NeuroinflammationNeurological infectionsNeurological/neuropsychiatric disordersProinflammatory cytokines |
| spellingShingle | Oluwadara Pelumi Omotayo Yolandy Lemmer Shayne Mason A narrative review of the therapeutic and remedial prospects of cannabidiol with emphasis on neurological and neuropsychiatric disorders Journal of Cannabis Research Anti-inflammatory cytokines Cannabidiol (CBD) Neuroinflammation Neurological infections Neurological/neuropsychiatric disorders Proinflammatory cytokines |
| title | A narrative review of the therapeutic and remedial prospects of cannabidiol with emphasis on neurological and neuropsychiatric disorders |
| title_full | A narrative review of the therapeutic and remedial prospects of cannabidiol with emphasis on neurological and neuropsychiatric disorders |
| title_fullStr | A narrative review of the therapeutic and remedial prospects of cannabidiol with emphasis on neurological and neuropsychiatric disorders |
| title_full_unstemmed | A narrative review of the therapeutic and remedial prospects of cannabidiol with emphasis on neurological and neuropsychiatric disorders |
| title_short | A narrative review of the therapeutic and remedial prospects of cannabidiol with emphasis on neurological and neuropsychiatric disorders |
| title_sort | narrative review of the therapeutic and remedial prospects of cannabidiol with emphasis on neurological and neuropsychiatric disorders |
| topic | Anti-inflammatory cytokines Cannabidiol (CBD) Neuroinflammation Neurological infections Neurological/neuropsychiatric disorders Proinflammatory cytokines |
| url | https://doi.org/10.1186/s42238-024-00222-2 |
| work_keys_str_mv | AT oluwadarapelumiomotayo anarrativereviewofthetherapeuticandremedialprospectsofcannabidiolwithemphasisonneurologicalandneuropsychiatricdisorders AT yolandylemmer anarrativereviewofthetherapeuticandremedialprospectsofcannabidiolwithemphasisonneurologicalandneuropsychiatricdisorders AT shaynemason anarrativereviewofthetherapeuticandremedialprospectsofcannabidiolwithemphasisonneurologicalandneuropsychiatricdisorders AT oluwadarapelumiomotayo narrativereviewofthetherapeuticandremedialprospectsofcannabidiolwithemphasisonneurologicalandneuropsychiatricdisorders AT yolandylemmer narrativereviewofthetherapeuticandremedialprospectsofcannabidiolwithemphasisonneurologicalandneuropsychiatricdisorders AT shaynemason narrativereviewofthetherapeuticandremedialprospectsofcannabidiolwithemphasisonneurologicalandneuropsychiatricdisorders |