Efficacy of intracuff lidocaine in reducing coughing on tube: a systematic review and meta-analysis
Objective To investigate the efficacy of intracuff lidocaine in reducing coughing and other endotracheal tube side effects and so ensure a smooth extubation process. Method PubMed, EMBASE, and Cochrane Library databases were systematically searched for all randomised controlled trials (RCTs) publish...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2020-02-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/0300060520901872 |
| _version_ | 1819045701607227392 |
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| author | Fei Peng Maohua Wang Huihuang Yang Xiaoli Yang Menghong Long |
| author_facet | Fei Peng Maohua Wang Huihuang Yang Xiaoli Yang Menghong Long |
| author_sort | Fei Peng |
| collection | DOAJ |
| description | Objective To investigate the efficacy of intracuff lidocaine in reducing coughing and other endotracheal tube side effects and so ensure a smooth extubation process. Method PubMed, EMBASE, and Cochrane Library databases were systematically searched for all randomised controlled trials (RCTs) published before June 30, 2019 that investigated the efficacy of intracuff lidocaine, with or without sodium bicarbonate, in reducing coughing and other complications related to endotracheal intubation. A random-effects model was used to conduct a meta-analysis to assess the relative risks (RRs) of the incidence of these intubation-related side effects. Results 11 studies involving 843 patients were included in the meta-analysis. Compared with control groups (i.e., saline or air), intracuff lidocaine groups (alkalinized or non-alkalinized) had a significantly reduced incidence of coughing on tube. Similarly, intracuff lidocaine groups were more effective than control groups in reducing the incidence of other intubation-related complications. Conclusion Intracuff alkalinized or non-alkalinized lidocaine significantly reduced coughing and other intubation-related complications during the extubation process. |
| first_indexed | 2024-12-21T10:32:45Z |
| format | Article |
| id | doaj.art-571286cac4bf461aa40827df79ea5ffa |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-12-21T10:32:45Z |
| publishDate | 2020-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-571286cac4bf461aa40827df79ea5ffa2022-12-21T19:07:10ZengSAGE PublishingJournal of International Medical Research1473-23002020-02-014810.1177/0300060520901872Efficacy of intracuff lidocaine in reducing coughing on tube: a systematic review and meta-analysisFei PengMaohua WangHuihuang YangXiaoli YangMenghong LongObjective To investigate the efficacy of intracuff lidocaine in reducing coughing and other endotracheal tube side effects and so ensure a smooth extubation process. Method PubMed, EMBASE, and Cochrane Library databases were systematically searched for all randomised controlled trials (RCTs) published before June 30, 2019 that investigated the efficacy of intracuff lidocaine, with or without sodium bicarbonate, in reducing coughing and other complications related to endotracheal intubation. A random-effects model was used to conduct a meta-analysis to assess the relative risks (RRs) of the incidence of these intubation-related side effects. Results 11 studies involving 843 patients were included in the meta-analysis. Compared with control groups (i.e., saline or air), intracuff lidocaine groups (alkalinized or non-alkalinized) had a significantly reduced incidence of coughing on tube. Similarly, intracuff lidocaine groups were more effective than control groups in reducing the incidence of other intubation-related complications. Conclusion Intracuff alkalinized or non-alkalinized lidocaine significantly reduced coughing and other intubation-related complications during the extubation process.https://doi.org/10.1177/0300060520901872 |
| spellingShingle | Fei Peng Maohua Wang Huihuang Yang Xiaoli Yang Menghong Long Efficacy of intracuff lidocaine in reducing coughing on tube: a systematic review and meta-analysis Journal of International Medical Research |
| title | Efficacy of intracuff lidocaine in reducing coughing on tube: a systematic review and meta-analysis |
| title_full | Efficacy of intracuff lidocaine in reducing coughing on tube: a systematic review and meta-analysis |
| title_fullStr | Efficacy of intracuff lidocaine in reducing coughing on tube: a systematic review and meta-analysis |
| title_full_unstemmed | Efficacy of intracuff lidocaine in reducing coughing on tube: a systematic review and meta-analysis |
| title_short | Efficacy of intracuff lidocaine in reducing coughing on tube: a systematic review and meta-analysis |
| title_sort | efficacy of intracuff lidocaine in reducing coughing on tube a systematic review and meta analysis |
| url | https://doi.org/10.1177/0300060520901872 |
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