Pancreatic Stellate Cells and the Targeted Therapeutic Strategies in Chronic Pancreatitis
Chronic pancreatitis (CP) is a disease characterized by inflammatory recurrence that accompanies the development of pancreatic fibrosis. As the mystery of CP pathogenesis is gradually revealed, accumulating evidence suggests that the activation of pancreatic stellate cells (PSCs) and the appearance...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/14/5586 |
| _version_ | 1797588002964242432 |
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| author | Man Chang Wenjuan Chen Ruting Xia Yangyue Peng Pandi Niu Hui Fan |
| author_facet | Man Chang Wenjuan Chen Ruting Xia Yangyue Peng Pandi Niu Hui Fan |
| author_sort | Man Chang |
| collection | DOAJ |
| description | Chronic pancreatitis (CP) is a disease characterized by inflammatory recurrence that accompanies the development of pancreatic fibrosis. As the mystery of CP pathogenesis is gradually revealed, accumulating evidence suggests that the activation of pancreatic stellate cells (PSCs) and the appearance of a myofibroblast-like phenotype are the key gatekeepers in the development of CP. Targeting PSCs to prevent their activation and conversion to a myofibroblast-like phenotype, as well as increasing antioxidant capacity to counteract ongoing oxidative stress, are effective strategies for preventing or treating CP. Therefore, we reviewed the crosstalk between CP and pancreatic fibrosis, summarized the activation mechanisms of PSCs, and investigated potential CP therapeutic strategies targeting PSCs, including, but not limited to, anti-fibrosis therapy, antioxidant therapy, and gene therapy. Meanwhile, the above therapeutic strategies are selected in order to update the available phytopharmaceuticals as novel complementary or alternative approaches for the prevention and treatment of CP to clarify their potential mechanisms of action and their relevant molecular targets, aiming to provide the most comprehensive therapeutic treatment direction for CP and to bring new hope to CP patients. |
| first_indexed | 2024-03-11T00:46:53Z |
| format | Article |
| id | doaj.art-5718971b581f4c748ce1952fe8ccc53a |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T00:46:53Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-5718971b581f4c748ce1952fe8ccc53a2023-11-18T20:44:16ZengMDPI AGMolecules1420-30492023-07-012814558610.3390/molecules28145586Pancreatic Stellate Cells and the Targeted Therapeutic Strategies in Chronic PancreatitisMan Chang0Wenjuan Chen1Ruting Xia2Yangyue Peng3Pandi Niu4Hui Fan5Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangzhou 510006, ChinaGuangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangzhou 510006, ChinaGuangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangzhou 510006, ChinaGuangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangzhou 510006, ChinaGuangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangzhou 510006, ChinaGuangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangzhou 510006, ChinaChronic pancreatitis (CP) is a disease characterized by inflammatory recurrence that accompanies the development of pancreatic fibrosis. As the mystery of CP pathogenesis is gradually revealed, accumulating evidence suggests that the activation of pancreatic stellate cells (PSCs) and the appearance of a myofibroblast-like phenotype are the key gatekeepers in the development of CP. Targeting PSCs to prevent their activation and conversion to a myofibroblast-like phenotype, as well as increasing antioxidant capacity to counteract ongoing oxidative stress, are effective strategies for preventing or treating CP. Therefore, we reviewed the crosstalk between CP and pancreatic fibrosis, summarized the activation mechanisms of PSCs, and investigated potential CP therapeutic strategies targeting PSCs, including, but not limited to, anti-fibrosis therapy, antioxidant therapy, and gene therapy. Meanwhile, the above therapeutic strategies are selected in order to update the available phytopharmaceuticals as novel complementary or alternative approaches for the prevention and treatment of CP to clarify their potential mechanisms of action and their relevant molecular targets, aiming to provide the most comprehensive therapeutic treatment direction for CP and to bring new hope to CP patients.https://www.mdpi.com/1420-3049/28/14/5586chronic pancreatitispancreatic fibrosispancreatic stellate cellstherapeutic strategies |
| spellingShingle | Man Chang Wenjuan Chen Ruting Xia Yangyue Peng Pandi Niu Hui Fan Pancreatic Stellate Cells and the Targeted Therapeutic Strategies in Chronic Pancreatitis Molecules chronic pancreatitis pancreatic fibrosis pancreatic stellate cells therapeutic strategies |
| title | Pancreatic Stellate Cells and the Targeted Therapeutic Strategies in Chronic Pancreatitis |
| title_full | Pancreatic Stellate Cells and the Targeted Therapeutic Strategies in Chronic Pancreatitis |
| title_fullStr | Pancreatic Stellate Cells and the Targeted Therapeutic Strategies in Chronic Pancreatitis |
| title_full_unstemmed | Pancreatic Stellate Cells and the Targeted Therapeutic Strategies in Chronic Pancreatitis |
| title_short | Pancreatic Stellate Cells and the Targeted Therapeutic Strategies in Chronic Pancreatitis |
| title_sort | pancreatic stellate cells and the targeted therapeutic strategies in chronic pancreatitis |
| topic | chronic pancreatitis pancreatic fibrosis pancreatic stellate cells therapeutic strategies |
| url | https://www.mdpi.com/1420-3049/28/14/5586 |
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