Acute effects of Nitrosigine® and citrulline malate on vasodilation in young adults
Background Athletes are increasingly exploring ways to enhance their physical performance. Increasing blood flow to the working tissues through endothelium-dependent vasodilation is one factor athletes use to realize these results. Sports supplements such as pre-workouts tout this benefit; however,...
| প্রধান লেখক: | , , |
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| বিন্যাস: | প্রবন্ধ |
| ভাষা: | English |
| প্রকাশিত: |
Taylor & Francis Group
2020-02-01
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| মালা: | Journal of the International Society of Sports Nutrition |
| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | http://dx.doi.org/10.1186/s12970-020-00343-y |
| _version_ | 1827817756181921792 |
|---|---|
| author | Jeffrey M. Rogers Joshua Gills Michelle Gray |
| author_facet | Jeffrey M. Rogers Joshua Gills Michelle Gray |
| author_sort | Jeffrey M. Rogers |
| collection | DOAJ |
| description | Background Athletes are increasingly exploring ways to enhance their physical performance. Increasing blood flow to the working tissues through endothelium-dependent vasodilation is one factor athletes use to realize these results. Sports supplements such as pre-workouts tout this benefit; however, many have not been tested under laboratory conditions to examine the effects of commonly used supplements on vasodilation. Two popular supplements are Nitrosigine® and citrulline malate (CM). Thus, the purpose of this experiment was to determine the effects of Nitrosigine and CM on vasodilation using ultrasound and flow mediated dilation (FMD). Methods Healthy, normotensive, and physically active male (n = 16) and female (n = 8) young adults participated in the present investigation. We utilized a randomized, double-blind, within-subjects design where participants reported for three trials, each preceded by a 7-day washout period. Baseline FMD measurement was obtained for each visit, followed by consumption of one clinical dose CM (8 g), Nitrosigine (1.5 g), or dextrose placebo (8 g). Following a 60-min digestion period, FMD was repeated. Supplementation order was randomized controlling for potential order effects. Results Repeated measures ANOVA yielded a significant supplement (3) x time (2) effect (p < .001), such that Nitrosigine and CM yielded a greater improvement in FMD response than placebo. After supplementation, Nitrosigine and CM increased FMD by 31 and 34%, respectively, compared to a decrease of 2% during the placebo trial. After allometric scaling of the FMD values, supplement x time effect remained significant (p = .001) and changes were similar to non-scaled results. Nitrosigine (23%) and CM (25%) generated significantly greater allometric scaled FMD values when compared to the placebo trial (0.60%). Discussion Both Nitrisigine and CM increased endothelial-dependent vasodilation as measured by a change in FMD. Increased vasodilation leads to an increase in skeletal muscle blood flow resulting in potential improvements in exercise performance. |
| first_indexed | 2024-03-12T00:38:09Z |
| format | Article |
| id | doaj.art-571cd6843b1b45cfb743f0d4d5942088 |
| institution | Directory Open Access Journal |
| issn | 1550-2783 |
| language | English |
| last_indexed | 2024-03-12T00:38:09Z |
| publishDate | 2020-02-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of the International Society of Sports Nutrition |
| spelling | doaj.art-571cd6843b1b45cfb743f0d4d59420882023-09-15T09:19:31ZengTaylor & Francis GroupJournal of the International Society of Sports Nutrition1550-27832020-02-0117110.1186/s12970-020-00343-y12130153Acute effects of Nitrosigine® and citrulline malate on vasodilation in young adultsJeffrey M. Rogers0Joshua Gills1Michelle Gray2Exercise Science Research CenterExercise Science Research CenterExercise Science Research CenterBackground Athletes are increasingly exploring ways to enhance their physical performance. Increasing blood flow to the working tissues through endothelium-dependent vasodilation is one factor athletes use to realize these results. Sports supplements such as pre-workouts tout this benefit; however, many have not been tested under laboratory conditions to examine the effects of commonly used supplements on vasodilation. Two popular supplements are Nitrosigine® and citrulline malate (CM). Thus, the purpose of this experiment was to determine the effects of Nitrosigine and CM on vasodilation using ultrasound and flow mediated dilation (FMD). Methods Healthy, normotensive, and physically active male (n = 16) and female (n = 8) young adults participated in the present investigation. We utilized a randomized, double-blind, within-subjects design where participants reported for three trials, each preceded by a 7-day washout period. Baseline FMD measurement was obtained for each visit, followed by consumption of one clinical dose CM (8 g), Nitrosigine (1.5 g), or dextrose placebo (8 g). Following a 60-min digestion period, FMD was repeated. Supplementation order was randomized controlling for potential order effects. Results Repeated measures ANOVA yielded a significant supplement (3) x time (2) effect (p < .001), such that Nitrosigine and CM yielded a greater improvement in FMD response than placebo. After supplementation, Nitrosigine and CM increased FMD by 31 and 34%, respectively, compared to a decrease of 2% during the placebo trial. After allometric scaling of the FMD values, supplement x time effect remained significant (p = .001) and changes were similar to non-scaled results. Nitrosigine (23%) and CM (25%) generated significantly greater allometric scaled FMD values when compared to the placebo trial (0.60%). Discussion Both Nitrisigine and CM increased endothelial-dependent vasodilation as measured by a change in FMD. Increased vasodilation leads to an increase in skeletal muscle blood flow resulting in potential improvements in exercise performance.http://dx.doi.org/10.1186/s12970-020-00343-ycitrulline malatearginine silicatenitrosigine®flow mediated dilationvasodilation |
| spellingShingle | Jeffrey M. Rogers Joshua Gills Michelle Gray Acute effects of Nitrosigine® and citrulline malate on vasodilation in young adults Journal of the International Society of Sports Nutrition citrulline malate arginine silicate nitrosigine® flow mediated dilation vasodilation |
| title | Acute effects of Nitrosigine® and citrulline malate on vasodilation in young adults |
| title_full | Acute effects of Nitrosigine® and citrulline malate on vasodilation in young adults |
| title_fullStr | Acute effects of Nitrosigine® and citrulline malate on vasodilation in young adults |
| title_full_unstemmed | Acute effects of Nitrosigine® and citrulline malate on vasodilation in young adults |
| title_short | Acute effects of Nitrosigine® and citrulline malate on vasodilation in young adults |
| title_sort | acute effects of nitrosigine r and citrulline malate on vasodilation in young adults |
| topic | citrulline malate arginine silicate nitrosigine® flow mediated dilation vasodilation |
| url | http://dx.doi.org/10.1186/s12970-020-00343-y |
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