Functioning pituitary tumours: Hints from the skin
We introduce dermatological aspects from an endocrine point of view related to pituitary tumours that display active secretor activity. This is a short literature review. 40 papers are cited including narrative reviews and original studies. Acromegaly: GH overproduction causes the thickening of the...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Amaltea Medical Publishing House
2020-03-01
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| Series: | Romanian Medical Journal |
| Subjects: | |
| Online Access: | https://rmj.com.ro/articles/2020.1/RMJ_2020_1_Art-01.pdf |
| _version_ | 1827361657029918720 |
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| author | Florica Sandru Ana Valea Simona Elena Albu Mihai Cristian Dumitrascu Constantin Dumitrache Ana Maria Alexandra Stanescu Mara Carsote |
| author_facet | Florica Sandru Ana Valea Simona Elena Albu Mihai Cristian Dumitrascu Constantin Dumitrache Ana Maria Alexandra Stanescu Mara Carsote |
| author_sort | Florica Sandru |
| collection | DOAJ |
| description | We introduce dermatological aspects from an endocrine point of view related to pituitary tumours that display active secretor activity. This is a short literature review. 40 papers are cited including narrative reviews and original studies. Acromegaly: GH overproduction causes the thickening of the skin and swelling of the soft tissues in addition to the enlargement of extremities (like nose, hands, feet, jaw), coarsening of facial features (as front head and naso-labial folds), excessive sweating, exaggerate skin wrinkles, oily skin, and acrochordons. Cushing’s disease: cortisol overproduction has a severe protein catabolic effect at skin with collagen network disruption while immune effect of hypercortisolemia induces chronic skin infections and difficulties in wound healing. In females, consecutive androgens excess induces acne, hirsutism, and androgens-related alopecia. The classical phenotype includes: fragile skin or skin atrophy, red/purple striae, easy bruising, facial plethora. Skin changes represent the window to pituitary tumours for clinicians of different specialities, therefore contributing to final diagnosis of endocrinopathies. |
| first_indexed | 2024-03-08T07:09:33Z |
| format | Article |
| id | doaj.art-571d4f8cdfaf443fb6f6238712402dae |
| institution | Directory Open Access Journal |
| issn | 1220-5478 2069-606X |
| language | English |
| last_indexed | 2024-03-08T07:09:33Z |
| publishDate | 2020-03-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Medical Journal |
| spelling | doaj.art-571d4f8cdfaf443fb6f6238712402dae2024-02-03T03:30:47ZengAmaltea Medical Publishing HouseRomanian Medical Journal1220-54782069-606X2020-03-016715910.37897/RMJ.2020.1.1Functioning pituitary tumours: Hints from the skin Florica Sandru0Ana Valea1Simona Elena Albu2Mihai Cristian Dumitrascu3Constantin Dumitrache4Ana Maria Alexandra Stanescu5Mara Carsote6“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; Elias Emergency University Hospital, Bucharest, Romania Clinical County Hospital, Cluj-Napoca, Romania; “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; Emergency University Hospital, Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; Emergency University Hospital, Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; “C.I. Parhon” National Institute of Endocrinology, Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; “C.I. Parhon” National Institute of Endocrinology, Bucharest, RomaniaWe introduce dermatological aspects from an endocrine point of view related to pituitary tumours that display active secretor activity. This is a short literature review. 40 papers are cited including narrative reviews and original studies. Acromegaly: GH overproduction causes the thickening of the skin and swelling of the soft tissues in addition to the enlargement of extremities (like nose, hands, feet, jaw), coarsening of facial features (as front head and naso-labial folds), excessive sweating, exaggerate skin wrinkles, oily skin, and acrochordons. Cushing’s disease: cortisol overproduction has a severe protein catabolic effect at skin with collagen network disruption while immune effect of hypercortisolemia induces chronic skin infections and difficulties in wound healing. In females, consecutive androgens excess induces acne, hirsutism, and androgens-related alopecia. The classical phenotype includes: fragile skin or skin atrophy, red/purple striae, easy bruising, facial plethora. Skin changes represent the window to pituitary tumours for clinicians of different specialities, therefore contributing to final diagnosis of endocrinopathies.https://rmj.com.ro/articles/2020.1/RMJ_2020_1_Art-01.pdfdermatologyacromegalycushing’s diseasediabetes mellituscutaneous |
| spellingShingle | Florica Sandru Ana Valea Simona Elena Albu Mihai Cristian Dumitrascu Constantin Dumitrache Ana Maria Alexandra Stanescu Mara Carsote Functioning pituitary tumours: Hints from the skin Romanian Medical Journal dermatology acromegaly cushing’s disease diabetes mellitus cutaneous |
| title | Functioning pituitary tumours: Hints from the skin |
| title_full | Functioning pituitary tumours: Hints from the skin |
| title_fullStr | Functioning pituitary tumours: Hints from the skin |
| title_full_unstemmed | Functioning pituitary tumours: Hints from the skin |
| title_short | Functioning pituitary tumours: Hints from the skin |
| title_sort | functioning pituitary tumours hints from the skin |
| topic | dermatology acromegaly cushing’s disease diabetes mellitus cutaneous |
| url | https://rmj.com.ro/articles/2020.1/RMJ_2020_1_Art-01.pdf |
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