Potential occupational exposure of parents to endocrine disrupting chemicals, adverse birth outcomes, and the modification effects of multi-vitamins supplement and infant sex
Background: Maternal occupational exposure to endocrine disrupting chemicals (EDCs) may have adverse effect on birth outcomes. However, little is known about paternal EDCs exposure and the combined effect of parental exposure on birth outcomes. Objectives: To assess the effects of both maternal and...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-03-01
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| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651322001543 |
| _version_ | 1819349582379745280 |
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| author | Huanhuan Zhang Yanqiu Li Xiaoxin Zhang Weiyi Chen Qianhong Liang Changchang Li Luke D. Knibbs Cunrui Huang Qiong Wang |
| author_facet | Huanhuan Zhang Yanqiu Li Xiaoxin Zhang Weiyi Chen Qianhong Liang Changchang Li Luke D. Knibbs Cunrui Huang Qiong Wang |
| author_sort | Huanhuan Zhang |
| collection | DOAJ |
| description | Background: Maternal occupational exposure to endocrine disrupting chemicals (EDCs) may have adverse effect on birth outcomes. However, little is known about paternal EDCs exposure and the combined effect of parental exposure on birth outcomes. Objectives: To assess the effects of both maternal and paternal occupational EDCs exposure on adverse birth outcomes, and further explore if multi-vitamins supplement and infant sex modify the association. Methods: We conducted a prospective cohort study of 5421 mother-father-newborn groups in Guangzhou, China. A questionnaire informed by a job exposure matrix (JEM) was applied to collect parental occupational EDCs exposure based on the type of work performed. We used logistic regression to estimate association between parental EDCs exposure and birth outcomes (including preterm birth (PTB), low birth weight (LBW), birth defects and congenital heart defects (CHD)). Stratified analyses and Cochran Q tests were performed to assess the modifying effect of maternal multi-vitamins supplement use and infant sex. Results: Compared with mothers unexposed, we found that mothers those exposed to EDCs were associated with increased odds of birth defects (aOR=1.70, 95% confidence interval (CI): 1.10–2.62), especially for those exposed for > 1.5 years (aOR= 3.00, 95% CIs: 1.78–5.03), or those with directly occupational exposed to EDCs (aOR= 2.94, 95% CIs: 1.72–5.04). Maternal exposure for > 1.5 years and direct exposure increased the risk of CHD, with aORs of 2.47 (1.21–5.02) and 2.79 (1.37–5.69), respectively. Stronger adverse effects were also observed when mothers and fathers were both exposed to EDCs. Paternal occupational EDCs exposure and exposure ≤ 1.5 years was associated with increased odds of LBW, with aORs of 2.14 (1.63–2.79) and 1.54 (1.10–2.15), respectively. When stratified by multi-vitamins supplement and infant sex, we observed slightly stronger effects for maternal exposure on birth defects/CHD as well as paternal EDCs exposure on PTB and LBW, among those without multi-vitamins supplement and among male babies, although the modification effects were not significant. Conclusion: Maternal exposure to EDCs was associated with greater odds of birth defects and CHD, while paternal exposure was mainly associated with greater odds of LBW. These effects tend to be stronger among mothers without multi-vitamins supplement and among male babies. |
| first_indexed | 2024-12-24T19:02:49Z |
| format | Article |
| id | doaj.art-571f079a51eb4e23938b8f2423882f1e |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-12-24T19:02:49Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-571f079a51eb4e23938b8f2423882f1e2022-12-21T16:43:10ZengElsevierEcotoxicology and Environmental Safety0147-65132022-03-01233113314Potential occupational exposure of parents to endocrine disrupting chemicals, adverse birth outcomes, and the modification effects of multi-vitamins supplement and infant sexHuanhuan Zhang0Yanqiu Li1Xiaoxin Zhang2Weiyi Chen3Qianhong Liang4Changchang Li5Luke D. Knibbs6Cunrui Huang7Qiong Wang8School of Public Health, Sun Yat-sen University, Guangzhou, China; School of Public Health, Zhengzhou University, Zhengzhou, ChinaGuangzhou Panyu Maternal Child Health Hospital (Guangzhou Panyu District He Xian Memorial Hospital), Guangzhou, ChinaSchool of Public Health, Sun Yat-sen University, Guangzhou, ChinaGuangzhou Panyu Maternal Child Health Hospital (Guangzhou Panyu District He Xian Memorial Hospital), Guangzhou, ChinaGuangzhou Panyu Maternal Child Health Hospital (Guangzhou Panyu District He Xian Memorial Hospital), Guangzhou, ChinaDepartment of Sexually Transmitted Disease Prevention and Control, Dermatology Hospital of Southern Medical University, Guangzhou, China; Institute for Global Health and Sexually Transmitted Infections, Southern Medical University, Guangzhou, ChinaSchool of Public Health, The University of Sydney, NSW 2006, AustraliaSchool of Public Health, Sun Yat-sen University, Guangzhou, ChinaSchool of Public Health, Sun Yat-sen University, Guangzhou, China; Corresponding author.Background: Maternal occupational exposure to endocrine disrupting chemicals (EDCs) may have adverse effect on birth outcomes. However, little is known about paternal EDCs exposure and the combined effect of parental exposure on birth outcomes. Objectives: To assess the effects of both maternal and paternal occupational EDCs exposure on adverse birth outcomes, and further explore if multi-vitamins supplement and infant sex modify the association. Methods: We conducted a prospective cohort study of 5421 mother-father-newborn groups in Guangzhou, China. A questionnaire informed by a job exposure matrix (JEM) was applied to collect parental occupational EDCs exposure based on the type of work performed. We used logistic regression to estimate association between parental EDCs exposure and birth outcomes (including preterm birth (PTB), low birth weight (LBW), birth defects and congenital heart defects (CHD)). Stratified analyses and Cochran Q tests were performed to assess the modifying effect of maternal multi-vitamins supplement use and infant sex. Results: Compared with mothers unexposed, we found that mothers those exposed to EDCs were associated with increased odds of birth defects (aOR=1.70, 95% confidence interval (CI): 1.10–2.62), especially for those exposed for > 1.5 years (aOR= 3.00, 95% CIs: 1.78–5.03), or those with directly occupational exposed to EDCs (aOR= 2.94, 95% CIs: 1.72–5.04). Maternal exposure for > 1.5 years and direct exposure increased the risk of CHD, with aORs of 2.47 (1.21–5.02) and 2.79 (1.37–5.69), respectively. Stronger adverse effects were also observed when mothers and fathers were both exposed to EDCs. Paternal occupational EDCs exposure and exposure ≤ 1.5 years was associated with increased odds of LBW, with aORs of 2.14 (1.63–2.79) and 1.54 (1.10–2.15), respectively. When stratified by multi-vitamins supplement and infant sex, we observed slightly stronger effects for maternal exposure on birth defects/CHD as well as paternal EDCs exposure on PTB and LBW, among those without multi-vitamins supplement and among male babies, although the modification effects were not significant. Conclusion: Maternal exposure to EDCs was associated with greater odds of birth defects and CHD, while paternal exposure was mainly associated with greater odds of LBW. These effects tend to be stronger among mothers without multi-vitamins supplement and among male babies.http://www.sciencedirect.com/science/article/pii/S0147651322001543Birth outcomesEndocrine disrupting chemicalsMulti-vitaminsInfant sex |
| spellingShingle | Huanhuan Zhang Yanqiu Li Xiaoxin Zhang Weiyi Chen Qianhong Liang Changchang Li Luke D. Knibbs Cunrui Huang Qiong Wang Potential occupational exposure of parents to endocrine disrupting chemicals, adverse birth outcomes, and the modification effects of multi-vitamins supplement and infant sex Ecotoxicology and Environmental Safety Birth outcomes Endocrine disrupting chemicals Multi-vitamins Infant sex |
| title | Potential occupational exposure of parents to endocrine disrupting chemicals, adverse birth outcomes, and the modification effects of multi-vitamins supplement and infant sex |
| title_full | Potential occupational exposure of parents to endocrine disrupting chemicals, adverse birth outcomes, and the modification effects of multi-vitamins supplement and infant sex |
| title_fullStr | Potential occupational exposure of parents to endocrine disrupting chemicals, adverse birth outcomes, and the modification effects of multi-vitamins supplement and infant sex |
| title_full_unstemmed | Potential occupational exposure of parents to endocrine disrupting chemicals, adverse birth outcomes, and the modification effects of multi-vitamins supplement and infant sex |
| title_short | Potential occupational exposure of parents to endocrine disrupting chemicals, adverse birth outcomes, and the modification effects of multi-vitamins supplement and infant sex |
| title_sort | potential occupational exposure of parents to endocrine disrupting chemicals adverse birth outcomes and the modification effects of multi vitamins supplement and infant sex |
| topic | Birth outcomes Endocrine disrupting chemicals Multi-vitamins Infant sex |
| url | http://www.sciencedirect.com/science/article/pii/S0147651322001543 |
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