Transmission traits of malaria parasites within the mosquito: Genetic variation, phenotypic plasticity, and consequences for control
Abstract Evaluating the risk of emergence and transmission of vector‐borne diseases requires knowledge of the genetic and environmental contributions to pathogen transmission traits. Compared to the significant effort devoted to understanding the biology of malaria transmission from vertebrate hosts...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-04-01
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| Series: | Evolutionary Applications |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/eva.12571 |
| _version_ | 1818342457124847616 |
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| author | Thierry Lefevre Johanna Ohm Kounbobr R. Dabiré Anna Cohuet Marc Choisy Matthew B. Thomas Lauren Cator |
| author_facet | Thierry Lefevre Johanna Ohm Kounbobr R. Dabiré Anna Cohuet Marc Choisy Matthew B. Thomas Lauren Cator |
| author_sort | Thierry Lefevre |
| collection | DOAJ |
| description | Abstract Evaluating the risk of emergence and transmission of vector‐borne diseases requires knowledge of the genetic and environmental contributions to pathogen transmission traits. Compared to the significant effort devoted to understanding the biology of malaria transmission from vertebrate hosts to mosquito vectors, the strategies that malaria parasites have evolved to maximize transmission from vectors to vertebrate hosts have been largely overlooked. While determinants of infection success within the mosquito host have recently received attention, the causes of variability for other key transmission traits of malaria, namely the duration of parasite development and its virulence within the vector, as well as its ability to alter mosquito behavior, remain largely unknown. This important gap in our knowledge needs to be bridged in order to obtain an integrative view of the ecology and evolution of malaria transmission strategies. Associations between transmission traits also need to be characterized, as they trade‐offs and constraints could have important implications for understanding the evolution of parasite transmission. Finally, theoretical studies are required to evaluate how genetic and environmental influences on parasite transmission traits can shape malaria dynamics and evolution in response to disease control. |
| first_indexed | 2024-12-13T16:14:59Z |
| format | Article |
| id | doaj.art-57220bf53e674b518961493e7f0425ce |
| institution | Directory Open Access Journal |
| issn | 1752-4571 |
| language | English |
| last_indexed | 2024-12-13T16:14:59Z |
| publishDate | 2018-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Evolutionary Applications |
| spelling | doaj.art-57220bf53e674b518961493e7f0425ce2022-12-21T23:38:51ZengWileyEvolutionary Applications1752-45712018-04-0111445646910.1111/eva.12571Transmission traits of malaria parasites within the mosquito: Genetic variation, phenotypic plasticity, and consequences for controlThierry Lefevre0Johanna Ohm1Kounbobr R. Dabiré2Anna Cohuet3Marc Choisy4Matthew B. Thomas5Lauren Cator6MIVEGEC, IRD, CNRS University of Montpellier Montpellier FranceDepartment of Entomology and Center for Infectious Disease Dynamics Penn State University University Park PA USAInstitut de Recherche en Sciences de la Santé (IRSS) Bobo Dioulasso Burkina FasoMIVEGEC, IRD, CNRS University of Montpellier Montpellier FranceMIVEGEC, IRD, CNRS University of Montpellier Montpellier FranceDepartment of Entomology and Center for Infectious Disease Dynamics Penn State University University Park PA USAGrand Challenges in Ecosystems and Environment Imperial College London Ascot UKAbstract Evaluating the risk of emergence and transmission of vector‐borne diseases requires knowledge of the genetic and environmental contributions to pathogen transmission traits. Compared to the significant effort devoted to understanding the biology of malaria transmission from vertebrate hosts to mosquito vectors, the strategies that malaria parasites have evolved to maximize transmission from vectors to vertebrate hosts have been largely overlooked. While determinants of infection success within the mosquito host have recently received attention, the causes of variability for other key transmission traits of malaria, namely the duration of parasite development and its virulence within the vector, as well as its ability to alter mosquito behavior, remain largely unknown. This important gap in our knowledge needs to be bridged in order to obtain an integrative view of the ecology and evolution of malaria transmission strategies. Associations between transmission traits also need to be characterized, as they trade‐offs and constraints could have important implications for understanding the evolution of parasite transmission. Finally, theoretical studies are required to evaluate how genetic and environmental influences on parasite transmission traits can shape malaria dynamics and evolution in response to disease control.https://doi.org/10.1111/eva.12571host–parasite interactionsmalariamosquitotransmission |
| spellingShingle | Thierry Lefevre Johanna Ohm Kounbobr R. Dabiré Anna Cohuet Marc Choisy Matthew B. Thomas Lauren Cator Transmission traits of malaria parasites within the mosquito: Genetic variation, phenotypic plasticity, and consequences for control Evolutionary Applications host–parasite interactions malaria mosquito transmission |
| title | Transmission traits of malaria parasites within the mosquito: Genetic variation, phenotypic plasticity, and consequences for control |
| title_full | Transmission traits of malaria parasites within the mosquito: Genetic variation, phenotypic plasticity, and consequences for control |
| title_fullStr | Transmission traits of malaria parasites within the mosquito: Genetic variation, phenotypic plasticity, and consequences for control |
| title_full_unstemmed | Transmission traits of malaria parasites within the mosquito: Genetic variation, phenotypic plasticity, and consequences for control |
| title_short | Transmission traits of malaria parasites within the mosquito: Genetic variation, phenotypic plasticity, and consequences for control |
| title_sort | transmission traits of malaria parasites within the mosquito genetic variation phenotypic plasticity and consequences for control |
| topic | host–parasite interactions malaria mosquito transmission |
| url | https://doi.org/10.1111/eva.12571 |
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