Non-synaptic signaling from cerebellar climbing fibers modulates Golgi cell activity
Golgi cells are the principal inhibitory neurons at the input stage of the cerebellum, providing feedforward and feedback inhibition through mossy fiber and parallel fiber synapses. In vivo studies have shown that Golgi cell activity is regulated by climbing fiber stimulation, yet there is little fu...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2017-10-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/29215 |
| _version_ | 1818019822488780800 |
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| author | Angela K Nietz Jada H Vaden Luke T Coddington Linda Overstreet-Wadiche Jacques I Wadiche |
| author_facet | Angela K Nietz Jada H Vaden Luke T Coddington Linda Overstreet-Wadiche Jacques I Wadiche |
| author_sort | Angela K Nietz |
| collection | DOAJ |
| description | Golgi cells are the principal inhibitory neurons at the input stage of the cerebellum, providing feedforward and feedback inhibition through mossy fiber and parallel fiber synapses. In vivo studies have shown that Golgi cell activity is regulated by climbing fiber stimulation, yet there is little functional or anatomical evidence for synapses between climbing fibers and Golgi cells. Here, we show that glutamate released from climbing fibers activates ionotropic and metabotropic receptors on Golgi cells through spillover-mediated transmission. The interplay of excitatory and inhibitory conductances provides flexible control over Golgi cell spiking, allowing either excitation or a biphasic sequence of excitation and inhibition following single climbing fiber stimulation. Together with prior studies of spillover transmission to molecular layer interneurons, these results reveal that climbing fibers exert control over inhibition at both the input and output layers of the cerebellar cortex. |
| first_indexed | 2024-04-14T07:56:40Z |
| format | Article |
| id | doaj.art-5723d950e29949cbb4d7f6843b83a5b4 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-14T07:56:40Z |
| publishDate | 2017-10-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-5723d950e29949cbb4d7f6843b83a5b42022-12-22T02:05:01ZengeLife Sciences Publications LtdeLife2050-084X2017-10-01610.7554/eLife.29215Non-synaptic signaling from cerebellar climbing fibers modulates Golgi cell activityAngela K Nietz0Jada H Vaden1Luke T Coddington2Linda Overstreet-Wadiche3https://orcid.org/0000-0001-7367-5998Jacques I Wadiche4https://orcid.org/0000-0001-8180-2061Department of Neurobiology, University of Alabama at Birmingham, Birmingham, United StatesDepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, United StatesDepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, United StatesDepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, United StatesDepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, United StatesGolgi cells are the principal inhibitory neurons at the input stage of the cerebellum, providing feedforward and feedback inhibition through mossy fiber and parallel fiber synapses. In vivo studies have shown that Golgi cell activity is regulated by climbing fiber stimulation, yet there is little functional or anatomical evidence for synapses between climbing fibers and Golgi cells. Here, we show that glutamate released from climbing fibers activates ionotropic and metabotropic receptors on Golgi cells through spillover-mediated transmission. The interplay of excitatory and inhibitory conductances provides flexible control over Golgi cell spiking, allowing either excitation or a biphasic sequence of excitation and inhibition following single climbing fiber stimulation. Together with prior studies of spillover transmission to molecular layer interneurons, these results reveal that climbing fibers exert control over inhibition at both the input and output layers of the cerebellar cortex.https://elifesciences.org/articles/29215spillovercerebellumGolgi cell |
| spellingShingle | Angela K Nietz Jada H Vaden Luke T Coddington Linda Overstreet-Wadiche Jacques I Wadiche Non-synaptic signaling from cerebellar climbing fibers modulates Golgi cell activity eLife spillover cerebellum Golgi cell |
| title | Non-synaptic signaling from cerebellar climbing fibers modulates Golgi cell activity |
| title_full | Non-synaptic signaling from cerebellar climbing fibers modulates Golgi cell activity |
| title_fullStr | Non-synaptic signaling from cerebellar climbing fibers modulates Golgi cell activity |
| title_full_unstemmed | Non-synaptic signaling from cerebellar climbing fibers modulates Golgi cell activity |
| title_short | Non-synaptic signaling from cerebellar climbing fibers modulates Golgi cell activity |
| title_sort | non synaptic signaling from cerebellar climbing fibers modulates golgi cell activity |
| topic | spillover cerebellum Golgi cell |
| url | https://elifesciences.org/articles/29215 |
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