Layer 6 ensembles can selectively regulate the behavioral impact and layer-specific representation of sensory deviants
Predictive models can enhance the salience of unanticipated input. Here, we tested a key potential node in neocortical model formation in this process, layer (L) 6, using behavioral, electrophysiological and imaging methods in mouse primary somatosensory neocortex. We found that deviant stimuli enha...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2020-12-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/48957 |
| _version_ | 1818019548315516928 |
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| author | Jakob Voigts Christopher A Deister Christopher I Moore |
| author_facet | Jakob Voigts Christopher A Deister Christopher I Moore |
| author_sort | Jakob Voigts |
| collection | DOAJ |
| description | Predictive models can enhance the salience of unanticipated input. Here, we tested a key potential node in neocortical model formation in this process, layer (L) 6, using behavioral, electrophysiological and imaging methods in mouse primary somatosensory neocortex. We found that deviant stimuli enhanced tactile detection and were encoded in L2/3 neural tuning. To test the contribution of L6, we applied weak optogenetic drive that changed which L6 neurons were sensory responsive, without affecting overall firing rates in L6 or L2/3. This stimulation selectively suppressed behavioral sensitivity to deviant stimuli, without impacting baseline performance. This stimulation also eliminated deviance encoding in L2/3 but did not impair basic stimulus responses across layers. In contrast, stronger L6 drive inhibited firing and suppressed overall sensory function. These findings indicate that, despite their sparse activity, specific ensembles of stimulus-driven L6 neurons are required to form neocortical predictions, and to realize their behavioral benefit. |
| first_indexed | 2024-04-14T07:52:39Z |
| format | Article |
| id | doaj.art-5725441af90349b4b204af8a1c988c10 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-14T07:52:39Z |
| publishDate | 2020-12-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-5725441af90349b4b204af8a1c988c102022-12-22T02:05:08ZengeLife Sciences Publications LtdeLife2050-084X2020-12-01910.7554/eLife.48957Layer 6 ensembles can selectively regulate the behavioral impact and layer-specific representation of sensory deviantsJakob Voigts0https://orcid.org/0000-0002-5174-7214Christopher A Deister1https://orcid.org/0000-0002-9579-918XChristopher I Moore2https://orcid.org/0000-0003-4534-1602Department of Neuroscience and Carney Institute for Brain Science, Brown University, Providence, United States; Department of Brain and Cognitive Sciences, MIT, Cambridge, United StatesDepartment of Neuroscience and Carney Institute for Brain Science, Brown University, Providence, United StatesDepartment of Neuroscience and Carney Institute for Brain Science, Brown University, Providence, United StatesPredictive models can enhance the salience of unanticipated input. Here, we tested a key potential node in neocortical model formation in this process, layer (L) 6, using behavioral, electrophysiological and imaging methods in mouse primary somatosensory neocortex. We found that deviant stimuli enhanced tactile detection and were encoded in L2/3 neural tuning. To test the contribution of L6, we applied weak optogenetic drive that changed which L6 neurons were sensory responsive, without affecting overall firing rates in L6 or L2/3. This stimulation selectively suppressed behavioral sensitivity to deviant stimuli, without impacting baseline performance. This stimulation also eliminated deviance encoding in L2/3 but did not impair basic stimulus responses across layers. In contrast, stronger L6 drive inhibited firing and suppressed overall sensory function. These findings indicate that, despite their sparse activity, specific ensembles of stimulus-driven L6 neurons are required to form neocortical predictions, and to realize their behavioral benefit.https://elifesciences.org/articles/48957cortexoddballdeviantvibrissapredictionlayer 6 |
| spellingShingle | Jakob Voigts Christopher A Deister Christopher I Moore Layer 6 ensembles can selectively regulate the behavioral impact and layer-specific representation of sensory deviants eLife cortex oddball deviant vibrissa prediction layer 6 |
| title | Layer 6 ensembles can selectively regulate the behavioral impact and layer-specific representation of sensory deviants |
| title_full | Layer 6 ensembles can selectively regulate the behavioral impact and layer-specific representation of sensory deviants |
| title_fullStr | Layer 6 ensembles can selectively regulate the behavioral impact and layer-specific representation of sensory deviants |
| title_full_unstemmed | Layer 6 ensembles can selectively regulate the behavioral impact and layer-specific representation of sensory deviants |
| title_short | Layer 6 ensembles can selectively regulate the behavioral impact and layer-specific representation of sensory deviants |
| title_sort | layer 6 ensembles can selectively regulate the behavioral impact and layer specific representation of sensory deviants |
| topic | cortex oddball deviant vibrissa prediction layer 6 |
| url | https://elifesciences.org/articles/48957 |
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