Epigenetics and Neuroinflammation Associated With Neurodevelopmental Disorders: A Microglial Perspective
Neuroinflammation is a cause of neurodevelopmental disorders such as autism spectrum disorders, fetal alcohol syndrome, and cerebral palsy. Converging lines of evidence from basic and clinical sciences suggest that dysregulation of the epigenetic landscape, including DNA methylation and miRNA expres...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-05-01
|
| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.852752/full |
| _version_ | 1818554187220254720 |
|---|---|
| author | Munekazu Komada Yuhei Nishimura |
| author_facet | Munekazu Komada Yuhei Nishimura |
| author_sort | Munekazu Komada |
| collection | DOAJ |
| description | Neuroinflammation is a cause of neurodevelopmental disorders such as autism spectrum disorders, fetal alcohol syndrome, and cerebral palsy. Converging lines of evidence from basic and clinical sciences suggest that dysregulation of the epigenetic landscape, including DNA methylation and miRNA expression, is associated with neuroinflammation. Genetic and environmental factors can affect the interaction between epigenetics and neuroinflammation, which may cause neurodevelopmental disorders. In this minireview, we focus on neuroinflammation that might be mediated by epigenetic dysregulation in microglia, and compare studies using mammals and zebrafish. |
| first_indexed | 2024-12-12T09:36:03Z |
| format | Article |
| id | doaj.art-57264100bb68443aaf7fac981ac67645 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-12T09:36:03Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-57264100bb68443aaf7fac981ac676452022-12-22T00:28:43ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-05-011010.3389/fcell.2022.852752852752Epigenetics and Neuroinflammation Associated With Neurodevelopmental Disorders: A Microglial PerspectiveMunekazu Komada0Yuhei Nishimura1Mammalian Embryology, Department of Life Science, Faculty of Science and Engineering, Kindai University, Osaka, JapanDepartment of Integrative Pharmacology, Mie University Graduate School of Medicine, Tsu, JapanNeuroinflammation is a cause of neurodevelopmental disorders such as autism spectrum disorders, fetal alcohol syndrome, and cerebral palsy. Converging lines of evidence from basic and clinical sciences suggest that dysregulation of the epigenetic landscape, including DNA methylation and miRNA expression, is associated with neuroinflammation. Genetic and environmental factors can affect the interaction between epigenetics and neuroinflammation, which may cause neurodevelopmental disorders. In this minireview, we focus on neuroinflammation that might be mediated by epigenetic dysregulation in microglia, and compare studies using mammals and zebrafish.https://www.frontiersin.org/articles/10.3389/fcell.2022.852752/fullmicrogliamicroRNADNA methylationzebrafishrodentsfetal alcohol syndrome |
| spellingShingle | Munekazu Komada Yuhei Nishimura Epigenetics and Neuroinflammation Associated With Neurodevelopmental Disorders: A Microglial Perspective Frontiers in Cell and Developmental Biology microglia microRNA DNA methylation zebrafish rodents fetal alcohol syndrome |
| title | Epigenetics and Neuroinflammation Associated With Neurodevelopmental Disorders: A Microglial Perspective |
| title_full | Epigenetics and Neuroinflammation Associated With Neurodevelopmental Disorders: A Microglial Perspective |
| title_fullStr | Epigenetics and Neuroinflammation Associated With Neurodevelopmental Disorders: A Microglial Perspective |
| title_full_unstemmed | Epigenetics and Neuroinflammation Associated With Neurodevelopmental Disorders: A Microglial Perspective |
| title_short | Epigenetics and Neuroinflammation Associated With Neurodevelopmental Disorders: A Microglial Perspective |
| title_sort | epigenetics and neuroinflammation associated with neurodevelopmental disorders a microglial perspective |
| topic | microglia microRNA DNA methylation zebrafish rodents fetal alcohol syndrome |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.852752/full |
| work_keys_str_mv | AT munekazukomada epigeneticsandneuroinflammationassociatedwithneurodevelopmentaldisordersamicroglialperspective AT yuheinishimura epigeneticsandneuroinflammationassociatedwithneurodevelopmentaldisordersamicroglialperspective |