Long Non-coding RNA Signature for Liver Metastasis of Colorectal Cancers
Colorectal cancer ranks within the top three cancers both in terms of incidence as well as deaths. Metastasis is often the major cause of mortality and liver is the primary and most common site to which colorectal cancers metastasize. We tested the prognostic ability of a long non-coding RNA (lncRNA...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.707115/full |
| _version_ | 1819204305125638144 |
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| author | Fang Liu Zhen-Mei Song Xiao-Di Wang Shi-Yu Du Na Peng Jing-Rui Zhou Ming-Gang Zhang |
| author_facet | Fang Liu Zhen-Mei Song Xiao-Di Wang Shi-Yu Du Na Peng Jing-Rui Zhou Ming-Gang Zhang |
| author_sort | Fang Liu |
| collection | DOAJ |
| description | Colorectal cancer ranks within the top three cancers both in terms of incidence as well as deaths. Metastasis is often the major cause of mortality and liver is the primary and most common site to which colorectal cancers metastasize. We tested the prognostic ability of a long non-coding RNA (lncRNA) signature in liver metastatic colorectal cancers. We first evaluated expression levels of several lncRNAs in eight excised liver metastases from primary colorectal cancers and found significantly upregulated lncRNAs HOTAIR and MALAT1 along with significantly downregulated LOC285194. We further compared the expression levels of HOTAIR, MALAT1 and LOC285194 in primary colorectal tumors at the time of initial diagnosis and correlated them with disease progression and liver metastasis. HOTAIR and MALAT1 were significantly upregulated and LOC285194 was significantly downregulated in twelve patients who were diagnosed with liver metastasis within 5 years of initial diagnosis, compared to the five patients with no metastasis. A positive signature comprising of high HOTAIR/MALAT1 and low LOC285194 also correlated with progression to higher grade tumors. Thus, the lncRNA signature comprising of high HOTAIR/MALAT1 and low LOC285194 could be a prognostic signature for liver metastasis as well as overall poor survival. |
| first_indexed | 2024-12-23T04:33:42Z |
| format | Article |
| id | doaj.art-57299c2ccdc14c809342a8c07c3c1dab |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-23T04:33:42Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-57299c2ccdc14c809342a8c07c3c1dab2022-12-21T17:59:57ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-07-01910.3389/fcell.2021.707115707115Long Non-coding RNA Signature for Liver Metastasis of Colorectal CancersFang Liu0Zhen-Mei Song1Xiao-Di Wang2Shi-Yu Du3Na Peng4Jing-Rui Zhou5Ming-Gang Zhang6Department of Gastroenterology, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Gastroenterology, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Gastroenterology, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Gastroenterology, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Gastroenterology, China-Japan Friendship Hospital, Beijing, ChinaDepartment of Gastroenterology, Shan GU Hospital, Handan, ChinaDepartment of Gastroenterology, China-Japan Friendship Hospital, Beijing, ChinaColorectal cancer ranks within the top three cancers both in terms of incidence as well as deaths. Metastasis is often the major cause of mortality and liver is the primary and most common site to which colorectal cancers metastasize. We tested the prognostic ability of a long non-coding RNA (lncRNA) signature in liver metastatic colorectal cancers. We first evaluated expression levels of several lncRNAs in eight excised liver metastases from primary colorectal cancers and found significantly upregulated lncRNAs HOTAIR and MALAT1 along with significantly downregulated LOC285194. We further compared the expression levels of HOTAIR, MALAT1 and LOC285194 in primary colorectal tumors at the time of initial diagnosis and correlated them with disease progression and liver metastasis. HOTAIR and MALAT1 were significantly upregulated and LOC285194 was significantly downregulated in twelve patients who were diagnosed with liver metastasis within 5 years of initial diagnosis, compared to the five patients with no metastasis. A positive signature comprising of high HOTAIR/MALAT1 and low LOC285194 also correlated with progression to higher grade tumors. Thus, the lncRNA signature comprising of high HOTAIR/MALAT1 and low LOC285194 could be a prognostic signature for liver metastasis as well as overall poor survival.https://www.frontiersin.org/articles/10.3389/fcell.2021.707115/fullcolorectal cancerliver metastasisHOTAIRMALAT1LOC285194 |
| spellingShingle | Fang Liu Zhen-Mei Song Xiao-Di Wang Shi-Yu Du Na Peng Jing-Rui Zhou Ming-Gang Zhang Long Non-coding RNA Signature for Liver Metastasis of Colorectal Cancers Frontiers in Cell and Developmental Biology colorectal cancer liver metastasis HOTAIR MALAT1 LOC285194 |
| title | Long Non-coding RNA Signature for Liver Metastasis of Colorectal Cancers |
| title_full | Long Non-coding RNA Signature for Liver Metastasis of Colorectal Cancers |
| title_fullStr | Long Non-coding RNA Signature for Liver Metastasis of Colorectal Cancers |
| title_full_unstemmed | Long Non-coding RNA Signature for Liver Metastasis of Colorectal Cancers |
| title_short | Long Non-coding RNA Signature for Liver Metastasis of Colorectal Cancers |
| title_sort | long non coding rna signature for liver metastasis of colorectal cancers |
| topic | colorectal cancer liver metastasis HOTAIR MALAT1 LOC285194 |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.707115/full |
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