Morusin Enhances Temozolomide Efficiency in GBM by Inducing Cytoplasmic Vacuolization and Endoplasmic Reticulum Stress

Morusin Enhances Temozolomide Efficiency in GBM by Inducing Cytoplasmic Vacuolization and Endoplasmic Reticulum Stress

Glioblastoma multiforme (GBM) is an aggressive brain tumor with high risks of recurrence and mortality. Chemoradiotherapy resistance has been considered a major factor contributing to the extremely poor prognosis of GBM patients. Therefore, there is an urgent need to develop highly effective therape...

Full description

Bibliographic Details
Main Authors:	Rongchuan Zhao, Yuanshuai Zhou, Hong Zhang, Jinlin Pan, Fan Yang, Ruobing Zhang, Nafees Ahmad, Jiao Yang, Minxuan Sun
Format:	Article
Language:	English
Published:	MDPI AG 2022-06-01
Series:	Journal of Clinical Medicine
Subjects:	glioblastoma multiforme morusin cytoplasmic vacuolation endoplasmic reticulum stress tumor progression
Online Access:	https://www.mdpi.com/2077-0383/11/13/3662

Similar Items

Endoplasmic Reticulum Stress Mediates Renal Tubular Vacuolation in BK Polyomavirus-Associated Nephropathy
by: Guo-Dong Zhao, et al.
Published: (2022-04-01)

The Pro-Health Benefits of Morusin Administration—An Update Review
by: Anita Panek-Krzyśko, et al.
Published: (2021-08-01)

Morusin Suppresses Cancer Cell Invasion and MMP-2 Expression through ERK Signaling in Human Nasopharyngeal Carcinoma
by: Cheng-Chen Huang, et al.
Published: (2020-10-01)

Renal oncocytoma with vacuolated cells and giant mitochondria: Report of a rare tumor and review of the literature
by: Ashmi Patel, et al.
Published: (2023-09-01)

Cannabinoid Combination Induces Cytoplasmic Vacuolation in MCF-7 Breast Cancer Cells
by: Recardia Schoeman, et al.
Published: (2020-10-01)

Morusin shows potent antitumor activity for melanoma through apoptosis induction and proliferation inhibition
by: Wei Liu, et al.
Published: (2023-06-01)

Antitumor Effect of Morusin via G1 Arrest and Antiglycolysis by AMPK Activation in Hepatocellular Cancer
by: Ah-Reum Cho, et al.
Published: (2021-09-01)

Exploring the therapeutic and anti-tumor properties of morusin: a review of recent advances
by: Amna Hafeez, et al.
Published: (2023-05-01)

Prenylated phenolics as promising candidates for combination antibacterial therapy: Morusin and kuwanon G
by: Petruta Aelenei, et al.
Published: (2020-10-01)

Biomarker identification of isolated compartments of the cell wall, cytoplasm and vacuole from the internodal cell of characean Nitellopsis obtusa
by: Brigita Gylytė, et al.
Published: (2021-02-01)

Morusin induces osteogenic differentiation of bone marrow mesenchymal stem cells by canonical Wnt/β-catenin pathway and prevents bone loss in an ovariectomized rat model
by: Ming Chen, et al.
Published: (2021-03-01)

Anti-Allergic and Anti-Inflammatory Effects of Kuwanon G and Morusin on MC/9 Mast Cells and HaCaT Keratinocytes
by: Seong Eun Jin, et al.
Published: (2019-01-01)

Stress Granule Formation Attenuates RACK1-Mediated Apoptotic Cell Death Induced by Morusin
by: Ye-Jin Park, et al.
Published: (2020-07-01)

The Beneficial Effects of Morusin, an Isoprene Flavonoid Isolated from the Root Bark of <i>Morus</i>
by: Dong Wook Choi, et al.
Published: (2020-09-01)

3D correlative electron microscopy reveals continuity of Brucella-containing vacuoles with the endoplasmic reticulum
by: Sedzicki, Jaroslaw, et al.
Published: (2018)

Morusin shows potent antitumor activity for human hepatocellular carcinoma in vitro and in vivo through apoptosis induction and angiogenesis inhibition
by: Gao L, et al.
Published: (2017-06-01)

Morusin Ameliorates IL-1β-Induced Chondrocyte Inflammation and Osteoarthritis via NF-κB Signal Pathway
by: Jia Y, et al.
Published: (2020-03-01)

Morusin Functions as a Lipogenesis Inhibitor as Well as a Lipolysis Stimulator in Differentiated 3T3-L1 and Primary Adipocytes
by: Mi Rim Lee, et al.
Published: (2018-08-01)

Gold nanoparticles administration induces disarray of heart muscle, hemorrhagic, chronic inflammatory cells infiltrated by small lymphocytes, cytoplasmic vacuolization and congested and dilated blood vessels
by: Abdelhalim Mohamed Anwar K
Published: (2011-12-01)

Characteristics of weak base-induced vacuoles formed around individual acidic organelles
by: Tadashi Kawakami, et al.
Published: (2011-07-01)

Rutin Linoleate Triggers Oxidative Stress-Mediated Cytoplasmic Vacuolation in Non-Small Cell Lung Cancer Cells
by: Iasmina Marcovici, et al.
Published: (2024-02-01)

Promotion of cytoplasmic vacuolation-mediated cell death of human prostate cancer PC-3 cells by oxidative stress induced by daucusol, a new guaiane-type sesquiterpenoid from Daucus carota L.
by: Han Haote, et al.
Published: (2017-01-01)

A Review of Plant Vacuoles: Formation, Located Proteins, and Functions
by: Xiaona Tan, et al.
Published: (2019-09-01)

Morusin Protected Ruminal Epithelial Cells against Lipopolysaccharide-Induced Inflammation through Inhibiting EGFR-AKT/NF-κB Signaling and Improving Barrier Functions
by: Chunlei Yang, et al.
Published: (2022-11-01)

Characterization of metabolism feature and potential pharmacological changes of morusin-a promising anti-tumor drug-by ultra-high-performance liquid chromatography coupled time-of-flight mass spectrometry and network pharmacology
by: Feng-xiang Zhang, et al.
Published: (2021-02-01)

miR193a-5p Mediated ZNF746 and c-Myc Signaling Axis Is Critically Involved in Morusin Induced Apoptosis in Colorectal Cancer Cells
by: Woon-Yi Park, et al.
Published: (2021-08-01)

The Parasitic Intracellular Lifestyle of Trypanosomatids: Parasitophorous Vacuole Development and Survival
by: Marina Ferreira Batista, et al.
Published: (2020-06-01)

Methuosis Contributes to Jaspine-B-Induced Cell Death
by: Núria Bielsa, et al.
Published: (2022-06-01)

The Digestive Vacuole of the Malaria Parasite: A Specialized Lysosome
by: Mark F. Wiser
Published: (2024-02-01)

Cytological Applications of the Vacuolization Phenomenon as a Means of Determining Saline Cytotoxicity
by: Onisan Emilian, et al.
Published: (2023-07-01)

Multiscale imaging reveals the presence of autophagic vacuoles in developing maize endosperm
by: Elsa Arcalís, et al.
Published: (2023-01-01)

Cyclometalated Iridium(III) Complex–Cationic Peptide Hybrids Trigger Paraptosis in Cancer Cells via an Intracellular Ca<sup>2+</sup> Overload from the Endoplasmic Reticulum and a Decrease in Mitochondrial Membrane Potential
by: Chandrasekar Balachandran, et al.
Published: (2021-11-01)

Cryopreservation enhances vacuolization in human spermatozoa
by: Nahid Yari, et al.
Published: (2017-01-01)

At the Nexus between Cytoskeleton and Vacuole: How Plant Cytoskeletons Govern the Dynamics of Large Vacuoles
by: Hirotomo Takatsuka, et al.
Published: (2023-02-01)

Substrate ubiquitination retains misfolded membrane proteins in the endoplasmic reticulum for degradation
by: Zhihao Sun, et al.
Published: (2021-09-01)

Cytopenia associated with copper deficiency
by: Kaori Uchino, et al.
Published: (2021-11-01)

Ultrastructure of intracytoplasmic Rickettsia-like infection of the gills of the teleost Archosargus probatocephalus (Sparidae) in northeastern Brazil
by: Themis Jesus Silva, et al.
Published: (2020-09-01)

Specular Microscopic Features of Corneal Endothelial Vacuolation
by: Mozhgan Rezaei Kanavi, et al.
Published: (2011-01-01)

Protective Effects of Morus Root Extract (MRE) Against Lipopolysaccharide-Activated RAW264.7 Cells and CCl4-Induced Mouse Hepatic Damage
by: Tsui-Hwa Tseng, et al.
Published: (2018-11-01)

Chloroplast Degradation: Multiple Routes Into the Vacuole
by: Xiaohong Zhuang, et al.
Published: (2019-03-01)