Safety of prophylactic intracameral moxifloxacin ophthalmic solution after cataract surgery in patients with penetrating keratoplasty
<b>AIM:</b>To determine the safety of prophylactic intracameral moxifloxacin after cataract surgery in patients with penetrating keratoplasty (PKP).<b>METHODS:</b>In this retrospective study of consecutive patients who had phacoemulsification cataract surgery after PKP, were...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2014-10-01
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| Series: | International Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.cn/en_publish/2014/5/20140510.pdf |
| _version_ | 1818549709118111744 |
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| author | Osman Sevki Arslan Ceyhun Arici Mustafa Unal Erdogan Cicik Mehmet Serhat Mangan Eray Atalay |
| author_facet | Osman Sevki Arslan Ceyhun Arici Mustafa Unal Erdogan Cicik Mehmet Serhat Mangan Eray Atalay |
| author_sort | Osman Sevki Arslan |
| collection | DOAJ |
| description | <b>AIM:</b>To determine the safety of prophylactic intracameral moxifloxacin after cataract surgery in patients with penetrating keratoplasty (PKP).<b>METHODS:</b>In this retrospective study of consecutive patients who had phacoemulsification cataract surgery after PKP, were treated with intracameral moxifloxacin 0.5% ophthalmic solution (0.5 mg/0.1 mL). The main outcome measures were anterior chamber reaction, best corrected visual acuity (BCVA), corneal endothelial cell count (ECC), and central corneal thickness (CCT).<b>RESULTS:</b>Fifty-five patients were recruited (26 males, 29 females). The mean age was 54.36±4.97y (range 45-64y). All eyes had improved postoperative BCVA. The mean BCVA was 0.25 preoperatively and 0.57 postoperatively, which was statistically significant (<i>P<</i>0.001). One eye had 3+, 7 eyes had 2+, 12 eyes had 1+ and 8 eyes had trace amount of aqueous cells on the first day after surgery. All eyes had no anterior chamber cells at subsequent follow up examinations. Effective phacoemulsification time was 4.33±1.01s. The mean ECC was 2340.20 cells/mm<sup>2</sup> preoperatively and 1948.75 cells/mm<sup>2</sup> 1mo postoperatively (<i>P<</i>0.001). The increase of 21.09 µm in postoperative pachymetry 1mo after surgery was statistically significant (<i>P<</i>0.001).<b>CONCLUSION:</b> No untoward effects were observed after intracameral injection of moxifloxacin (0.5 mg/0.1 mL) in terms of anterior chamber reaction, CCT, ECC, and visual rehabilitation at the conclusion of cataract surgery in patients with PKP. |
| first_indexed | 2024-12-12T08:36:53Z |
| format | Article |
| id | doaj.art-572cb8e269fa404c83074e62c7316f05 |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-12-12T08:36:53Z |
| publishDate | 2014-10-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-572cb8e269fa404c83074e62c7316f052022-12-22T00:30:54ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982014-10-017579579910.3980/j.issn.2222-3959.2014.05.10Safety of prophylactic intracameral moxifloxacin ophthalmic solution after cataract surgery in patients with penetrating keratoplastyOsman Sevki Arslan0Ceyhun Arici1Mustafa Unal2Erdogan Cicik3Mehmet Serhat Mangan4Eray Atalay5Department of Ophthalmology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul 34098, TurkeyDepartment of Ophthalmology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul 34098, TurkeyDepartment of Ophthalmology, Medical Faculty, Akdeniz University, Antalya 07070, TurkeyDepartment of Ophthalmology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul 34098, TurkeyDepartment of Ophthalmology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul 34098, TurkeyDepartment of Ophthalmology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul 34098, Turkey<b>AIM:</b>To determine the safety of prophylactic intracameral moxifloxacin after cataract surgery in patients with penetrating keratoplasty (PKP).<b>METHODS:</b>In this retrospective study of consecutive patients who had phacoemulsification cataract surgery after PKP, were treated with intracameral moxifloxacin 0.5% ophthalmic solution (0.5 mg/0.1 mL). The main outcome measures were anterior chamber reaction, best corrected visual acuity (BCVA), corneal endothelial cell count (ECC), and central corneal thickness (CCT).<b>RESULTS:</b>Fifty-five patients were recruited (26 males, 29 females). The mean age was 54.36±4.97y (range 45-64y). All eyes had improved postoperative BCVA. The mean BCVA was 0.25 preoperatively and 0.57 postoperatively, which was statistically significant (<i>P<</i>0.001). One eye had 3+, 7 eyes had 2+, 12 eyes had 1+ and 8 eyes had trace amount of aqueous cells on the first day after surgery. All eyes had no anterior chamber cells at subsequent follow up examinations. Effective phacoemulsification time was 4.33±1.01s. The mean ECC was 2340.20 cells/mm<sup>2</sup> preoperatively and 1948.75 cells/mm<sup>2</sup> 1mo postoperatively (<i>P<</i>0.001). The increase of 21.09 µm in postoperative pachymetry 1mo after surgery was statistically significant (<i>P<</i>0.001).<b>CONCLUSION:</b> No untoward effects were observed after intracameral injection of moxifloxacin (0.5 mg/0.1 mL) in terms of anterior chamber reaction, CCT, ECC, and visual rehabilitation at the conclusion of cataract surgery in patients with PKP.http://www.ijo.cn/en_publish/2014/5/20140510.pdfcataract surgeryintracameral injectionmoxifloxacinpenetrating keratoplastyphacoemulsificationphacoemulsification |
| spellingShingle | Osman Sevki Arslan Ceyhun Arici Mustafa Unal Erdogan Cicik Mehmet Serhat Mangan Eray Atalay Safety of prophylactic intracameral moxifloxacin ophthalmic solution after cataract surgery in patients with penetrating keratoplasty International Journal of Ophthalmology cataract surgery intracameral injection moxifloxacin penetrating keratoplasty phacoemulsification phacoemulsification |
| title | Safety of prophylactic intracameral moxifloxacin ophthalmic solution after cataract surgery in patients with penetrating keratoplasty |
| title_full | Safety of prophylactic intracameral moxifloxacin ophthalmic solution after cataract surgery in patients with penetrating keratoplasty |
| title_fullStr | Safety of prophylactic intracameral moxifloxacin ophthalmic solution after cataract surgery in patients with penetrating keratoplasty |
| title_full_unstemmed | Safety of prophylactic intracameral moxifloxacin ophthalmic solution after cataract surgery in patients with penetrating keratoplasty |
| title_short | Safety of prophylactic intracameral moxifloxacin ophthalmic solution after cataract surgery in patients with penetrating keratoplasty |
| title_sort | safety of prophylactic intracameral moxifloxacin ophthalmic solution after cataract surgery in patients with penetrating keratoplasty |
| topic | cataract surgery intracameral injection moxifloxacin penetrating keratoplasty phacoemulsification phacoemulsification |
| url | http://www.ijo.cn/en_publish/2014/5/20140510.pdf |
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